Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges

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Reference

Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges

MONTENEGRO GARCIA, Javier, et al.

Abstract

Dynamic amphiphiles have a “bridge” between their charged head and their hydrophobic tails.

The presence of dynamic covalent bonds is of interest for differential and biosensing applications as well as for rapid access to the libraries needed to screen for gene delivery or cellular uptake of siRNA. However, efforts to develop libraries have so far concentrated on hydrazone bridges to monocationic heads. Here, we report synthesis efforts to enlarge this focused library with oxime and disulfide bridges and dynamic amphiphiles with more than one positive charge. Evaluation in fluorogenic vesicles reveals best activation of DNA as ion transporters by dynamic amphiphiles with dendritic scaffolds, doubly charged heads and four tails. Moreover, oximes, contrary to hydrazones, remain active under acidic conditions. Linear elongation of dendritic head-groups seems to cause increasing detergent effects and should therefore be avoided.

MONTENEGRO GARCIA, Javier, et al . Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges. Chemistry - A European Journal , 2012, vol. 18, no. 33, p. 10436-10443

DOI : 10.1002/chem.201200550

Available at:

http://archive-ouverte.unige.ch/unige:21981

Disclaimer: layout of this document may differ from the published version.

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