Molecular characterisation of the recombinant Vesicular Stomatitis Virus- ZEBOV-GP virus, prototype vaccine against Ebola virus

Texte intégral

(1)Molecular characterisation of the recombinant Vesicular Stomatitis Virus- ZEBOV-GP virus, prototype vaccine against Ebola virus Nicolas Danet. To cite this version: Nicolas Danet. Molecular characterisation of the recombinant Vesicular Stomatitis Virus- ZEBOV-GP virus, prototype vaccine against Ebola virus. Virology. Université de Lyon, 2019. English. �NNT : 2019LYSE1009�. �tel-02125352�. HAL Id: tel-02125352 https://tel.archives-ouvertes.fr/tel-02125352 Submitted on 10 May 2019. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) N° d’ordre NNT : 2019LYSE1009. . THÈSE de DOCTORAT DE L'UNIVERSITÉ DE LYON opérée au sein de. l’Université Claude Bernard Lyon 1 . Ecole Doctorale N° 340 Biologie Moléculaire Intégrative et Cellulaire . Spécialité de doctorat : Virologie Discipline : Biologie moléculaire Soutenue publiquement le 01/02/2019, par : Nicolas DANET . Molecular characterisation of the recombinant Vesicular Stomatitis VirusZEBOV-GP virus, prototype vaccine against Ebola virus Devant le jury composé de : . Jamin Marc, Professeur, Institut de Biologie Structurale - CEA Grenoble, Rapporteur et Président du jury. Blondel Danielle, Directeur de Recherche CNRS, Institut de Biologie Intégrative de la Cellule Université Paris-Saclay, Rapporteuse. Gonzales-Dunia Daniel, Directeur de Recherche CNRS, Centre de Physiopathologie Toulouse-Purpan - Université de Toulouse, Examinateur.. . Manet Evelyne, Directrice de Recherche CNRS, Centre International de Recherche en Infectiologie - Université Claude Bernard Lyon 1, Examinatrice. . . Gilbert Christophe, Maître de Conférences UCBL, Centre International de Recherche en Infectiologie - Université Claude Bernard Lyon 1, Examinateur. . Volchkov Viktor, Professeur UCBL, Centre International de Recherche en Infectiologie, Directeur de Thèse. . . . . g.

(3) . h.

(4) . . . i.

(5) . 9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999I

(6)

(7) 9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999K 999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999M 9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FG 99999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FH. 99999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FI 6 4 7777777777777777777777777777777777777777777777777777777777777777777777777HK "($'%'&$%.......................................................................................................................................25 $!% %%"!!$%&"$%.......................................................................................................................28 &'$!!&"%&%""($'%%..................................................................................................29 64 7777777777777777777777777777777777777777777777777777777777777777777777777777777777777II $"!!!" "$!%&"!..................................................................................................................33 $!%$#&"!!$#&"!$'&"!......................................................................................................34 $+!!'"#%%% +...................................................................................................36 "($'%#$"&!%......................................................................................................................................39 -$'(*',!&7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777IO JL777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777IP KG777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JG $1'(*',!&777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JI *&+*!(,!'&$!,!&7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JI '$-$77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JJ U:(,!777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JK -$$:$&, H4I77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JL 77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JN. &+! ,+!&,'HN+ !&% &!+%777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777JO JG77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KG IK77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KH (&&,:'$1%*+ 77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KJ. 6 777777777777777777777777777777777777777777777777777777777777777777KK "($'%%%#&"!%%.................................................................................................................55. !!&!#&( '!$%#"!%+%$'&"!%'$!"($'%!&"!...................................59 , '&,,!'&7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KO. %%-&$$+**-!,%&,777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KO +'$-,!'&', !&,!'&77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777KP ,-*&,' '%'+,+!+77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LG. "'&"!%"$$%...................................................................................................................................63 0,*!&+!(, /17777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LI. &,*!&+!(, /177777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LJ ,!&&'%($%&,(, /1+77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LK. 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LN %%( '!%&"!...................................................................................................................................68 $& '!%&"!.....................................................................................................................................68. &,!.,77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LN .!&+77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LN !*-+:$!#(*,!$+777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LO ($!,!'&:,!.&;'%(,&,.!&+77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LO ($!,!'&:,!..!&+777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LO '!!!&&#*!*-++.!&+777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LO '%!&&,&2-$&)-!&&( $!,!+!*-+<=*($!'&77777777777777777777777777777777777777777777777777777777777777LO

(8) -&"!&.!*-++:.!&77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LO *'%!&&,UJG777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LP ($!,!'&:'%(,&,.!&+7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LP. . j.

(9) -%&(*!&$-&2.!*-+,1(J< J=7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LP '%!&&,&'.!*-+L<*L=77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777LP '%!&&,+!-$*,'%,!,!+!*-+<*=777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777MG.

(10)

(11) <U<< 7

(12) 99999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999KI 7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777MK 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777MM 2-3;$%$" $/!&%..........................................................................................77 $// ($'%$%'...............................................................................................................................7: !&$%"2-3;$" !&%..................................................................................................82. !&&"!"'+ &'$+"%+&3'$!$/!&"!.................................................84 * !&"!"2-3! 28%#&%&$'&"!'$!$/!&"!.............................8: &'+"2-3!2-3/&$!%#"$&&"&#% $!..................................................................92 2-3!2-3/"%&"!&&#% $!.............................................................................94. !(%&&"!"2-3/!"#"$&"!!&"($#$&%.............................................................................96 %"%"$%%/#$"'&'$!$/!&"!.....................................................................99 28&(&"!'$!$/!&"!..............................................................................................:1 $&$%&"!"$//

(13) !0 '&!&%........................................................................................:5 7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777PO 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HGN.

(14) 7 99999999999999999999999999999999999999999999FFG 77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HHI 7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HHJ. !&&"!"!&/

(15)

(16) !&"%!' !%!! %$......................................................224 ("# !&"

(17)

(18) !/%#' !*%%+.........................................................................226 !%$% #%$!!.....................................................................................................................22:

(19) ' !*&"!$ &"!+!$& '!'"$%!%%+.............................................................235 !% #!&$#...................................................................................................................................237. !&&"!"!) $'($'%%!"'%&&'%+#&'%&%.........................................................241 77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HJJ 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HJN

(20) 999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FHN

(21) 99999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FIL 9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FJK :: H4IU 77777777777777HLM. :7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777HMH

(22) 9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999FKM. . . . k.

(23) #!.+=5"2%(!'#-+( -"%! &#%25MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgj #!.+>5(%/#+.,(.-+$,&)5MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgk #!.+?5#%(/#+.,-+',&#,,#('2'&#,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhg #!.+@5%-+('&#+(,()2)#-.+,( #%(/#+.,/#+#(',MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhh #!.+A5!'(&,-+.-.+MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhi #!.+B5!'(++,(+!'#,-#(''%+,-+.-.+MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhk #!.+C5,,&%2'/#+%+%,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhl #!.+D5'.%(),#,-+.-.+MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhm #!.+E5,,&%2'+!.%-#('.+#'!,2'-",#,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhn #!.+=<5+2,-%,-+.-.+( ?A# '6#'"##-(+2(&#'MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMho #!.+==5@<(%#!(&+#,-#(''#'-+-#('0#-"-"%%.%+)%,&&&+'MMMMMMif #!.+=>5@<(-&+#+#'! (+&-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMig #!.+=?5-+',+#)-#('%#-#'!MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMih #!.+=@5(%.%,-+.-.+',2'-",#,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMii #!.+=A5F6))-#,-+.-.+MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMij #!.+=B5!%2()+(-#'=4>MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMik #!.+=C5&#- .,#('&(%MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMil #!.+=D5=4>F,-+.-.+MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMim #!.+=E5 =C)(,-6-+',%-#('+!.%-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMio #!.+><5(%( ?<#'/#+%-+',+#)-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMjf #!.+>=5>@6)''-'.%(),# (+&-#(''#'-+ +(''-!('#,&MMMMMMMMMMMMMMMMMjh #!.+>>5)-"(!',#,(/+/#0MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMjk #!.+>?5%#'#%(.+,( #' -#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMjl #!.+>@5#,,.-(+6)''-1-+#',#(!.%-#('-#/-#(''#'-+)%20#-" #' %&&-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMki #!.+>A5

(24) '#(%#',-+.-.+5MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMkk #!.+>B5=*,-+.-.+''-#(26)''-'"'&'-MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMkl #!.+>C5"$!###"!$"!'(&#(+!'#,-#('',-+.-.+5MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMlf #!.+>D5/+,'-#,2,-& (+-"!'+-#('( +(&#''-"$!###" !$""9+:MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMlh #!.+>E5'%2,#,( =4>;+%, +(&+6#' -%%,5MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMln #!.+?<5(&)+#,('( =4>;+%, ##'2-0'+6'+66 /#+.,,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMmf #!.+?=5 #'-#( =4>;+%, +(&+6#' -%%,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMmh #!.+?>5,2'-",#,'!%2(,2%-#(',MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMmj #!.+??5%2(,2%-#(''%2,#,( ,(%.%(+&&+'6(.'+%,.+#'! +6#' -#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMmn #!.+?@5)-#%#,-+#.-#('( =C'=4>#'+6#' -%%,MMMMMMMMMMnf #!.+?A5+!'%%,,)+-#(' +(&+6#' -%%,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMni #!.+?B5-+!'-6,',#-#/'8+,#,-'-&&+',)+-#(' +(&+6 #' -%%,5MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMnj #!.+?C5%2()+(-#'!%2(,2%-#(')--+','%2,#, +(&+66

(25) #' -%%,5Mnm #!.+?D5,(%.%!%2()+(-#',+%,-"+(.!"#-#'!.+#'!+6 #' -#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMof #!.+?E5(%( =C#'=4>F+%,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMoh #!.+@<5 =7>')?D.)+!.%-#('.+#'!'+6#' -#(''+(%( )"(,)"-#2%,+#'1)(,.+#',"#'!('-+(%MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMoj #!.+@=5(&)+#,('( +646

(26) '8 /#+.,,#' -#/#-2MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMom #!.+@>5 (% (+,"#'!('-+(%MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgfk . l.

(27) #!.+@?5,2'-",#,.+#'!+6#' -#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMggf #!.+@@5 '#+-#&&.'( %.(+,''%2,#,( !"''#'".&',+MMMMMMMMMMMMMMMMMMMMMMMMMggk #!.+@A5'

(28)

(29) F 6 #,6-!!&.-'-,!%2(,2%-#(','%2,#,MMMMMMMMMMMMMMMMMMggm #!.+@B5'-#!',(.)%#'!(' #+&-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMggo #!.+@C5"'#',+,+''#'!MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMghj #!.+@D5(' #+&-#('( %.&#'1+,.%-,2#'#+-#&&.'( %.(+,''%2,#,MMMMghk #!.+@E5&)%#'!%(%#,-#(''%(+-(+#,#',-%%-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMghm #!.+A<5!',#3#,-+#.-#('( '$"''& #$",&)%-,MMMMghn #!.+A=51-+-#(''%2,#, +(&"'#'(+!',,-(+#'%-+MMMMMMMMMMMMMMMMMMMMMMgho #!.+A>5 +.+!/#+.,6%#$,*.',#'-# #-#('''%2,#,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgih #!.+A?5+6.%-+ #%-+-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgkm #!.+A@5+6''( #%-+-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMglf #!.+AA5%-%--#/-#('2# +'-%%.%+&#MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMglh #!.+AB5'%2,#,( 0,")%-%-,-#/-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMglj #!.+AC5#+.,)+(.-#(' (+)%-%-,-#&.%-#('MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMglj #!.+AD5'0,")%-%-,,-#&.%-#('0#-"+6'MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgll #!.+AE5%-%--#/-#(' (%%(0#'!,-#&.%-#('0#-"# +'-&(.'-( MMMMMMMMMMMMMglm %=5(%/#+.,(.-+$,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgl %>5-,)#,#'- ##,)(-'-#%+,+/(#+,( #%(/#+.,,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMhf %?5'#-/#',!#',-(%/#+.,MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMli %?56'',-('#-#(',MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMgjj . . . m.

(30) • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •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kLFH=B?B>=!:@E>k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n.

(31) • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •. . #,<EE>:O>=#, #/#>G>/M:KM #/#>G>LM:KM $//$:GDLk;:E:G<>=L:EMLHENMBHG $>2$>G=K:OBKNL $BL$BLMB=BG>M:@ $%2$NF:GBFFNGH=>?BG<ROBKNL $'$B@AFHE><NE:KP>B@AMDBGBGH@>G $( .$NF:GE>NDH<RM>:GMB@>G .BLHMRI> $,%2$NF:GI:K:BG?EN>GS:OBKNLMRI> $. $>IM:=>K>@BHGn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o.

(32) • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •. . )%, o q):<KHIA:@>BG?E:FF:MHKRIKHM>BGo q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c=H<MHK ,',K>D:EEBDK>BG ,*#",>IMB=>* @ER<HLB=:L>" ,,,,E:M>E>M IHHKIE:LF: ,K> #,,K><NKLHK#ER<HIKHM>BG ,K> #,!.,K><NKLHK@ER<HIKHM>BG>G=HIE:LFB<K>MB<NENF ,K> L#,,K><NKLHKLHEN;E>#ER<HIKHM>BG ,.,,E:M>E>M KB<AIE:LF: ,..,:MAH@>GK><H@GBMBHGK><>IMHK ,/,AHLIA:MB=REL>KBG> J.0 ,.JN:GMBM:MBO>.>MKHMK:GL<KBIMBHG,HERF>K:L>A:BG.>:<MBHG ..HNLL>MNL:>@RIMB:<NL K=.><HF;BG:GM=>GHOBKNL .*'(.><>IMHK:<MBO:MHKH?GN<E>:K?:<MHKD:II: ;EB@:G= .22.:OGOBKNL ..>=;EHH=<>EEL . .><>IMHK;BG=BG@=HF:BG K!+2.><HF;BG:GM!+2 .!/02.>LMHG>;HE:OBKNL .%# %.>MBGHB<:<B= BG=N<B;E>@>G>% .(..B@ %EBD>K><>IMHK gf.

(33) • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •. . K)(K><HF;BG:GM)( .*.B;HGN<E>HMB=><B= K*,<.><HF;BG:GMG>F:MH=>:GMB<H:@NE:GMIKHM>BG< .*,.B;HGN<E>H<:ILB= K.*.B;HLHF:E.* .0.>MKHMK:GL<KBIMBHG K2/2 (/2#,K2/2 (:LL:OBKNL@ER<HIKHM>BG K2/2 #, $/K2/2 #,$B@ALA>=FNM:GM K2/2 #, (/K2/2 #,(HPLA>=FNM:GM K2/2 6!+2K><HF;BG:GM2/2 6!+2 /><</!AHFHEH@ L#,/HEN;E>#, L%( ./HEN;E>BGM>KE>NDBG>K><>IMHK LB.*LF:EEBGM>K?>KBG@.* /*,/BG@E>*N<E>HMB=>,HERFHKIABLF /,*0/NI>KG:M:GM LL#,/NI>KLF:EE#, L0*" ./HEN;E>0NFHKG><KHLBL?:<MHKK><>IMHK /1 2/N=:G>;HE:OBKNL 0!0*"o <HGO>KMBG@>GSRF> 0"20:Y"HK>LM>;HE:OBKNL 0% 0BLLN><NEMNK>BG?><MBO>=HL> 0"0BLLN>":<MHK 0@L0NFHKLNL<>IMB;BEBMR@>G> 0%),0BLLN>BGAB;BMHKH?F>M:EEHIKHM>BG:L> 0(.0HEE EBD>K><>IMHK 0)0K:GLF>F;K:G>=HF:BG 0*"o0NFHKG><KHLBL?:<MHKo 0.%(0*" K>E:M>=:IHIMHLBL BG=N<BG@EB@:G= 0.,0AKHF;BGK><>IMHK:<MBO:MHKI>IMB=> 11EMK:<>GMKB?N@>=LNI>KG:M:GM b@)B<KH@K:FL 10.1GMK:GLE:M>=K>@BHGL 2) 2:L<NE:K<>EE:=A>LBHGIKHM>BG 2!!22>G>SN>E:G>JNBG>>G<>IA:EBMBLOBKNL 2>KH!2>K=:K>GH! 2(,2BKNL EBD>I:KMB<E> 2,2BK:EIKHM>BG 2,*,,2,*,BG=BG@,>IMB=> O,),2BK:EI:MAH@>G:LLH<B:M>=FHE><NE:KI:MM>KG 2.,2>G>SN>E:G>JNBG>>G<>IA:EBMBLOBKNLK>IEB<HG 2/22>LB<NE:KLMHF:MBMBLOBKNL 3:LA>=,(03:LA>=IE:M>E>ML 303BE= MRI> 33,33=H:BG<HGM:BGBG@!N;BJNBMBGIKHM>BGEB@:L> 50RKHLBG> oEIA: q>M: p >EM: gg.

