Impact des effets indésirables médicamenteux en infectiologie : comparaison anti-infectieux et non anti-infectieux
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(28) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ ŽLJĞŶ Wƌ͘YhWĂƚƌŝĐŬ sŝĐĞͲĚŽLJĞŶƐ WĠĚĂŐŽŐŝĞ ZĞĐŚĞƌĐŚĞ ƚƵĚŝĂŶƚƐ ŚĂƌŐĠĚĞŵŝƐƐŝŽŶƉƌŽũĞƚĂŵƉƵƐ. Wƌ͘WYh/^WŚŝůŝƉƉĞ. ŽŶƐĞƌǀĂƚĞƵƌĚĞůĂďŝďůŝŽƚŚğƋƵĞ. DŵĞD^>>ĂŶŝğůĞ. ŝƌĞĐƚƌŝĐĞĂĚŵŝŶŝƐƚƌĂƚŝǀĞĚĞƐƐĞƌǀŝĐĞƐ. DŵĞ>>/ƐĂďĞůůĞ. ŽLJĞŶƐ,ŽŶŽƌĂŝƌĞƐ. ŵăũϯϭͬϬϴͬϮϬϭϴ. Wƌ͘>hEE/sĠƌŽŶŝƋƵĞ Wƌ>>DKE/ũĞĂŶ D͘:KhEZŽďŝŶ. D͘zZhEŽģů D͘ZDW>WĂƚƌŝĐŬ D͘E,/DK>ĂŶŝĞů. ϭ.
(29) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ WZK&^^hZ^>^^yWd/KEE>> D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ DŵĞ D͘ D͘ D͘ D͘ D͘ D͘ DŵĞ D͘ D͘ D͘ D͘ D͘ D͘ D͘. ŵăũϯϭͬϬϴͬϮϬϭϴ. D/>:ĞĂŶ YhWĂƚƌŝĐŬ ZEZ/E'ŝůůĞƐ K/>hWĂƐĐĂů ZKhZd:ĂĐƋƵĞƐ ^Eh>dsŝŶĐĞŶƚ &E/,>WĂƚƌŝĐŬ &h/d:ĞĂŶͲ'ĂďƌŝĞů '/>^KEƌŝĐ 'h'E,/D:ĞĂŶ ,^^E<,K:ZĞĚĂ ,hdZEyĂǀŝĞƌ ,K&DEWĂƵů /,/ĂƌŽůĞ >KhZ:ĞĂŶͲWŚŝůŝƉƉĞ >&d,Z/Kd/^'ĞŽŐƌĞƐ DZYhddŚĂƌůĞƐͲ,ƵŐŽ DZdzWŝĞƌƌĞ D/,/>^:ĞĂŶͲ&ƌĂŶĕŽŝƐ DKhZKhy:ĠƌƀŵĞ WYh/^sĠƌŽŶŝƋƵĞ WYh/^WŚŝůŝƉƉĞ YhdZ,KDD'ĠƌĂůĚ ZhKh>^Ͳ/DDĂƌĐ ZKZdWŚŝůŝƉƉĞ ^Ed/E/:ŽƐĞƉŚ d,z^^ŶƚŽŝŶĞ dZEůďĞƌƚ. hƌŽůŽŐŝĞ;ϱϮ͘ϬϰͿ ŶĂƚŽŵŝĞͲŚŝƌƵƌŐŝĞ'ĠŶĠƌĂůĞ;ϰϮ͘ϬϭͿ ZĠĂŶŝŵĂƚŝŽŶDĠĚŝĐĂůĞ;ϰϴ͘ϬϮͿ ŚŝƌƵƌŐŝĞKƌƚŚŽƉĠĚŝƋƵĞĞƚdƌĂƵŵĂƚŽůŽŐŝƋƵĞ;ϱϬ͘ϬϮͿ ŝŽƉŚLJƐŝƋƵĞĞƚDĠĚĞĐŝŶĞEƵĐůĠĂŝƌĞ;ϰϯ͘ϬϭͿ EĠƉŚƌŽůŽŐŝĞ;ϱϮͲϬϯͿ ŝŽůŽŐŝĞĚƵĠǀĞůŽƉƉĞŵĞŶƚĞƚĚĞůĂZĞƉƌŽĚƵĐƚŝŽŶ;ϱϰ͘ϬϱͿ DĠĚĞĐŝŶĞ/ŶƚĞƌŶĞ;ϱϯ͘ϬϭͿ ŝŽůŽŐŝĞĞůůƵůĂŝƌĞ;ϰϰ͘ϬϯͿ ŚŝƌƵƌŐŝĞŝŐĞƐƚŝǀĞ;ϱϮ͘ϬϮͿ ŚŝƌƵƌŐŝĞsĂƐĐƵůĂŝƌĞ;ϱϭ͘ϬϰͿ EƵƚƌŝƚŝŽŶ;ϰϰ͘ϬϰͿ ŶĂƚŽŵŝĞĞƚLJƚŽůŽŐŝĞWĂƚŚŽůŽŐŝƋƵĞƐ;ϰϮ͘ϬϯͿ ŶĞƐƚŚĠƐŝŽůŽŐŝĞĞƚZĠĂŶŝŵĂƚŝŽŶŚŝƌƵƌŐŝĐĂůĞ;ϰϴ͘ϬϭͿ ĞƌŵĂƚŽͲsĠŶĠƌĠŽůŽŐŝĞ;ϱϬ͘ϬϯͿ ŚŝƌƵƌŐŝĞǀĂƐĐƵůĂŝƌĞ͖ŵĠĚĞĐŝŶĞǀĂƐĐƵůĂŝƌĞ;ϱϭ͘ϬϰͿ WŶĞƵŵŽůŽŐŝĞ;ϱϭ͘ϬϭͿ WĂƌĂƐŝƚŽůŽŐŝĞĞƚDLJĐŽůŽŐŝĞ;ϰϱ͘ϬϮͿ ŶĂƚŽŵŝĞĞƚLJƚŽůŽŐŝĞWĂƚŚŽůŽŐŝƋƵĞƐ;ϰϮ͘ϬϯͿ ŚŝƌƵƌŐŝĞdŚŽƌĂĐŝƋƵĞĞƚĂƌĚŝŽǀĂƐĐƵůĂŝƌĞ;ϱϭ͘ϬϯͿ 'ĠŶĠƚŝƋƵĞ;ϰϳ͘ϬϰͿ EĞƵƌŽĐŚŝƌƵƌŐŝĞ;ϰϵ͘ϬϮͿ DĠĚĞĐŝŶĞ>ĠŐĂůĞĞƚƌŽŝƚĚĞůĂ^ĂŶƚĠ;ϰϲ͘ϬϯͿ ŶĞƐƚŚĠƐŝĞĞƚZĠĂŶŝŵĂƚŝŽŶŚŝƌƵƌŐŝĐĂůĞ;ϰϴ͘ϬϭͿ WƐLJĐŚŝĂƚƌŝĞĚ͛ĚƵůƚĞƐ;ϰϵ͘ϬϯͿ K͘Z͘>͘;ϱϱ͘ϬϭͿ ĂŶĐĠƌŽůŽŐŝĞ͕ZĂĚŝŽƚŚĠƌĂƉŝĞ;ϰϳ͘ϬϮͿ ,ĠƉĂƚŽ'ĂƐƚƌŽͲĞŶƚĠƌŽůŽŐŝĞ;ϱϮ͘ϬϭͿ. Ϯ.
