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Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion

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Academic year: 2022

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Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion

AROUS, Caroline, RONDAS, Dieter, HALBAN, Philippe A.

Abstract

Actin and focal adhesion (FA) remodelling are essential for glucose-stimulated insulin secretion (GSIS). Non-muscle myosin II (NM II) isoforms have been implicated in such remodelling in other cell types, and myosin light chain kinase (MLCK) and Rho-associated coiled-coil-containing kinase (ROCK) are upstream regulators of NM II, which is known to be involved in GSIS. The aim of this work was to elucidate the implication and regulation of NM IIA and IIB in beta cell actin and FA remodelling, granule trafficking and GSIS.

AROUS, Caroline, RONDAS, Dieter, HALBAN, Philippe A. Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion.

Diabetologia , 2013, vol. 56, no. 4, p. 792-802

DOI : 10.1007/s00125-012-2800-1 PMID : 23354122

Available at:

http://archive-ouverte.unige.ch/unige:28882

Disclaimer: layout of this document may differ from the published version.

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