• Aucun résultat trouvé

Accelerated postoperative radiation therapy with weekly concomitant boost in high risk patients with squamous-cell carcinoma of the head and neck


Academic year: 2021

Partager "Accelerated postoperative radiation therapy with weekly concomitant boost in high risk patients with squamous-cell carcinoma of the head and neck"

En savoir plus ( Page)

Texte intégral


$248 Friday/Saturday, 20-21 September 2002




inhomogeneity index that is within generally accepted limits. Of the eight

Accelerated postoperative radiation therapy with weekly con-

patients treated using this technique three patients had no change from

comitant boost in high risk patients with squamous-cell car-

baseline salivary gland function, while five patients reported slight dryness

cinoma of the head and neck

of mouth but had good response of salivary gland function upon stimulation,

Conclusions: Optical guided technology improves the accuracy of patient

M, Ozsahin 1, J. Chevalier 1, P. Pasche 2, P. Coucke 1, R.O. Mirimanoff 1,

localization relative to the linac isocenter and allows real-time monitoring of

A. Zouhair 1

patient position during treatment. These IMRT plans can be safely and

1Lausanne University Medical Center (CHUV), Radiation Oncology, Lau.

effectively delivered. IMRT planning provides the user the ability to confor-

sanne, Switzerland

mally avoid critical structures, It therefore, enhances the normal tissue spar-

ing as well as provides a high degree of conformality. Additionaly, optically

2Lausanne University Medical Center (CHUV), Otorhinolaryngology, L a u -

guided technology also provides improved interfraction patient localization

sanne, Switzerland

and online monitoring of patient position within a tolerance band ±0.3mm

translational error and ± 0.3-degree rotational error during treatment deliv-

Purpose: To assess the feasibility and efficacy of accelerated weekly 6 frac-

tionated 66oGy postoperative radiation therapy (RT) using a single fraction


regimen from Monday to Thursday and a concomitant boost in the Friday



afternoon sessions in patients with squamous-cell carcinoma of the head

and neck (SCCHN).

H i g h

dose rate interstitial brachytherapy for oropharynx can-


and methods: Between December 1997 and July 2001,68 (male


to female ratio: 52/16; median age: 60 years [range: 43-81]) consecutive

T. No__se

1, K. Yoshida 2, M. Koizumi 1, K. Nishiyama 1, T. Inoue 3

patients (refusing to participate to the EORTC 22931 study comparing post-


Medical Center for Cancer and Cardiovasdblar, Radiation Oncolo-

operative RT vs, RT plus chemotherapy) with pTl-pT4 and/or pN0-pN3

gy, Osaka, Japan

SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 2 maxil-

lary sinus, 2 salivary gland, and 3 unknown primary) were included in this

2Osaka National Hospital, Radiology, Osaka, Japan

prospective study. Postoperative RT was indicated because surgical mar-

3Osaka University, Radiation Oncology, Osaka, Japan

gins were not free of tumor in 20 (29%) patients, extranodal infiltration was

observed in 20 (29%) patients (both present in 23 [34%]), in two patients

Objective: To improve local control and to lessen external beam radiation

(3%) because of lymphangitis, and in 3 patients (5%) because of other rea-

sequelae, we started high dose rate interstitial brachytherapy in 1993.

sons. RT consisted of 66 Gy in 51/2 weeks. Prophylactic percutaneous

Patients and Methods: From 1993 through April 2001, we treated 51

endoscopic gastrostomy was applied in i 9 patients. Median follow-up was

lesions of oropharynx squamous cell carcinomas in 50 patients (45 males

15 months,

and five females). Based on Pernot's criteria, we classified 29 lesions as

Results: All but one patient (not finishing the treatment because of non

group A (soft palate, tonsil and posterior pillar carcinomas), 13 as group B

treatment-related reasons at 56 Gy) received the planned total dose without

(anterior pillar and glossotonsillar sulcus carcinomas) and nine as group C

unplanned interruption. Acute morbidity was acceptable: grade 3 mucositis

(base of tongue and vallecula carcinomas). Primary tumors are categorized

in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin

as T1; six, T2; 32, T3; 12 and T4; one. For implants, we applied Nancy

erythema in 21 (31%) patients, and a median weight loss of 3 kg was

school techniques. During implant, we inserted metal markers around the

observed (range: 0-16). No grade 4 toxicity was observed. Considering the

tumor to reconstruct CTV by X-ray films. At planning, we optimized dwell

late effects, grade 3 xerostomia was observed in 6 (8%) patients, grade 3

times manually with two principles. 1; An isodose surface as near to 85%

edema in 2 (0.2%) patient. In a median follow-up period of 13 months, only

basal dose as possible covers CTV. 2; Hyperdose sleeve smaller than 0.8

3 (4%) local and 4 (6%) regional relapses were observed, and 8 (12%)