(30) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ WZK&^^hZ^WZD/Z>^^ DŵĞ D͘ D͘ DŵĞ D͘ DŵĞ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ D͘ DŵĞ D͘ D͘ D͘ D͘ D͘. ŵăũϯϭͬϬϴͬϮϬϭϴ. ^<EzͲ'/ddZ&ůŽƌĞŶĐĞ ZZE'ZŵŵĂŶƵĞů ZZƚŝĞŶŶĞ >EͲWhdKhZ&ůŽƌĞŶĐĞ KE'/EŶĚƌĠ Zh/>sĠƌŽŶŝƋƵĞ ^d/>>K>ĂƵƌĞŶƚ ,s>>/ZWĂƚƌŝĐŬ WZdd/&ĞƌŶĂŶĚ Z//DŝůŽƵͲĂŶŝĞů &ZZZ/ŵŝůĞ &ZZZK:ĞĂŶͲDĂƌĐ &KEd/EĞŶLJƐ '/>/EWŝĞƌƌĞ ,EEKhEͲ>s/:ĞĂŶͲDŝĐŚĞů >sZhd:ĂĐƋƵĞƐ >KE:KEDŝĐŚĞů DKhE/ZEŝĐŽůĂƐ WKsE/ĞƌŶĂƌĚ W/,dŚŝĞƌƌLJ WZ/ZŚƌŝƐƚŝĂŶ ZzEhŽŵŝŶŝƋƵĞ ZK^Ed,>ƌŝĐ ^,E/Z^ƚĠƉŚĂŶĞ ^d/E/WĂƐĐĂů d,KD^WŝĞƌƌĞ dZK:E/ŚƌŝƐƚŽƉŚĞ. WĠĚŽƉƐLJĐŚŝĂƚƌŝĞ;ϰϵ͘ϬϰͿ 'LJŶĠĐŽůŽŐŝĞKďƐƚĠƚƌŝƋƵĞ;ϱϰ͘ϬϯͿ WĠĚŝĂƚƌŝĞ;ϱϰ͘ϬϭͿ ĂŶĐĠƌŽůŽŐŝĞʹ'ĠŶĠƚŝƋƵĞ;ϰϳ͘ϬϮͿ 'LJŶĠĐŽůŽŐŝĞͲKďƐƚĠƚƌŝƋƵĞ;ϱϰ͘ϬϯͿ ZŚƵŵĂƚŽůŽŐŝĞ;ϱϬ͘ϬϭͿ K͘Z͘>͘;ϱϱ͘ϬϭͿ ZĂĚŝŽůŽŐŝĞĞƚ/ŵĂŐĞƌŝĞDĠĚŝĐĂůĞ;ϰϯ͘ϬϮͿ ŶĂƚŽŵŝĞͲŚŝƌƵƌŐŝĞKƌƚŚŽƉĠĚŝƋƵĞ;ϰϮ͘ϬϭͿ WŚĂƌŵĂĐŽůŽŐŝĞůŝŶŝƋƵĞ;ϰϴ͘ϬϯͿ ĂƌĚŝŽůŽŐŝĞ;ϱϭ͘ϬϮͿ ĂŶĐĠƌŽůŽŐŝĞ͖ZĂĚŝŽƚŚĠƌĂƉŝĞ;ϰϳ͘ϬϮͿ EĞƵƌŽĐŚŝƌƵƌŐŝĞ;ϰϵ͘ϬϮͿ ĂƌĚŝŽůŽŐŝĞ;ϱϭ͘ϬϮͿ ĂŶĐĠƌŽůŽŐŝĞ͖ZĂĚŝŽƚŚĠƌĂƉŝĞ;ϰϳ͘ϬϮͿ DĠĚĞĐŝŶĞĚΖƵƌŐĞŶĐĞ;ϰϴ͘ϬϱͿ EĞƵƌŽĐŚŝƌƵƌŐŝĞ;ϰϵ͘ϬϮͿ ĂŶĐĠƌŽůŽŐŝĞ͕ZĂĚŝŽƚŚĠƌĂƉŝĞ;ϰϳ͘ϬϮͿ ZĂĚŝŽůŽŐŝĞĞƚ/ŵĂŐĞƌŝĞDĠĚŝĐĂůĞ;ϰϯ͘ϬϮͿ 'ĂƐƚƌŽͲĞŶƚĠƌŽůŽŐŝĞ;ϱϮ͘ϬϭͿ ƉŝĚĠŵŝŽůŽŐŝĞ͕ĐŽŶŽŵŝĞĚĞůĂ^ĂŶƚĠĞƚWƌĠǀĞŶƚŝŽŶ;ϰϲ͘ϬϭͿ ,ĠŵĂƚŽůŽŐŝĞ;ϰϳ͘ϬϭͿ DĠĚĞĐŝŶĞ/ŶƚĞƌŶĞ;ϱϯ͘ϬϭͿ EƵƚƌŝƚŝŽŶ;ϰϰ͘ϬϰͿ ŝŽƐƚĂƚŝƐƚŝƋƵĞƐĞƚ/ŶĨŽƌŵĂƚŝƋƵĞDĠĚŝĐĂůĞ;ϰϲ͘ϬϰͿ EĞƵƌŽůŽŐŝĞ;ϰϵ͘ϬϭͿ ŚŝƌƵƌŐŝĞKƌƚŚŽƉĠĚŝƋƵĞĞƚdƌĂƵŵĂƚŽůŽŐŝƋƵĞ;ϱϬ͘ϬϮͿ. ϯ.
