Article
Reference
Periaqueductal efferents to dopamine and GABA neurons of the VTA
NTAMATI RWAKA, Niels, et al.
Abstract
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception.
Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.
NTAMATI RWAKA, Niels, et al . Periaqueductal efferents to dopamine and GABA neurons of the VTA. PLOS ONE , 2018, p. 1-11
PMID : 29304042 DOI : 10.1101/117416
DOI : 10.1371/journal.pone.0190297 DOI : 10.1371/journal.pone.0219476
Available at:
http://archive-ouverte.unige.ch/unige:100745
Disclaimer: layout of this document may differ from the published version.
1 / 1
CORRECTION
Correction: Periaqueductal efferents to dopamine and GABA neurons of the VTA
Niels R. Ntamati, Meaghan Creed, Ridouane Achargui, Christian Lu¨ scher
The following information is missing from the Funding statement: Funding was provided by the European Research Council (ERC Advanced grant MeSSI).
Reference
1. Ntamati NR, Creed M, Achargui R, Lu¨scher C (2018) Periaqueductal efferents to dopamine and GABA neurons of the VTA. PLoS ONE 13(1): e0190297.https://doi.org/10.1371/journal.pone.0190297PMID:
29304042
PLOS ONE |https://doi.org/10.1371/journal.pone.0219476 July 3, 2019 1 / 1
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
OPEN ACCESS
Citation: Ntamati NR, Creed M, Achargui R, Lu¨scher C (2019) Correction: Periaqueductal efferents to dopamine and GABA neurons of the VTA. PLoS ONE 14(7): e0219476.https://doi.org/
10.1371/journal.pone.0219476
Published: July 3, 2019
Copyright:©2019 Ntamati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