cm. For dose prescription, we selected an isodose surface that covers the

patients developed distant metastases (all

reconstructed CTV. For the mandible protection, we used lead shields

Iocoregionally controlled), The 2-year overall and disease-free survival and

when indicated. All the 51 lesions were treated by hyperfractionated high

actuarial Iocoregional control rates were 85%, 73%, and 83%; respectively,

dose rate interstitial brachytherapy; 41 lesions in combination with external

Conclusion: We conclude that reducing the overall treatment time using

beam and 10 as monotherapy. Except early Cases, brachytherapy doses

postoperative accelerated RT by weekly concomitant boost (6 fractions per

were 18~30 Gy / 3-5 fr / 2-3 days following 45 Gy external beam for groups

week) is easily feasible with a good local control, and acute and late RT-

A and C while 48~54 Gy / 8-9 fr/5-7 days as monotherapy for group B. Fol-

related morbidity is highly acceptable. Given the disease progression pat-

low-up ranges from one through 81 months with the median 20 months.

tern (distant metastases), adjuvant chemotherapy should be considered.

Results: We achieved 85.7% of the five-year local control rate for the entire

group. Five-year cause specific and overall survivals were 85.5% and



57.9%. Transient soft tissue necrosis (mostly superficial erosion) was

O p t i c a l l y

guided intensity modulated radiotherapy for the

observed in 41.2% but none developed bone complications.

head and neck

Discussion: Compared to definitive external beam series, superior local

control was achieved. Xerostomia and taste loss seemed much improved.

R.R. Pate~ 1, W.A, Tom~ 1,2, S.P. Tannehi/I 1, P.M. Harari 1, B.R. Pa/iwa/1,2,

Compared to low dose rate interstitial series, local control and complications

M.P. Mehfa 1

were almost equivalent. Our principles for dose planning above were

1University of Wisconsin Medical Schoo/, Department of Human Onco/o-

sometimes difficult to achieve with uniform dwell time setting. Stepping

gy, Madison, U.S.A,

source technology enabled us to better conform CTV with avoiding exces-

sive hyperdose sleeve by changing dwell times manually.

2University of Wisconsin Medical School, Department of Medical Physics,

Conclusions: High dose rate interstitial brachytherapy can be the first-line

Madison, U.S.A.

treatment of oropharynx carcinomas with traditional implant techniques and

Purpose: In this work we report on the use of an optical guided system for

modern technology,

intensity modulated i~diotherapy (IMRT) to the Head and Neck.



Method: An IMRT treatment plan is generated using seven coplanar beams,

Accelerated radiotherapy combined with chemotherapy


spaced uniformly, every 40 degrees along a 240-degree arc starting at an

angle of 60 degrees and ending at an angle of 240 degrees, going counter

the treatment of anaplasti¢ carcinoma of the thyroid

clockwise using the IEC convention in the stereotactic space established by

R, De Crevoisier. E, Lartigau, E. T.,J,P. Baudin, M. Sch/umberger, C. Hale-

an optically guided system. The posterior 120-degree avoidance region is

Metier, F. EschwOge

necessary so that the treatment beams do not enter through a six-degree of

/nstitut Gustave-Roussy, Vi//ejuif, France

freedom couch mount used to position the patient. Treatment plans were

generated utilizing a novel, three-step optimization procedure that consists

Purpose : To analyze toxicity and efficiency of a protocol combining

of (a) finding an ideal mathematical solution to the inverse problem, (b) con-

surgery, chemotherapy and bi4ractionated radiotherapy (RT-CT) in

verting the ideal solution into MLC segments, and (c) optimizing the seg-

anaplastic thyroid carcinoma (ATC).

ment weights of all MLC segments for all beams simultaneously using the

Patients and methods : 32 ATC patients (pts) with a mean age of 60 years

objective function that was employed for the ideal inverse solution.