(31) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ WZK&^^hZ^hy/D>^^ DŵĞ D͘ D͘ DŵĞ DŵĞ D͘ D͘ D͘ D͘ D͘ DŵĞ D͘ D͘ D͘ D͘ DůůĞ DŵĞ D͘ D͘ D͘ D D͘ D͘ D͘ D͘ D͘ DŵĞ D͘. ŵăũϯϭͬϬϴͬϮϬϭϴ. >hEE/sĠƌŽŶŝƋƵĞ EdzZŽĚŽůƉŚĞ ,KZEWŚŝůŝƉƉĞ />>/&^ƚĠƉŚĂŶŝĞ EEtZd,^LJůǀŝĞ E/Z/ŵŵĂŶƵĞů EK/dDŝĐŚĞů KůĞdžĂŶĚƌĞ Zh:ĞĂŶ ,s>/ZEŝĐŽůĂƐ ,/Edd/'ŝƵůŝĂ >hhdŚŽŵĂƐ >>DKE/:ĞĂŶ >Kdd:ĠƌƀŵĞ &KhZE/Z:ĞĂŶͲWĂƵů '/KZEE'KsĂůĠƌŝĞ '/KsEE/E/Ͳ,D/>ŝƐĂ 'hZ/EKůŝǀŝĞƌ /EE>>/ŶƚŽŶŝŽ />/DĂƌŝƵƐ :EWd/^důŝdžğŶĞ W^^ZKEdŚŝĞƌƌLJ ZK'ZWŝĞƌƌĞͲDĂƌŝĞ ZK,Z>/,WŝĞƌƌĞ ZKhyŚƌŝƐƚŝĂŶ Zh/DzZĂLJŵŽŶĚ ^KE/^ĂďƌŝŶĂ ^Kh>:ĞĂŶͲ>ŽƵŝƐ. DĠĚĞĐŝŶĞ>ĠŐĂůĞĞƚƌŽŝƚĚĞůĂ^ĂŶƚĠ;ϰϲ͘ϬϯͿ 'ĂƐƚƌŽͲĞŶƚĠƌŽůŽŐŝĞ;ϱϮ͘ϬϭͿ LJƚŽůŽŐŝĞĞƚ,ŝƐƚŽůŽŐŝĞ;ϰϮ͘ϬϮͿ KƉŚƚĂůŵŽůŽŐŝĞ;ϱϱ͘ϬϮͿ 'ĠŶĠƚŝƋƵĞ;ϰϳ͘ϬϰͿ ŚŝƌƵƌŐŝĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϮͿ WƐLJĐŚŝĂƚƌŝĞ;ϰϵ͘ϬϯͿ KZ>ͲĂŶĐĠƌŽůŽŐŝĞ;ϰϳ͘ϬϮͿ ŚŝƌƵƌŐŝĞ/ŶĨĂŶƚŝůĞ;ϱϰͲϬϮͿ ŶĚŽĐƌŝŶŽůŽŐŝĞ͕ŝĂďğƚĞĞƚDĂůĂĚŝĞƐDĠƚĂďŽůŝƋƵĞƐ;ϱϰ͘ϬϰͿ ŝŽĐŚŝŵŝĞͲŝŽůŽŐŝĞDŽůĠĐƵůĂŝƌĞ;ϰϰ͘ϬϭͿ ,ĠŵĂƚŽůŽŐŝĞ;ϰϳ͘ϬϭͿ ƌĠĂŶŝŵĂƚŝŽŶŵĠĚŝĐĂůĞ;ϰϴ͘ϬϮͿ 'LJŶĠĐŽůŽŐŝĞͲŽďƐƚĠƚƌŝƋƵĞ;ϱϰ͘ϬϯͿ dŚĠƌĂƉĞƵƚŝƋƵĞ;ϰϴͲϬϰͿ ĂĐƚĠƌŝŽůŽŐŝĞͲsŝƌŽůŽŐŝĞ;ϰϱ͘ϬϭͿ WĠĚŝĂƚƌŝĞ;ϱϰ͘ϬϭͿ DĠĚ͘/Ŷ͖'ĠƌŝĂƚƌŝĞ;ϱϯ͘ϬϭͿ ŚŝƌƵƌŐŝĞŝŐĞƐƚŝǀĞ;ϱϮ͘ϬϮͿ ŶĂƚŽŵŝĞĞƚLJƚŽůŽŐŝĞƉĂƚŚŽůŽŐŝƋƵĞƐ;ϰϮ͘ϬϯͿ ŚŝƌƵƌŐŝĞǀĂƐĐƵůĂŝƌĞ;ϱϭ͘ϬϰͿ ĞƌŵĂƚŽͲsĠŶĠƌĠŽůŽŐŝĞ;ϱϬͲϬϯͿ DĂůĂĚŝĞƐ/ŶĨĞĐƚŝĞƵƐĞƐ͖DĂůĂĚŝĞƐdƌŽƉŝĐĂůĞƐ;ϰϱ͘ϬϯͿ WĠĚŝĂƚƌŝĞ;ϱϰ͘ϬϭͿ ƌŚƵŵĂƚŽůŽŐŝĞ;ϱϬ͘ϬϭͿ ĂĐƚĠƌŝŽůŽŐŝĞͲǀŝƌŽůŽŐŝĞ;ϰϱ͘ϬϭͿ EĞƵƌŽůŽŐŝĞ;ϰϵ͘ϬϭͿ ŶĚŽĐƌŝŶŽůŽŐŝĞ͕ŝĂďğƚĞĞƚDĂůĂĚŝĞƐDĠƚĂďŽůŝƋƵĞƐ;ϱϰ͘ϬϰͿ. ϰ.
(32) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ D/dZ^KE&ZE^^hE/sZ^/d^ͲWZd//E^,K^W/d>/Z^ D͘ D͘ DŵĞ D͘ DŵĞ D͘ D D D͘ D͘ DŵĞ D͘ DŵĞ DŵĞ DŵĞ DŵĞ D͘ DŵĞ D͘ DŵĞ D͘ DŵĞ D͘ D͘. ŵăũϯϭͬϬϴͬϮϬϭϴ. DZK^dd/ĂŵŝĞŶ EK>/>:ŽƐĠ ZEZͲWKD/Z'ŚŝƐůĂŝŶĞ ZKE^ZEŝĐŽůĂƐ hZ>ͲsEEK^&ĂŶŶLJ K'>/KůĂŝŶ KzE:ĠƌƀŵĞ &sZ'ƵŝůůĂƵŵĞ &K^^dŚŝĞƌƌLJ 'ZZ&&KZŽĚŽůƉŚĞ ,/Eh>dŚĂƌůŽƚƚĞ ,hDZdKůŝǀŝĞƌ >DzƌŝŐŝƚƚĞ >KE'ͲD/ZůŽĚŝĞ D'E/DĂƌŝĞͲEŽģůůĞ DKZ/WĂŵĞůĂ DKEdh/,ĞŶƌŝ Dh^^KͲ>^^>>^ĂŶĚƌĂ E4D/DŽƵƌĂĚ WKDZ^ŚƌŝƐƚĞůůĞ ^sK>>>/ŚĂƌůĞƐ ^/dͲWK>^</ďĂƌďĂƌĂ d^d:ĞĂŶ dKh>KEWŝĞƌƌĞ. LJƚŽůŽŐŝĞĞƚ,ŝƐƚŽůŽŐŝĞ;ϰϮ͘ϬϮͿ ŝŽƉŚLJƐŝƋƵĞĞƚDĠĚĞĐŝŶĞEƵĐůĠĂŝƌĞ;ϰϯ͘ϬϭͿ /ŵŵƵŶŽůŽŐŝĞ;ϰϳ͘ϬϯͿ ŶĂƚŽŵŝĞŚŝƌƵƌŐŝĞKƌƚŚŽƉĠĚŝƋƵĞĞƚdƌĂƵŵĂƚŽůŽŐŝƋƵĞ;ϰϮ͘ϬϭͿ ŶĂƚŽŵŝĞĞƚLJƚŽůŽŐŝĞƉĂƚŚŽůŽŐŝƋƵĞƐ;ϰϮ͘ϬϯͿ ĂĐƚĠƌŝŽůŽŐŝĞͲsŝƌŽůŽŐŝĞ;ϰϱ͘ϬϭͿ ZĂĚŝŽƚŚĠƌĂƉŝĞ;ϰϳ͘ϬϮͿ EĠƉŚƌŽůŽŐŝĞ;ϱϮ͘ϬϯͿ ĂĐƚĠƌŝŽůŽŐŝĞͲsŝƌŽůŽŐŝĞͲ,LJŐŝğŶĞ;ϰϱ͘ϬϭͿ WŚĂƌŵĂĐŽůŽŐŝĞ&ŽŶĚĂŵĞŶƚĂůĞ;ϰϴ͘ϬϯͿ ŝŽĐŚŝŵŝĞĞƚďŝŽůŽŐŝĞŵŽůĠĐƵůĂŝƌĞ;ϰϰ͘ϬϭͿ ŝŽƉŚLJƐŝƋƵĞĞƚDĠĚĞĐŝŶĞEƵĐůĠĂŝƌĞ;ϰϯ͘ϬϭͿ ĂĐƚĠƌŝůŽŐŝĞͲǀŝƌŽůŽŐŝĞ;ϰϱ͘ϬϭͿ LJƚŽůŽŐŝĞĞƚ,ŝƐƚŽůŽŐŝĞ;ϰϮ͘ϬϮͿ WŚLJƐŝŽůŽŐŝĞ;ϰϰ͘ϬϮͿ ĂƌĚŝŽůŽŐŝĞ;ϱϭ͘ϬϮͿ ĞƌŵĂƚŽůŽŐŝĞ;ϱϬ͘ϬϯͿ ŶĂƚŽŵŝĞĞƚLJƚŽůŽŐŝĞƉĂƚŚŽůŽŐŝƋƵĞƐ;ϰϮ͘ϬϯͿ ŝŽĐŚŝŵŝĞĞƚŝŽůŽŐŝĞŵŽůĠĐƵůĂŝƌĞ;ϰϰ͘ϬϭͿ WĂƌĂƐŝƚŽůŽŐŝĞĞƚŵLJĐŽůŽŐŝĞ;ϰϱ͘ϬϮͿ ŚŝƌƵƌŐŝĞŵĂdžŝůůŽͲĨĂĐŝĂůĞĞƚƐƚŽŵĂƚŽůŽŐŝĞ;ϱϱ͘ϬϯͿ /ŵŵƵŶŽůŽŐŝĞ;ϰϳ͘ϬϯͿ ƉŝĚĠŵŝŽůŽŐŝĞĐŽŶŽŵŝĞĚĞůĂ^ĂŶƚĠĞƚWƌĠǀĞŶƚŝŽŶ;ϰϲ͘ϬϭͿ ,ĠŵĂƚŽůŽŐŝĞĞƚdƌĂŶƐĨƵƐŝŽŶ;ϰϳ͘ϬϭͿ. ϱ.
(33) hE/sZ^/dE/^KW,/Ed/WK>/^ &h>dD/E. >ŝƐƚĞĚĞƐĞŶƐĞŝŐŶĂŶƚƐĂƵϭĞƌƐĞƉƚĞŵďƌĞϮϬϭϴăůĂ&ĂĐƵůƚĠĚĞDĠĚĞĐŝŶĞĚĞEŝĐĞ WZK&^^hZ^hE/sZ^/d^ D͘,K&>/'ZWŚŝůŝƉƉĞ. DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ. D/dZKE&ZE^^hE/sZ^/d^ D͘ZDKEĂǀŝĚ. DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ. WZK&^^hZ^'Z'^ DŵĞ. >E/ZĞďĞĐĐĂ. ŶŐůĂŝƐ. WZd//E,K^W/d>/ZhE/sZ^/d/Z D͘. hZEDĂƚƚŚŝĞƵ. hƌŽůŽŐŝĞ;ϱϮ͘ϬϰͿ. WZK&^^hZ^^^K/^ D͘ DŵĞ. 'ZKE'ŝůůĞƐ DKEE/ZƌŝŐŝƚƚĞ. DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ. D/dZ^KE&ZE^^^K/^ DŵĞ D͘ D͘. ŵăũϯϭͬϬϴͬϮϬϭϴ. ^dĠůŝŶĞ '^WZ/E/&ĂďƌŝĐĞ ,K'hEŝĐŽůĂƐ. DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ DĠĚĞĐŝŶĞ'ĠŶĠƌĂůĞ;ϱϯ͘ϬϯͿ. ϲ.
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