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New role of TIEG1 gene in mechanical muscle function

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HAL Id: hal-02154847 https://hal.utc.fr/hal-02154847

Submitted on 13 Jun 2019

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New role of TIEG1 gene in mechanical muscle function

Malek Kammoun

To cite this version:

Malek Kammoun. New role of TIEG1 gene in mechanical muscle function. Rencontre GDR MECABIO et Réparer l’humain, Nov 2018, Montpellier, France. �hal-02154847�

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New role of TIEG1 gene in mechanical muscle function

Malek Kammoun

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Sorbonne University, Université de Technologie de Compiègne, UMR CNRS 7338 Biomechanics and Bioengineering, Centre de Recherche de Royallieu, France

TGF inducible early gene-1 (TIEG1) is a member of the Krüppel-like family of transcription factors (KLF10). As TIEG1 is highly expressed in skeletal muscle, it was of interest to analyze the effect of TIEG1 gene deletion on the mechanical and ultrastructural properties. Twenty five muscle fibers were harvested from slow fiber (soleus) and fast fiber (EDL) from TIEG1

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and control mice.

Mechanical tests were performed and the dynamic and static stresses were

measured. The mechanical results demonstrate that TIEG1 deficiency alters

functional properties in a muscle-type specific manner. In parallel, TEM

analysis were realized and revealed for TIEG1

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/

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muscle: structural

disorganization, shorter sarcomeres, disappearance of I bands, changes in

mitochondrial shape and increase of myosin diameter. TIEG1 are tired more

quickly than controls mice in treadmill exercise. Our findings lay the

groundwork for better understanding the role of TIEG1 gene in muscle disease.

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