(34) !;HE:OBKNL!+2>LMNG?BEHOBKNLK>LIHGL:;E>=>?BWOK>LAVFHKK:@BJN>LOBK:E>LLVOWK>L<A>S EkANF:BG JNB I>NO>GM XMK> EVM:E>L =:GL =>L <:L

(35) (k:<MN>EE> VIB=VFB> >G .VIN;EBJN> VFH<K:MBJN>=NHG@H>MEk:FIE>NK=VF>LNKV>=>EVIB=VFB>=> >G?KBJN>=> Ek+N>LM JNB:<:NLVE:FHKM=>IENL=>I>KLHGG>L HGMIHNLLVE>L:@>G<>LL:GBM:BK>L BGM>KG:MBHG:E>L U M>LM>K IENLB>NKL :IIKH<A>L MAVK:I>NMBJN>L :?BG =k>LL:R>K =k>G=B@N>K K:IB=>F>GME:IKHI:@:MBHGOBK:E>>M=>EBFBM>KE:FHKM:EBMVEBV>:NOBKNLEHKL=>?NMNK>LVIB=VFB>L

(36) ,:KFBMHNM>LE>LLMK:MV@B>LM>LMV>L E>OBKNLK><HF;BG:GMKVIEB<:MB?K2/2 6!+2JNB>QIKBF> E:@ER<HIKHMVBG>=>LNK?:<>=k!+2 L>F;E>H??KBKE:F>BEE>NK>IKHM><MBHG :NLLB;B>G>GFH=WE> :GBF:EB>KL JN> LNK E> M>KK:BG

(37) O:GM =kXMK> M>LMV <A>S EkANF:BG => GHF;K>NL>L VMN=>L HGM I>KFBL => F>MMK> >G VOB=>G<> Ek>??B<:<BMV >M EkBGGH<NBMV => <> O:<<BG IKHMHMRI>

(38) ,HNKM:GM >M F:E@KV E> ?:BM JN> => GHF;K>NL>L VMN=>L HGM =VFHGMKV EkBFIHKM:G<> >M E> KZE> => E: @ER<HIKHMVBG>#,=:GLEk>??B<:<BMV=>LO:<<BGL<HGMK><>OBKNL :N<NG>VMN=>Gk:>G<HK>VMV KV:EBLVLNKE:G:MNK>=>L@ER<HIKHMVBG>LOBK:E>LLRGMAVMBLV>LI:KE>@WG>#,=k!+2BGLVKV =:GLE>@VGHF>=NOBKNL2/2

(39) BGLB E>L<:K:<MVKBL:MBHGLFHEV<NE:BK>L=>LIKHMVBG>LOBK:E>L IKH=NBM>LEHKL=>EkBG?><MBHGI:KE>OBKNLK2/2 #,=V<KBM>L=:GL<>LMK:O:NQ=>MAWL>H??K>GM=> GHNO>EE>LI>KLI><MBO>LIHNK<HFIK>G=K>E>LN<<WL=><>O:<<BGF:BL:NLLBEkHKB@BG>OBK:E>L =:GL E>L >??>ML L><HG=:BK>L LVOWK>L H;L>KOVL EHKL => E: O:<<BG:MBHG >M IHNKKHGM :B=>K U =VO>EHII>K NG O:<<BG IENL L[K JNB Gk>LM :<MN>EE>F>GM I:L NMBEBL:;E> <A>S E>L I>KLHGG>L BFFNGH=VIKBFV>L

(40) )HML<E>?L!($'% K2/2 6!+2 O:<<BG @ER<HLRE:MBHGL )"&'% $'$($'%

(41) . . . gh.

(42) 0A>?BEHOBKNL!;HE:OBKNL!+2BLMA><:NL:MBO>:@>GMH?L>O>K>OBK:EA:>FHKKA:@B<?>O>KLBG ANF:GLMA:M<:G;>E>MA:EBGH?<:L>L

(43) 0A><NKK>GMHNM;K>:DBGMA> >FH<K:MB<.>IN;EB< H?HG@H:G=MA>>QMK:HK=BG:KRL<:E>H?MA> HNM;K>:DBG3>LM?KB<: MA:M<:NL>= MA>=>:MAH?FHK>MA:G=BL>:L>OB<MBFL E>:=MA>BGM>KG:MBHG:EIN;EB<A>:EMA:@>GLMH M>LML>O>K:EMA>K:I>NMB<:IIKH:<A>LMHEBFBMOBK:ELIK>:=BG@:G=FHKM:EBMR

(44) FHG@LMMAHL> MA> K><HF;BG:GM K>IEB<:MBHG <HFI>M>GM K2/2 6!+2 OBKNL MA:M >QIK>LL>= !+2 #, @ER<HIKHM>BG :II>:KLMHH??>KMA>;>LMIKHM><MBHGBG:GBF:EFH=>EL:G=HNM;K>:DL>MMBG@L

(45) 3ABE> BML >??><MBO>G>LL :G= L:?>MR A:O> ;>>G PB=>ER BGO>LMB@:M>= ;>?HK> ANF:G MKB:EL :G= =>LIBM> GNF>KHNL LMN=B>L MA:M LAHP>= MA> BFIHKM:G<> MA> G:MNK> H? MA> @ER<HIKHM>BGL PAB<A :K> IKH=N<>==NKBG@MA>BG?><MBHG?KHFMA>!+2#,@>G>MA:MA:L;>>GBGL>KM>=BG2/2@>GHF> :K> NGDGHPG

(46) %G MABL K>LI><M MA> FHE><NE:K <A:K:<M>KBL:MBHG H? MA> OBK:E @ER<HIKHM>BGL LRGMA>LBL>= =NKBG@ K2/2 #, IK>L>GM>= BG MABL MA>LBL H??>K G>P BGLB@AML PBMA PAB<A MH NG=>KLM:G= MA> LN<<>LL H? MA> K2/2 #, O:<<BG> ;NM :ELH MA> IHM>GMB:E OBK:E HKB@BGL H? MA> L>O>K>:=O>KL>LB=>>??><MLH;L>KO>==NKBG@O:<<BG:MBHG:G=<HNE=A>EIBG=>O>EHIBG@:L:?>K O:<<BG> PAB<A<NKK>GMER<:GGHM;>NL>=BG:GBFFNGH<HFIKHFBL>=IHINE:MBHG

(47) '>RPHK=L!($'% K2/2 6!+2 O:<<BG> @ER<HLRE:MBHGL )"&'% $'$($'%. . gi.

