Article pp.435-437 du Vol.21 n°4 (2001)

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ANNEX

Opinion on the safety limits in the dietary consumption of vitamins and certain minerals

Conseil supérieur d’hygiène publique de France (CSHPF)

Section de l’alimentation et de la nutrition (French Council for Public Hygiene — Food and Nutrition Divi- sion)

Session of 12 September 1995

According to bibliographic reviews and reports presented to the Council on the basis of medical publications describing observation of side effects in man related to the consumption of the following vitamins and minerals,

According to food toxicology rules applied to the setting of an acceptable daily intake (ADI) where the side effect of food components in man is known,

According to the recommendations of French nutrition experts (DUPINet al., 1992) stating the quantities of vitamins and minerals which are advised to consume each day, defined as ANCs for the French population, in order to assure a good nutritional balance, knowing that these recommended levels of intake have been calculated very widely in order to prevent any deficiency risk in the population,

According to the recent studies carried out in France giving the range values for the actual intake of vitamins and minerals.

Opinion

The CSHPF (Food and Nutrition Division) is of the opinion that the safety limits for the daily consumption of vitamins and minerals have to be determined at the following levels for adults. The correspondence table of recommended dietary intakes (DUPINet al., 1992) (ANCs) allows the safety thresholds for any to be obtained by multiplying the ANCs by the corresponding factor. It does not vary with age.

Vitamins

Considering that the previously referenced publications delt with the conse- quences of supplementary vitamins, excluding vitamins provided by a varied diet, the following safety limits apply to these supplementary vitamins. Thus, the safety limits will apply to vitamin-enriched foods, food complements containing vitamins and other similar practices.

SCIENCES DES ALIMENTS, 21(2001) 435-437

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Vitamins Daily intake not to be exceeded ANCs (1) on top of the dietary intake correspondence Vitamin A (retinol) 1,000 µg or 3,300 IU ×1

Vitamin D 25 µg or 1,000 IU ×2,5

Vitamin E 40 mg or 60 IU ×4

Vitamin B₆ 5 mg ×2

Niacin (vitamin PP) 33 mg ×2

Folic acid 600 µg ×2

Vitamin C 1,000 mg ×12

(1) DUPINet al. 1992.

Scientific knowledge on the following vitamins, thiamin, riboflavin, biotin, pantothenic acid, and vitamin B₁₂, does not justify a safety threshold, as no verified observation of side effects after their ingestion has been experimentally controled.

Minerals

Considering that the publications on the side effects of minerals took into account minerals contained in foods, beverages and also supplements, the following safety limits apply to the totality of the consumption of minerals, whate- ver the form in which they are ingested (total intake).

Minerals Daily intake not to be exceeded ANCs (1) correspondence including that of a varied diet Total intake

Selenium 150 µg ×2

Zinc 15 mg ×1

Fluor 0.04 mg/kg ×2

(1) DUPINet al. 1992.

Other minerals have not yet been studied.

General comment

The CSHPF (Food and Nutrition Division) declares that the safety thresholds defined above do not in any case enhance the consumption of these vitamins and minerals. It recalls that nutritional balance is ensured by the intakes determined in the recommended ANCs (DUPINet al., 1992). These are the only intakes justified by nutritional needs and they are provided through a varied diet.

This advise states safety limits in the consumption of vitamins and minerals presenting a recognized risk level. It leads to establish an overall recommended maximum daily intake of vitamins and minerals. This advise does not determine a breakdown of this dose between the various foodstuffs or nutritional supplements. The intake level for each of the providing sources will be determined according to the applying rules.

436 Sci. Aliments 21(4), 2001 Nutritional Recommendations for the French Population

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This recommandation may be delevered as a full note, without any dele- tions or additions

Reference

Recommended Dietary Intakes for the French population (ANCs). DUPIN H.

ABRAHAM J., GIACHETTI I., 1 vol., Tec & Doc Lavoisier Paris éd., 2^eéd., 1992.

Opinion on the safety limits in the dietary consumption of vitamins and certain minerals 437

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