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Structural and functional study of the interaction between CXCL12 chemokine and its receptors : CXCR4 and ACKR3/CXCR7

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Figure

Fig 1. Schematic view of CKs subfamilies based on primary structure
Fig  3. A typical CK monomeric unit is shown at the top (CCL20; PDB ID 2JYO). The CC- CC-type  dimer  is  formed  from  contacts  between  the  N-terminal  fragments  of  each  subunit  to  create  an  elongated  shape  (CCL2  homodimer;  PDB  ID  1DOM)
Fig 6. Two-steps mechanism for CK-CKR interaction (Crump, Gong et al. 1997).
Fig 7. Molecular models and experimental designs of CXCR4:CXCL12 interaction. (A) NMR  structure of CXCL12 (skin mesh) in complex with the N terminus of CXCR4 (residues M1–
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