(48) L J

(49) !;HE:OBKNLBL:G>GO>EHI>= GHG L>@F>GM>=LBG@E> LMK:G=>=G>@:MBO> .*OBKNLMA:MP:L?BKLM BLHE:M>=BG?HEEHPBG@HNM;K>:DLBG/HNMA/N=:G:G=6:BK>GHPMA> >FH<K:MB<.>IN;EB< H?HG@H78

(50) %MBL:SHHGHMB<OBKNL:G=MA><:NL:MBO>:@>GMH?!;HE:OBKNL=BL>:L>!2 : L>O>K>=BL>:L>BGANF:GL:G=GHG ANF:GIKBF:M>L*$,PBMA:?:M:EBMRK:M>MA:M<:GK>:<A BG LHF> HNM;K>:DL

(51) L MA>K> :K> <NKK>GMER GH O:<<BG> HK MA>K:I>NMB< :IIKH:<A>L :IIKHO>= !;HE:OBKNLBL:F:CHKIN;EB<A>:EMA<HG<>KG

(52) !;HE:OBKNLBLI:KMH?MA>!($'%@>G>K: PAB<A:EHG@LB=> $'$($'%:G='(($'% <HFIHL>MA>"BEHOBKB=:>?:FBER"B@

(53)

(54) 0A>R:K><NKK>GMER?BO>K><H@GBL>=@>G>MB<:EER=BLMBG<M LI>L H? !;HE:OBKNL $ !($'% !+2 ' !($'% /1 2 * !$%& !($'% 0"2 ' ')! !($'% 1 2 :G= %&! !($'% .!/02

(55) ):K;NK@OBKNL BL <HFIHL>= H? : LBG@E> LI>L $'$ $'$($'% PBMA MPH F>F;>KL ):K;NK@ OBKNL ).2 :G= .:OG OBKNL .22

(56) "BG:EER =BL<HO>K>= BG N>O:OBKNL BL ?HKF>=H?:NGBJN>LI>L

(57) !(''(($'%((+27 8

(58) . =5

(59)

(60) 5 0%*! ".+) Zo[M $5(+#!*!0% 0.!! .!,.!/!*0%*# 0$! 0$.!! )&+. %(+2%.1/ #!*!.L +(2%.1/J .1.#2%.1/ * 1!22%.1/M +(2%.1/ %/ +),+/! +" "%2! /,!%!/L %.! !+(2%.1/ XYJ 1 * !+(2%.1/XYJ%+.!/0!+(2%.1/XYJ1* %1*#5+!+(2%.1/XY* !/0+*!+(2%.1/ XYM.1.#).1.#2%.1/XY* 2*2%.1/XY.!"+.)%*#0$!.1.#2%.1/#!*1/* (+2%12%.1/J0$!1!22%.1/#!*1/M$!/(!..!,.!/!*0/!2+(10%+*.5 %/0*!!03!!*!$*+ !M . . gj.

(61) /BG<>MA>?BKLM?BEHOBKNLHNM;K>:DBG <:NL>=;R).2 ?HKMR=B??>K>GMHNM;K>:DLA:O>;>>G K><HK=>= PBMA MA>BK F:CHKBMR ;>BG@ <:NL>= ;R HG> H? MA> ?BO> LI>L H? !;HE:OBKNL

(62) /H ?:K ((+2A:LGHM<:NL>=:GRHNM;K>:DBGANF:GL;NMP:L=>M><M>=HGERBG=>:=BGL><MBOHKHNL ;:ML 0:;E>

(63) 0A> F:CHKBMR H? MA> HNM;K>:DL H<<NKK>= BG >GMK:E :G= /HNMA ?KB<: PAB<A LN@@>LML MA:M ?BEHOBKNL>L :K> >G=>FB< H? MA>L> K>@BHGL

(64) $HP>O>K MA> HNM;K>:D MA:M H<<NKK>= BG 3>LM ?KB<: MA> BLHE:MBHG H? .!/02 ?KHF BG?><M>= FHGD>RL BFIHKM>= ?KHF MA> ,ABEBIIBG>L MA>B=>GMB?B<:MBHGH?((+2BGMA>GHKMAH?/I:BG:G=BMLK> >F>K@>G<>BGBG $NG@:KR :LP>EE:LMA>=>M><MBHGH?I:KMB:E.*L>JN>G<>LH??BEHOBKNL>LBG<>GMK:EABG: :K> BG<K>F>GMBG@ >E>F>GML IHBGMBG@ HNM MA:M "BEHOBKNL>L :K> GHM K>LMKB<M>= MH >GMK:E :G= /HNMA ?KB<::LBGBMB:EERMAHN@AM"B@

(65) 7f8

(66) 0A>BG<K>:LBG@GNF;>KH?!;HE:OBKNLHNM;K>:DLLBG<> A:L;>>GLN@@>LM>=MH;><:NL>=;R:G:N@F>GM:MBHGH?:<<B=>GM:E<HGM:<ML;>MP>>G ANF:GL :G= MA> G:MNK:E HK :FIEB?RBG@ AHLML H? MA> OBKNL H<<NKK>G<>L H?M>G :LLH<B:M>= PBMA <>KM:BG LH<B:E :G= ><HGHFB< :<MBOBMB>L LN<A :L =>?HK>LM:MBHG ANGMBG@ :G= ;NLAF>:M <HGLNFF:MBHG7f8

(67) . >5

(68) 5 0%*! ".+) Zgk[M + %"%! ), +" ".% /$+3%*# 0$! 0! * 0$! (+(%/0%+* +" 0$! %""!.!*0 +(2%.1/+10.!'/M$!..+3/.!.!,.!/!*0%*#0$!$1)*)+2!)!*0/0$0(! 0+0$!!4,+.00%+*+" 0+ %""!.!*0+1*0.%!/J 1.%*#0$!hfgj+10.!'J* 0$!!*%.(! *1)!.0$!*1)!.+"//+%0! /!/M. gk.

(69)

(70) =5

(71)

(72) 5 + %"%! ".+)Zo[M. . . gl.

(73)

(74) *$,:K>AB@AERLNL<>IMB;E>MH!+2BG?><MBHG:G=:K><HFFHGERNL>=:L:FH=>EH?ANF:G MK:GLFBLLBHG

(75) %M A:L ;>>G LAHPG MA:M *$, <HNE= ;> BG?><M>= MAKHN@A HK:E <HGCNG<MBO:E LN;FN<HL:E:G=K>LIBK:MHKRKHNM>L7 8

(76) *$,BG?><MBHGLMN=B>L:ELHLAHP>=MA:M!+2BL AB@AERBG?><MBHNL:G=MAHL><RGHFHE@NLF:<:JN>LP>K>:;E>MHLN<<NF;MHMA>BG?><MBHGPA>G >QIHL>=MHO>KREHP=HL>H?BG?><MBHNLOBKNL?KHF

(77) ,"1MH,"1,E:JN>"HKFBG@1GBM 78

(78) %GANF:GL MA>HO>K:EE<:L>?:M:EBMRK:M>".H?!;HE:OBKNLK:G@>L?KHFMH =>I>G=BG@ HG MA> LI>L !+2 ;>BG@ MA> FHLM E>MA:E :G= PBMA MA> >Q<>IMBHG H? .!/02 PAB<ABL<HGLB=>K>=MH;>:LRFIMHF:MB<BGANF:GL !+2:II>:KLMH;>MA>E>LLI:MAH@>GB< H?MA>?BO>DGHPG!;HE:OBKNLLI>L

(79) "HK):K;NK@OBKNL MA>".BL:KHNG=78

(80) :L>= HG MA> *$, LMN=B>L :G= K>MKHLI><MBO> :G:ERLBL H? >IB=>FBHEH@B<:E =:M: H? <A:BG H? MK:GLFBLLBHGL %MBLGHP<E>:KMA:M!+2BLFHLMERMK:GLFBMM>=;>MP>>GANF:GLMAKHN@A=BK><M >QIHLNK>PBMA:GBG?><M>=I>KLHGHK=BL>:L>OB<MBFMAKHN@A;KHD>GLDBGHKFN<HNLF>F;K:G>L 7 8

