Conférence LCC
Pr Sylvestre Bonnet
Leiden University
Photoactivated chemotherapy with metal compounds
Vendredi 15 février 2019 à 11h00 Auditorium Fernand Gallais
Campus CNRS 205
205, route de Narbonne, Toulouse
Contact LCC: Dr Eric Manoury , eric.manoury@lcc-toulouse.fr
Retrouvez le programme complet des séminaires sur le site web du LCC : http://www.lcc-toulouse.fr/
PHOTOACTIVATED CHEMOTHERAPY WITH METAL COMPOUNDS
Sylvestre Bonnet
Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands E-mail: bonnet@chem.leidenuniv.nl
Photo-Activated Chemotherapy (PACT), like PhotoDynamic Therapy (PDT), aims at activating anticancer medicines with visible light to circumvent to the tumour site the toxicity of traditional chemotherapy. PACT agents are activated by photocleavage of a metal-ligand bond. While this type of photochemistry typically requires blue light, it is possible to obtain green or red light activation by playing photochemical tricks. In this presentation, several PACT compounds based on ruthenium will be presented that can be activated with blue, green, or red light. In some of them, it is the metal-based fragment that is responsible for the light-induced cytotoxicity, while in other cases it is the ligand that provokes cell death. As metal-ligand bond cleavage reactions do not require the presence of oxygen, PACT may allow for treating hypoxic tumours. We will close the lecture by showing our first results on PACT compounds tested in hypoxic conditions, ie, in cancer cells grown in presence of low dioxygen concentrations.
