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Cerebral hemodynamic and ventilatory responses to
hypoxia, hypercapnia, and hypocapnia during 5 days at
4,350 m.
Thomas Rupp, François Esteve, Pierre Bouzat, Carsten Lundby, Stéphane
Perrey, Patrick Levy, Paul Robach, Samuel Verges
To cite this version:
Thomas Rupp, François Esteve, Pierre Bouzat, Carsten Lundby, Stéphane Perrey, et al.. Cerebral hemodynamic and ventilatory responses to hypoxia, hypercapnia, and hypocapnia during 5 days at 4,350 m.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2014, 34 (1), pp.52-60. �10.1038/jcbfm.2013.167�. �inserm-00873387�
LEGENDS TO FIGURES IN ONLINE DATA SUPPLEMENT
Figure 1 online supplement. Hypoxic responses: Ventilatory (VE, panel A), TCD (TCD
CVR, panel B) and NIRS (oxyhemoglobin HbO2, panel C; tissue oxygenation index TOI,
panel D; deoxyhemoglobin HHb, panel E; total hemoglobin HbTot, panel F) responses to
isocapnic hypoxia at sea level (SL), at day 1 (D1) and 5 (D5) at altitude. Changes in VE, TCD
CVR and NIRS variables are expressed per % of change in arterial O2 saturation. *
significantly different from SL; + significantly different from D1.
Figure 2 online supplement. Individual hypoxic responses: Ventilatory (VE, panel A), TCD
(TCD CVR, panel B) and NIRS (oxyhemoglobin HbO2, panel C; tissue oxygenation index
TOI, panel D; deoxyhemoglobin HHb, panle E; total hemoglobin HbTot, panel F) responses
to isocapnic hypoxia at sea level (SL), at day 1 (D1) and 5 (D5) at altitude. Changes in VE,
TCD CVR and NIRS variables are expressed per mmHg of change in end-tidal O2 partial
pressure. Whiskers under and above the mean values (large horizontal lines) represent the
95% confident interval. * significantly different from SL; + significantly different from D1.
Figure 3 online supplement. Individual hypercapnic responses: Ventilatory (VE, panel A),
TCD (TCD CVR, panel B) and NIRS (oxyhemoglobin HbO2, panel C; tissue oxygenation
index TOI, panel D; deoxyhemoglobin HHb, panel E; total hemoglobin HbTot, panel F)
responses to hypercapnia (expressed per mmHg of change in end-tidal CO2 partial pressure) at
sea level (SL), at day 1 (D1) and 5 (D5) at altitude. Whiskers under and above the mean values (large horizontal lines) represent the 95% confident interval. * significantly different
Figure 4 online supplement. Individual hypocapnic responses: TCD (TCD CVR, panel A)
and NIRS (oxyhemoglobin HbO2, panel B; tissue oxygenation index TOI; panel C;
deoxyhemoglobin HHb, panel D; total hemoglobin HbTot, panel E) responses to hypocapnia
(expressed per mmHg of change in end-tidal CO2 partial pressure) at sea level (SL), at day 1
(D1) and 5 (D5) at altitude. Whiskers under and above the mean values (large horizontal lines) represent the 95% confident interval.
0 2 4 6 8 V E ( l.m in -1.% -1) *,+ 0 10 20 30 Δ H H b (µ m ol .c m .% -1) 0 10 20 30 Δ H bT ot ( µ m ol .c m .% -1) *,+ 0 2 4 6 8 T C D C V R ( % .% -1) n=5 * * -40 -30 -20 -10 0 Δ H bO 2 ( µ m ol .c m .% -1) -2.0 -1.5 -1.0 -0.5 0.0 T O I ( % .% -1) SL D1 D5 SL D1 D5
A
C
E
D
F
B
0 1 2 3 4 SL D1 D5 Δ H H b (µ m ol .c m .m m H g -1 ) -2 0 2 4 SL D1 D5 Δ H bT ot (µ m ol .c m .m m H g -1 ) 0.0 0.2 0.4 0.6 0.8 VE (l. m in -1 .m m H g -1 )
*
,+ 0.0 0.2 0.4 0.6 0.8 1.0 SL D1 D5 T C D C V R (% .m m H g -1)*
*
-5 -4 -3 -2 -1 0 SL D1 D5 Δ H bO 2 (µ m ol .c m .m m H g -1 )*
,+ -0.2 -0.1 -0.0 SL D1 D5 T O I ( % .m m H g -1 ) * p=0.07 SL D1 D5 SL D1 D5A
C
E
B
D
F
-5 0 5 10 SL D1 D5 Δ H H b (µ m ol .c m .m m H g -1) -15 -10 -5 0 5 SL D1 D5 Δ H bT ot (µ m ol .c m .m m H g -1 ) SL D1 D5 SL D1 D5
A
B
D
C
E
0 1 2 3 4 5 SL D1 D5 T C D C V R (% .m m H g -1 ) n=5 -20 -15 -10 -5 0 SL D1 D5 Δ H bO 2 (µ m ol .c m .m m H g -1) -0.8 -0.6 -0.4 -0.2 0.0 SL D1 D5 T O I ( % .m m H g -1 )-15 -10 -5 0 5 SL D1 D5 Δ H H b (µ m ol .c m .m m H g -1 ) * -20 0 20 40 SL D1 D5 Δ H bT ot (µ m ol .c m .m m H g -1 ) 0 3 6 9 12 VE (l. m in -1 .m m H g -1 )