(81) NKBG@MA>:<NM>IA:L>H?MA>BEEG>LL MA>OBKNLBLIK>L>GM:MAB@AMBMM>KLBG=B??>K>GM;H=BER ?ENB=LLN<A:LMA>;EHH= L:EBO: LP>:M M>:KL OHFBM L>F>G:G=LMHHEL

(82) %FIKHI>KA:G=EBG@LH? MA> I:MB>GML HK ;NKB:E IK:<MBL>L :K> <HGLB=>K>= MH ;> MA> F:BG <:NL> H? OBKNL MK:GLFBLLBHG

(83) %GBMB:EER BMP:LMAHN@AMMA:M!+2<HNE=GHM;>MK:GLFBMM>=HNMLB=>H?MA>LRFIMHF:MB<IA:L>

(84) $HP>O>K MA>OBKNLP:L?HNG=MH;>:;E>MHI>KLBLM?HK:EHG@>KMBF>BGLHF>BFFNG> IKBOBE>@>= LBM>L?HEEHPBG@<E>:K:G<>?KHFMA>;EHH=LMK>:F78

(85) 2BK:E.*A:L;>>G=>M><M>=BG;K>:LM FBED O:@BG:EL><K>MBHGL H<NE:K:JN>HNLANFHKL:G=L>F>GL>O>K:EP>>DLMHL>O>K:EFHGMAL :?M>KK>FBLLBHG

(86) %GMABLK>@:K= BG?><MBHNL!+2P:L:ELHBLHE:M>=?KHFL>F>GFHK>MA:GMAK>> FHGMAL:?M>KOBK:E<E>:K:G<>?KHF;EHH= :G=L>QN:EMK:GLFBLLBHGH?!+2A:L;>>GK>IHKM>= :G=EBGD>=MHMA>LM:KMH?G>PMK:GLFBLLBHG<A:BGLL>O>K:E=:RL:?M>K!;HE: ?K>>=><E:K:MBHGBG MA><HNGMKB>L7f8

(87) 0A> IK>L>G<> H? MA> OBKNL BG FNEMBIE> ;H=BER ?ENB=L PHNE= LN@@>LM MA:M MK:GLFBLLBHG MAKHN@A ?HFBM>LBL:ELH:D>RBG!+2MK:GLFBLLBHG:G=PHNE=IE:<>MA>A:G=EBG@H?MA>I:MB>GMLHK MA><:=:O>KL:MMA><>GMK>H?MA>MK:GLFBLLBHG>O>GM:G=IKHI:@:MBHGH?MA>HNM;K>:D

(88) %GMABL K>@:K= :LMN=RPA>K>!+2P:LLIBD>==BK><MERBGMHANF:G;EHH= A:LLAHPGMA:MMA>OBKNL P:LLM:;E>BG;HMA=KR:G=EBJNB=;EHH=:G=MA:MEBO>OBKNL<HNE=;>K>MKB>O>=NIMH=:RL:?M>K LIBDBG@78

(89) /BFBE:KER ((!LMN=B>LLAHP>=MA:M!+2<HNE=;>=>M><M>=:G=K>MKB>O>=?KHF MA><HKIL>LH?=>:=FHGD>RLL>O>K:E=:RL:?M>KMA>BK=>:MA78

(90) 0A> IHLLB;BEBMR H? :BK;HKG> HK :>KHLHE MK:GLFBLLBHG =NKBG@ ?BEHOBKNL HNM;K>:DL BL NG<E>:K

(91) "BEHOBKNLHNM;K>:DL:K>NLN:EERK>LMKB<M>=BGM>KFH?LBS>:G=MA>OBKNL>L=HGHMLIK>:=K:IB=ER BGMH MA> ANF:G IHINE:MBHG :L BM <:G ;> H;L>KO>= PBMA LBFBE:K OBKNL>L LN<A :L %G?EN>GS: HK )>:LE>LOBKNL>L LN@@>LMBG@MA:M?BEHOBKNL>L:K>GHM:BK;HKG>OBKNL>L

(92) !QI>KBF>GM:EERBG?><M>= IB@L PBMA : .!/02 IB@ BLHE:M> P>K> LAHPG MH LA>= MA> OBKNL :LRFIMHF:MB<:EER ?KHF MA> G:LHIA:KRGQ :G= !+2 A:L ;>>G ?HNG= BG ANF:G :EO>HEB

(93) 0AHL> =:M: MA>K>?HK> K:BL> MA>. . . ".,KHIHKMBHGH?<:L>LPBMABG:=>LB@G:M>=IHINE:MBHGPAH=B>:L:K>LNEMH?:GBG?><MBHG78

(94) "HFBM>L%G:GBF:M>H;C><MHKLN;LM:G<><:I:;E>MH<:KKRBG?><MBHNLHK@:GBLF:G=MHMK:GL?>KBM?KHF HG>BG=BOB=N:EMH:GHMA>K

(95) BK;HKG> MK:GLFBLLBHG L =>?BG>= ;R 78 j0K:GLFBLLBHG K>LNEMBG@ ?KHF MA> BGA:E:MBHG H? LF:EE K>LIBK:;E>BG?><MBHNLI:KMB<E>LbFBGLBS>=BLI>KL>=HO>KEHG@=BLM:G<>L;R:BK<NKK>GML

(96) . . gm.

(97) IHLLB;BEBMR MA:M =KHIE>M MK:GLFBLLBHG BL IHLLB;E> :G= A:L ;>>G LNLI><M>= MH >QIE:BG LHF> <A:BGH?MK:GLFBLLBHGLPA>GGH=BK><M<HGM:<MPBMA:GBG?><M>=I>KLHGP:LK>IHKM>=7 8

(98) "BG:EER PABE>*$,P>K>LN<<>LL?NEERBG?><M>=?HEEHPBG@!+2:>KHLHEBS:MBHGBG:<HGMKHEE>= >GOBKHGF>GM BMBLGHMDGHPGPA>MA>KMA>OBKNL<HNE=;>MK:GLFBMM>=MABLP:RBG:G:MNK:EL>MMBG@

(99) %G=>>= MA>OBKNLP:LLAHPGMH;>>QMK>F>ERNGLM:;E>?HEEHPBG@:>KHLHEBS:MBHG:G=:LLN<A >O>GMAHN@ABMBLGHMIHLLB;E>MH<HFIE>M>ERKNE>HNM:>KHLHEL:L:MK:GLFBLLBHGKHNM> BMPHNE= ;>:O>KRNGEBD>ER>O>GM >LI><B:EERBGMA>=B??>K>GMMKHIB<:EHK:KB=>GOBKHGF>GMLH?MA>?KB<:G <HGMBG>GM7 8

(100) />O>K:E KBLD ?:<MHKL ?HK ?BEHOBKNL MK:GLFBLLBHG A:O> ;>>G B=>GMB?B>= ;:L>= HG MA> IK>OBHNL HNM;K>:DL:G=:K>:LLH<B:M>=MH:GBG<K>:L>=KBLD7 8

(101) L>QI><M>= MA><A:G<>LH?;>BG@ BG?><M>=:K>FN<AFHK>BFIHKM:GMPA>G;>BG@BG=BK><M<HGM:<MPBMA:GBG?><M>=BG=BOB=N:E:M AHF> HK :M MA> AHLIBM:E HK PBMA BG?><M>= ?ENB=L

(102) L LN<A MA> NL> H? BG:IIKHIKB:M> I>KLHG:E IKHM><MBO>>JNBIF>GMHKIHHKF>=B<:EIK:<MBL>LLN<A:L>QIHLNK>MHNGLM>KBEBS>= <HGM:FBG:M>= G>>=E>LA:O>:ELHIE:R>=:GBFIHKM:GMKHE>BGLIK>:=BG@MA>=BL>:L>BGLHF>H?MA>!+2:G= ).2 HNM;K>:DL

(103) 0:DBG@ I:KM BG ?NG>K:E KBMN:EL IK>I:KBG@ :G= MHN<ABG@ MA> <:=:O>K :ELH LB@GB?B<:GMERBG<K>:L>LMA><A:G<>H?@>MMBG@BG?><M>=

