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Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

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Academic year: 2021

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Figure 1  Effect of plecanatide and dolcanatide on lipopolysaccharide-induced increase in permeability of 4 kDa fluorescein isothiocyanate-dextran across  Caco-2 and T84 cell monolayers
Figure 2  Effect of plecanatide (A) and dolcanatide (B) on lipopolysaccharide-induced increased permeability of 4 kD fluorescein isothiocyanate-dextran  across rat colon tissues
Figure 3  Effect of plecanatide and dolcanatide on localization of occludin in epithelial cells
Figure 4  Effect of plecanatide and dolcanatide on localization of ZO-1 in epithelial cells Caco-2 (A) and T84 (B) cell monolayers were treated with 1  µ mol/L  plecanatide or dolcanatide in the presence of 100  µ g/mL of LPS for 16 h followed by immunoflu

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