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delta biotech

Buenos Aires, September 29, 2015 Letter of commitment

To whom it may concern

The Delta Biotech S.A. certifies that all operations, procedures, materials and specifications will be in conformance with the Active Substance Master File.

The aforementioned Active Substance Master File holder commits to ensure batch to batch consistency and to inform Pharmathen and concerned health authorities any changes connection with in the Active Substance Master File.

Delta t~iotech S.A.

Armenia 3881- (B1605CEI) • munro Pcia. de Buenos Aires -Argentina Tel./Fax: (5411) 4700-8025 {rotativas) info@deltabiotech.com.ar - www.deltabiotech.com.ar

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The af orementioned Active Substance Master File holder hereby authorizes the ANSM, to refer to and review the above mentioned Active Substance Master File in

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