(104) %GM>K>LMBG@ER <ABE=K>GMHR>:KLHE= H?:@>L>>FMH;>K>E:MBO>ERLI:K>=?KHF<HGMK:<MBG@MA>=BL>:L>:G=K><>GM=:M:LN@@>LMMA:M MA>R:K>:<MN:EERE>LLLNL<>IMB;E>MH?BEHOBKNLBG?><MBHGL7 8

(105) 0A>K>?HK> @>G>MB<?:<MHKL<HNE= IE:R : KHE> BG ?BEHOBKNL LNL<>IMB;BEBMR :L BM A:L ;>>G LAHPG ?HK LHF> /BG@E> *N<E>HMB=> ,HERFHKIABLFL/*,BGMA>*B>F:GG ,B<D*,@>G>>G<H=BG@:<>EENE:K>G=HLHF:E IKHM>BGPAB<ABLMA>G><>LL:KRK><>IMHK?HK!+2>GMKR7 8L>>;>EHPj"NEE E>G@MA#, HKNLBG@:@>G>MB<:EER=BO>KL>I:G>EH?K><HF;BG:GMBG;K>=FB<>78

(106) . 0A>K> BL GH <HGL>GLNL =>?BGBMBHG ?HK PA:M <E:LLB?B>L : LI>L :L : G:MNK:E K>L>KOHBK ?HK : LI><B?B< I:MAH@>G ;NM BM <:G ;> =>?BG>= :L jHG> HK FHK> >IB=>FBHEH@B<:EER <HGG><M>= IHINE:MBHGLHK>GOBKHGF>GMLBGPAB<A:I:MAH@>G<:G;>I>KF:G>GMERF:BGM:BG>=:G=?KHF PAB<A BG?><MBHG BL MK:GLFBMM>= MH MA> =>?BG>= M:K@>M IHINE:MBHGk 78

(107) GHMA>K <HFFHGER :<<>IM>==>?BGBMBHGBLMA:MG:MNK:EK>L>KOHBKL:K>:;E>MHK>IEB<:M>MA>OBKNL;NMLAHPEBMME>HKGH LB@GH?=BL>:L><HFI:K>=MH:G:<<B=>GM:E :FIEB?RBG@AHLM

(108) ==BMBHG:EER G:MNK:EAHLMLA:O>: AB@A>KL>KHIK>O:E>G<>MA:G:<MBO>BG?><MBHGIK>O:E>G<>78

(109) >LIBM>BGM>GLBO>>??HKMLMHB=>GMB?RK>L>KOHBKLI>L?HK?BEHOBKNL>LHO>KMA>I:LMR>:KL BMBL LMBEENG<>KM:BGPA:MMA>G:MNK:EK>L>KOHBKL?HK>;HE:OBKNL>L:<MN:EER:K>

(110) *NF>KHNLLMN=B>LA:O> MKB>=MHB=>GMB?ROBK:EAHLML>BMA>K;RL:FIEBG@:GBF:EL?HK:GMB;H=B>L:G= HK.*=>M><MBHGHK ?HKOBK:EBLHE:MBHGHKMAKHN@A>QI>KBF>GM:EERBG?><MBHGBGE:;HK:MHKRL>MMBG@L7 8

(111) M?BKLM BM P:L ARIHMA>LBS>= MA:M LBFBE:KER MH (:LL: OBKNL LF:EE KH=>GML <HNE= MK:GLFBM ?BEHOBKNL :G= >OB=>G<> H? !+2 .* P:L >O>G ?HNG= BG HG> >:KER LMN=R ;NM LBFBE:K K>LNEML P>K> G>O>K . KHIE>M MK:GLFBLLBHG L =>?BG>= ;R 78 j"HKF H? =BK><M <HGM:<M MK:GLFBLLBHG BG PAB<A K>LIBK:MHKR =KHIE>MLbFBGLBS><:KKRBG@:GBG?><MBHNLI:MAH@>GMK:GLFBMBG?><MBHGPA>GMK:O>EBG@LAHKM=BLM:G<>L =BK><MER ?KHF MA> K>LIBK:MHKR MK:<M H? MA> BG?><MBHNL BG=BOB=N:E MH LNL<>IMB;E> FN<HL:E LNK?:<>L H? MA> K><BIB>GM

(112) k . . gn.

(113) H;M:BG>=:@:BG7 8

(114) !QI>KBF>GM:EBG?><MBHGH?=B??>K>GMKH=>GML ?ERBG@F:FF:EL:G=>O>G IE:GMLI>K?HKF>=;R/P:G>IH>E.&LAHP>=MA:MHGER;:ML;HMA?KN@BOHKHNL:G= BGL><MBOHKHNLP>K>:;E>MHK>IEB<:M>MA>OBKNLPBMAGHLB@GH?=BL>:L> IHBGMBG@MH;:ML:L: IHM>GMB:E<:G=B=:M>AHLM78

(115) :ML:K>MA>L><HG=FHLM=BO>KL>F:FF:EB:GHK=>KPBMAHO>KLI>L:G=:K>IK>L>GM PHKE=PB=>

(116) 0A>RA:O>;>>GB=>GMB?B>=:LMA>G:MNK:EK>L>KOHBK?HKGNF>KHNLHMA>KK> >F>K@BG@ OBKNL>LLN<A:L<HKHG:OBKNL>L I:K:FRQHOBKNL>LHK%G?EN>GS:OBKNL>L

(117) 0A>BKEHG@EB?>LI:GL MA> NL> H? MHKIHK :G= ?EB@AM MA>BK =B>M :L P>EE :L MA> ?:<M MA:M MA>K> :K> EBOBG@ BG E:K@> <HFFNGBMB>L PBMALHF>KHHLMLMA:M<:GAHNL>FHK>MA:G:MAHNL:G=BG=BOB=N:ELH?MA>L:F> HK=B??>K>GMLI>L :K>MAHN@AMMH?:<BEBM:M>OBKNLF:BGM>G:G<>:G=MK:GLFBLLBHG7 8

(118) 0A> BLHE:MBHG BG H? ).2 ?KHF )"&'% :G= MA> =BL<HO>KR H? ((+2 BG %$$%;:MLBG=B??>K>GMEH<:MBHGLL>O>K:ER>:KL:I:KM BLLN@@>LMBO>?HK;:ML;>BG@:G:MNK:E K>L>KOHBK ?HK ?BEHOBKNL>L 7 8

(119) GHMA>K IB><> H? >OB=>G<> BL MA> B=>GMB?B<:MBHG H? G>P .* L>JN>G<>L?KHFNGB=>GMB?B>= IHM>GMB:E?BEHOBKNLLI>LBGABG:BG% '& %" :G=LII;:ML7 8

(120) 0A>K>LNEML?KHFMABLLMN=RLN@@>LMMA:M:ME>:LMIHM>GMB:EG>PLI>L HK@>G>K::K>IK>L>GMBG):BGE:G=ABG:

(121) %GM>K>LMBG@ER PABE>AB@AGNF;>KLH?@>GHFB<<HIB>L <HNE=;>=>M><M>=BGLHF>H?MA>BG?><M>=MBLLN>L :G=MA:MHG>;:MP:L>O>GBG?><M>=PBMA?HNK =B??>K>GM ?BEHOBKNL>L ;:ML P>K> :<<HK=BG@ MH MA> :NMAHKL L>>FBG@ER A>:EMAR

(122) !QI>KBF>GM:EER BGH<NE:MBHGL H? :KMAKHIH= ?K>> )"&'% PBMA ).2 LAHP MA:M ;:ML :K> I>KFBLLBO> MH OBKNL K>IEB<:MBHG PBMA GH :II:K>GM LB@G H? =BL>:L>L :G= :K> :;E> MH =>O>EHI : EHG@ E:LMBG@ IKHM><MBO> BFFNGBMR :@:BGLM MA> OBKNL ?HEEHPBG@ MA> K>LHENMBHG H? MA> BG?><MBHG MA:M IKHM><ML :GBF:EL?KHFK>BG?><MBHG :ME>:LM NIMHMPHFHGMAL?HEEHPBG@MA>BGBMB:E<A:EE>G@>

