• Aucun résultat trouvé

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond

N/A
N/A
Info
Télécharger
Protected

Academic year: 2021

Partager "The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond"

Copied!
1
0
0

Chargement.... (Voir le texte intégral maintenant)

Texte intégral

(1)

The TNF Family of Ligands and Receptors:

Communication Modules in the Immune

System and Beyond

Catherine Dostert , Melanie Grusdat , Elisabeth Letellier , and Dirk Brenner 24 Oct 2018https://doi.org/10.1152/physrev.00045.2017 

 View Full Text

 PDF (792 KB)

 Tools

 Share

Abstract

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the modulation of cellular functions. The communication pathways mediated by TNFSF/TNFRSF are essential for numerous developmental, homeostatic, and stimulus-responsive processes in vivo.

TNFSF/TNFRSF members regulate cellular differentiation, survival, and programmed death, but their most critical functions pertain to the immune system. Both innate and adaptive immune cells are controlled by TNFSF/TNFRSF members in a manner that is crucial for the coordination of various mechanisms driving either co-stimulation or co-inhibition of the immune response. Dysregulation of these same signaling pathways has been implicated in inflammatory and autoimmune diseases, highlighting the importance of their tight regulation. Investigation of the control of TNFSF/TNFRSF activities has led to the development of therapeutics with the potential to reduce chronic inflammation or promote anti-tumor

Références

Télécharger maintenant ( DOCX - 1 Page - 14.75 KB )

Documents relatifs

Arsenic and the immune system

By analysing methylomics (target-enrichment next-generation sequencing) of human blood CD4+ T lymphocytes from arsenic-exposed Argentinean women, the investigators

The innate immune response of equine bronchial epithelial cells is altered by training

The relative mRNA expression of TLR1-9 (A,B) and four cytokines (IFN- β, TNF-α, IL-6, CXCL8) (C,D) was evaluated directly in bronchial biopsies (A,C) and in non-stimulated cultures

1-the innate or non-specific immune system 2-the adaptive or specific immune system

-immunological memory. It “remembers” that it has encountered an invading organism and reacts more.. rapidly on subsequent exposure to the same organism. 3-Each of the

In vivo visualization of cells labeled with superparamagnetic iron oxides by a sub-millisecond gradient echo sequence

A Cartesian sub-millisecond echo time SPGR 3D sequence was used and optimized for the in vivo visualization of SPIO- labeled PIs in the liver, in order to yield positive contrast

Guaranteed and robust a posteriori bounds for Laplace eigenvalues and eigenvectors: a unified framework

Key words: Laplace eigenvalue problem, a posteriori estimate, guaranteed eigenvalue bound, guaranteed eigenvector error bound, abstract framework, nonconforming finite element

Magnetic resonance imaging evidences of the impact of water sorption on hardwood capillary imbibition dynamics

viscosity allows to superimpose all data obtained for different oil viscosities along a master curve (see Figure 6), in agreement with the prediction of equations (4) or (6).

"Courage First" : dissent, debate, and the origins of US responsiveness to mass killing

The theory proposed in this dissertation argues that significant policy change has historically occurred within the United States when three factors converge:

Growth relationships between root and shoot in walnut seedlings (Juglans regia L.)

Growth relationships between root and shoot in walnut seedlings (Juglans regia L.).. Jean-Sylvain