(40-79) were treated in a phase I-II trial between 1990-2001. Tumor extend-

Results: The use of an optical guided system in conjunction with the IMRT

ed beyond the capsule gland in 29 pts, with tracheal extension in 9. Lymph

treatment planning technique described above allows generation of highty

node metastases were present in 20 and lung metastases in 6. Surgery was

conformal Head and Neck treatment plans that exhibit conformal avoidance

performed before RT-CT in 22 and after RT-CT in 3 and tumor resection

of critical structures and adequate coverage of target structures with an

was macroscopieally complete in 14 pts. Two cycles of chemotherapy com-

bining doxorubicin (60 mg/m 2) and cisplatin (120 mg/m 2) every 4 weeks


Documents relatifs

Le ministre de l’économie active dès la situation 4B (ou plus tôt si nécessaire) la cellule de continuité économique et comprend des représentent de direction

As donor-derived cells were only found in female recipients of male kidney transplants, we performed a qPCR for ZFY gene on AK and SCC tissue sec- tions, which confirmed the presence

Objectif : Déterminer la performance de l’outil « ABCDEF » pour dépister la fragilité définie par les critères de Fried dans une population communautaire de 70 ans et plus et

Due to a lack of detailed data quality studies available about GEO600, similar to those performed for LIGO and Virgo, data from that detector were not used in this analysis,

Ces formes et formations sont attribuées à la période historique car elles sont très peu au-dessus de talwegs qui creusent très vite ; la seule formation

Treves et al., “ Clinical responses in a phase II study using adoptive transfer of short- term cultured tumor in fi ltration lymphocytes in metastatic melanoma patients, ”

In the preop group, overall treatment time is defined as the time between diagnosis and the day of last surgery, in the postop group between diagnosis and last irradiation

Proper coordination and control of cell division is critical to cells, and failure to properly manage the division process has severe consequences ranging from cell death to

This study assesses the prognostic relation between HIF1α, VEGF-A, EGF Receptor and CAIX expression by immunochemistry in diagnostic samples of patients with intermediate- and

To predict glucose at a 30-minute time horizon, we pro- cessed the raw features of the OhioT1DM dataset [Marling and Bunescu, 2018] to create 3 different feature sets, and

We predicted the hazard ratios for the primary end point with interleukin-2 therapy on the basis of the overall differences in the CD4+ cell count between the two treatment groups

The results suggested a greater treatment effect in subjects with nodular lung lesions and/or thick-walled cysts on chest HRCT, with diffuse hypermetabolism of lung lesions on

Despite improved management of concomitant heparin infusion, a closer surveillance of haemostasis, an increased knowledge in the risk factors for bleeding and finally, a

When splitting the results by T stage, in patients with T1–2 tumors, the global QoL score was similar in the two treatment groups, as well as the other parameters except the

In our series, only 54% of patients initially seen with stage I to II disease underwent salvage surgery, suggesting that the latter op- tion became nonfeasible in many patients who

Steady-state values during the identification phase and reactions to tilting and mobilization differed between healthy subjects and patients.. Failure of normal regulatory responses

While the latter has been addressed recently by the implementation of hydrogen isotope ratios (HIR), an improved sample preparation for CIR avoiding co-eluting compounds is

Consigne: «Je vais vous distribuer le doc.4 et vous allez vous en servir pour répondre aux questions. Fleurus se trouve en Belgique et cette bataille opposait l'armée française

This paper provides reviews of the most commonly used methods to detect plant pests belonging to groups of invasive organisms with high economic relevance, including Coleop- tera

Dans notre étude, le signe clinique le plus fréquent était la fièvre retrouvée chez presque tous les malades.. Cette fièvre est le plus souvent accompagnée

Direct Radiative Effect by Mineral Dust Aerosols Constrained by New Microphysical and Spectral Optical Data.5. Direct radiative effect by mineral dust aerosols constrained

in net evaporation over the Atlantic basin, local processes within the Atlantic basin as expressed by the density di fference between the northern and southern ends, or the

For the six items across the five year period, identified respondents tended to give more positive ratings (p < .001). There were no significant differences between anonymous