(123) +K:E:G= K><M:ELA>==BG@H?BG?><MBHNLOBKNL :LP>EE:LMA>IK>L>G<>H?MA>OBKNLBGMA>NKBG>A:O>:ELH ;>>G<HG?BKF>= LN@@>LMBG@MA:M=BK><MHKBG=BK><M<HGM:<MPBMABG?><MBHNL;H=BER?ENB=LBLEBD>ER K>LIHGLB;E>?HKMA>AHKBSHGM:EMK:GLFBLLBHGH?MA>OBKNL;>MP>>G;:ML:G=IKH;:;ER;>MP>>G HMA>KLI>L BG<EN=BG@ANF:GL7f8

(124) 0ANL :ME>:LMBGMA><:L>H?).2 )"&'% ?NE?BE:EE<KBM>KB:MH;><:EE>=:G:MNK:EK>L>KOHBK

(125) /H ?:K !;HE:OBKNL A:L G>O>K ;>>G BLHE:M>= =BK><MER ?KHF :GBF:E MBLLN>L :G= MA>K>?HK> MA> G:MNK:E K>L>KOHBK ?HK !;HE:OBKNL BL LMBEE NGDGHPG

(126) />O>K:E ;:M LI>L :K> LNLI><M>= MH ;> IHM>GMB:E AHLML ?HK !;HE:OBKNL BG<EN=BG@ (' )"&'% '% HK '&&!$ $ #'& :G= ! %&$!%'% ;NM MAHL> :LLNFIMBHGL :K> ;:L>= HGER HG :GMB;H=B>LHKI:KMB:E.*L>JN>G<>=>M><MBHG0:;E>78

(127) ((!:G= (&$!LMN=B>LA:O> A>EI>=MHLA>=EB@AMBGMHIHM>GMB:EK>L>KOHBKAHLML?HK!+2

(128) %G=>>= BMA:L;>>GLAHPGMA:M (' DB=G>R ?B;KH;E:LM <>EE EBG>L P>K> =K:LMB<:EER E>LL LNL<>IMB;E> MH !+2 BG?><MBHG <HFI:K>= MH ?B;KH;E:LML =>KBO>= ?KHF )"&'% :G= '&&!$ <>EE EBG>L =N> MH : P>:DBGM>K:<MBHG;>MP>>G!+2@ER<HIKHM>BG#, MA:M=KBO>L>GMKRBGMH<>EEL:G= (' *,L>>;>EHP,:K:@K:IAj"NEE E>G@MA#, k

(129) %GM>K>LMBG@ER MABLEBFBM>=;BG=BG@A:L;>>G F:II>=MH:LBG@E>:FBGH:<B=BG*,:G=<HNE=;>IHM>GMB:EERNL>=MHIK>=B<MPA>MA>K:;:M LI>LBL:<:G=B=:M>AHLM?HK!+278

(130) 3ABE> (&$!K>LNEMLLNIIHKMMA>ARIHMA>LBLMA:M )"&'%BL:IHLLB;E>AHLM?HK!+2 :L)"&'% =>KBO>=<>EEEBG>LK>IEB<:M>MA> OBKNL:L>??BGMER:L).2 :G ((!>QI>KBF>GMLAHP>=MA:M?HEEHPBG@!+2BGH<NE:MBHG )"&'%;:ML=HGHM;><HF>OBK>FB<BGMA>M>LM>=<HG=BMBHGL:LBG@E>KHNM>H?BGC><MBHG :G=:LBG@E>=HL>H?OBKNLPBMA:EBFBM>=GNF;>KH?:GBF:ELM>LM>=78

(131) HGL>JN>GMER (&$! >QI>KBF>GML NLBG@ ;:M <>EE EBG>L =>KBO>= ?KHF MBLLN>L MA:M :K> GHM MA> IKBF:KR M:K@>ML H? ?BEHOBKNL>L FHGHGN<E>:K IA:@H<RMB< EBG>:@> <>EEL A>I:MH<RM>L LIE>GH<RM>L G>>= MH ;>. . go.

(132) BGM>KIK>M>=<:NMBHNLER

(133) "NKMA>KFHK> MA> (&$!:G= ((!>QI>KBF>GMLP>K>I>K?HKF>=NLBG@ OBKNL>LMA:MP>K>BLHE:M>=?KHFANF:GL:G=*$,:G=HG><:GGHM>Q<EN=>MA:MMA>L>OBKNL>L P>K> FHK> :=:IM>= MH ANF:G *$, MA:G ;:ML

(134) .>LNEML ?KHF &HG>L )! & :ELH >G<HNK:@>MA>B=>:MA:M;:MLI>L:K>:=:IM>=MHLNIIHKMMA>K>IEB<:MBHGH?HG>HK<EHL>ER K>E:M>=?BEHOBKNL>L:G=MA:MMA>MKHIBLFH??BEHOBKNLBG;:MLBLEBFBM>=;R=B??>K>GM?:<MHKL

(135) :K>?NE :G:ERLBLH?MA>IAREH@>G>MB<:G:ERLBLK>LNEMLH;M:BG>=;R5:G@4(&:ELH?:OHNKL MABLARIHMA>LBL:LMA>?BEHOBKNL>L=BL<HO>K>=BG.HNL>MMNLLI>L:K>:EE<ENLM>K>=PBMA).2 7 8

(136) %G&NER :LBQMA!;HE:OBKNLLI>L HF;:EBOBKNLP:L=BL<HO>K>=BGMPH=B??>K>GM ;:MLI>L"''%:G= ! )'$'%K>BG?HK<BG@:@:BGMA>B=>:H?;:ML;>BG@MA>G:MNK:E K>L>KOHBKH??BEHOBKNL>L78

(137) .

(138) >5

(139)

(140)

(141) . %G:==BMBHGMH;:ML:LG:MNK:EK>L>KOHBKL?HK?BEHOBKNL>L L>O>K:EHMA>KLI>LP>K>B=>GMB?B>=:L :FIEB?RBG@ AHLML LN<A :L *$, =NBD>KL :G= LPBG> "B@

(142)

(143) :K<:L>L H? @HKBEE:L :G= <ABFI:GS>>L :LP>EE:L:GM>EHI>L IHLBMBO>?HKMA>OBKNLA:L;>>G?HNG=:ML>O>K:EH<<:LBHGL

(144) %G=>>= HNM;K>:DL BG PBE= :GBF:EL A:O> <HFFHGER IK><>=>= HNM;K>:DL BG MA> ANF:G IHINE:MBHG:G=PHNE=H?M>G:II>:KMH;>MA><:NL>H?MA>LIBEEHO>KBGMHANF:GLHMR7 8

(145) %MA:L;>>G>LMBF:M>=MA:MMA>!+2HNM;K>:DL;>MP>>G:G=BG@K>:M:I>LA:LE>= MH:G:E:KFBG@=><EBG>H?FHK>MA:GH?MA>IHINE:MBHG78

(146) %GLHF>:K>:L BMBL;>EB>O>= MA:M!+2BLK>LIHGLB;E>?HKMA>=BL:II>:K:G<>H?:ME>:LMH?MA>=NBD>KL:G=H?MA> <ABFI:GS>>L78

(147) #KHNI MH @KHNIMK:GLFBLLBHGH?MA>OBKNL;>MP>>G@HKBEE:L:II>:KLMH;> ?:<BEBM:M>=;RMA>BKLH<B:EA:;BMN=> >LI><B:EERMA>BKA:;BMLH?BGLI><MBG@<:K<:L>LH?HMA>K=>:= @HKBEE:L ?KHF HNMLB=> H? HG>kL @KHNI HK ?>>=BG@ HG ?KNBM ?KHF MA> L:F> MK>> PAB<A <HNE= ;> <HGM:FBG:M>=PBMABG?><M>=;H=BER?ENB=L?KHF;:ML78

(148) /BFBE:KER .!/02P:LBLHE:M>=BGBMB:EER hf.

(149) ?KHF <RGHFHE@NL FHGD>RL BFIHKM>= ?KHF 0A> ,ABEBIIBG>L 78

(150) "HK .!/02 PABE> GH !;HE:OBKNL EBD>=BL>:L>P:LH;L>KO>=BGMA>:=NEMANF:GLMA:MP>K>BG?><M>=MA>OBKNLBLMANL <HGLB=>K>=GHG I:MAH@>GB<BGANF:GL BMBLAB@AERE>MA:EBGFHGD>RL K>BG?HK<BG@MA>B=>:MA:M *$,:K>AB@AERLNL<>IMB;E>MH?BEHOBKNLBG?><MBHG

(151) ==BMBHG:EER .!/02A:L;>>GBLHE:M>=?KHF IB@L BG 0A> ,ABEBIIBG>L :G= : =BK><M <HGM:<M ;>MP>>G IB@L :G= BGL><MBOHKHNL ;:ML %$$%MA:MP>K>?HNG=IHLBMBO>;RJ,.:LL:RLA:L;>>GLN@@>LM>=MH;>MA><:NL>H? MA>IB@LkBGBMB:EBG?><MBHG7 8

(152) . :L>=HGMA>L>=B??>K>GMLMN=B>L ?BEHOBKNL>L:II>:KMANLMHA:O>:PB=>MKHIBLF:G=<:GBG?><M FNEMBIE> AHLML PBMA LHF> MA:M <:G LAHP GH LB@G H? =BL>:L>

(153) HGLB=>KBG@ MA> BFIHKM:GM ><HGHFB<O:EN>H?MA>B=>GMB?B>=:GBF:ELIB@?:KFBG@ ;NLAF>:M?HK;:ML:G=*$, :KHNMBG> :GBF:EL:FIEBG@H?MAHL>AHLML?HK:GMB;H=B>LHK.*=>M><MBHG<HNE=A>EIMHIK>O>GMLIK>:=BG@ H?MA>OBKNLBGMHMA>ANF:GIHINE:MBHG

(154) . . ?5

(155) + %"%! ".+)Zhol[.!,.!/!*0%*#0$!$5,+0$!/%/! !4%/0%*#.!(0%+*/$%,0+((+3!%0$!.)%*0!**!+""%(+2%.1/%*+*! +./!2!.(0/,!%!/X!/!.2+%. 5*)%/%*(1!YJ* 0$!%./,%((+2!./%*% !*0(*%)($+/0/X/3%*!J 1%'!./* #.!0,!/J* $1)*/K,%((+2!. 5*)%/J%*.! YM *0!.N$1)*0.*/)%//%+*%/(/+.!,.!/!*0! X%*5!((+3YM. hg.

(156) LJ . . "BEHOBKNL>LOBKBHGL:K>?BE:F>GMHNL PAB<AF:D>MA>FMA>HGER<NKK>GMERDGHPG:GBF:EOBKNL>L PBMA : ?BE:F>GMHNL LMKN<MNK>

(157) 3ABE> ?BEHOBKNLk =B:F>M>KL :K> H? :;HNM GF :G= :K> <HGLBLM>GM;>MP>>GMA>=B??>K>GM?BEHOBKNL@>G>K: ).2OBKBHGLE>G@MA:II>:KLMH;>LF:EE>K MA:G!+2OBKBHGL PBMA:LBS>H?:;HNMGF:G=GFK>LI><MBO>ER

(158) !E><MKHGFB<KHL<HIR :G:ERLBLLAHP>=MA:MMA>OBKBHGL:K>?E>QB;E>:G=BM<:G?HKF1HK LA:I>"B@

(159)

(160) 0ABL?E>QB;BEBMR BLLN@@>LM>=MH;>BFIHKM:GMMHIKHM><MMA>LBG@E> LMK:G=>=G>@:MBO> L>GL>.* LL.* @>GHF>?KHF;K>:DBG@MHEBFBMMA>IKH=N<MBHGH?GHG BG?><MBHNLOBK:EI:KMB<E>L7f8

(161) . . FFE'&. HKE'&. @5

(162)

(163) 0%*! ".+)Zki[M!#0%2!(5+*0./0! 2%.%+*/XYJ%((1/0.0%*#0$!"%()*!0+1/X"1((..+3/Y* lN/$,! "+.)/ X..+3$! /Y +" 0$! 2%.( ,.0%(!/M 2%.%+* .+//N/!0%+* XY /$+3%*# 0$! jkNkf*) *1(!+,/% X..+3$! /Y* 0$!2%.($+/0N !.%2! )!).*! !+.0! 5#(5+,.+0!%*/,%'!/X/,!.$! /YM. !;HE:OBKNLA:L:D;@>GHF>MA:MLM:KML;R:kE>:=>KGHG <H=BG@K>@BHG ?HEEHP>=;RL>O>G @>G>L:KK:G@>=BGM:G=>F>G<H=BG@L>O>GLMKN<MNK:EIKHM>BGL0A>GN<E>HIKHM>BG*, 2, 2, 2, MA>@ER<HIKHM>BG#, :G=MA>.* =>I>G=:GM.* IHERF>K:L>IHERF>K:L>( :G= MPH L><K>M>= GHG LMKN<MNK:E IKHM>BGL MA> LHEN;E> #, L#, :G= MA> LNI>K LF:EE #, LL#,

(164) 0A>@>GHF>BLM>KFBG:M>=;R:kMK:BE>KGHG <H=BG@K>@BHG"B@

(165)

(166) MMA>>Q<>IMBHG H?MA>#,@>G>PAB<A@BO>LKBL>MHMAK>>=B??>K>GMIKHM>BGLMAKHN@AMK:GL<KBIMBHG:E>=BMBG@ :EE HMA>K!+2@>G>LIKH=N<>:LBG@E>OBK:EIKHM>BG78

(167) . hh.

(168) #-#'!,#-.

(169) +=<> H:. . HJ. L&,. IE. .*$(. . L&,. +#%+=R> HE. .*$(. GI. HKK&,. J:.

(170) . K&,9.*$(. MNO&,. A5 + %"%! ".+)Zlf[M$!)0%(.!,.!/!*00%+*+"#!*+)!+.#*%60%+*M00$!!4!,0%+*+"0$! #!*!J0$!#!*!/ .! .3*0+/(!M,!*.! %*#".)!.!,%*0! %*#.!5* 0$!1*0.*/(0! .!#%+*/%*3$%0!M$%0!0.%*#(!/.! /$+3%*##!*!/0.0* ('./J#!*!!* /M$!(!*#0$* 0$!*01.!* /%6!+"0$!%*0!.#!*%.!#%+*/X*+00+/(!Y .!%* %0! J/3!((/0$!,+/%0%+*+"! %0%*#/%0!M. . 0A> k E>:=>K BL : GN<E>HMB=>L K>@BHG ?HKF>= H? : <BL :<MBG@ IKHFHM>K PAB<A =KBO>L MA> ?HKF:MBHGH?:<HFIE>F>GM:KR:GMB@>GHF>MA:MBLNL>=:L:M>FIE:M>?HKMA>K>IEB<:MBHGH?MA> @>GHF> "B@

(171)

(172) 0A> GN<E>HMB=> <HFIE>F>GM:KR k MK:BE>K >G= L>KO>L :L : LB@GB?B<:GMER LMKHG@>KIKHFHM>KMA:GMA>kE>:=>KIKHFHM>K:G=:EEHPL?HKBGM>GL>K>IEB<:MBHGH?MA>OBK:E @>GHF>

(173) ,K>=B<MBHGLH?L><HG=:KRLMKN<MNK>LN@@>LMMA:M;HMAMA>E>:=>K:G=MK:BE>KK>@BHGL <:GBGM>K:<MMH@>MA>KMH?HKF:I:GA:G=E>LMKN<MNK> R>M BMBLGHM<E>:KB?MA>RBG=>>=?HKFLN<A LMKN<MNK>=NKBG@MA>BG?><MBHG