Educational course "Brain Parcellations and Functional Territories": Introduction to brain parcellation

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Introduction to brain parcellation

Sarah Genon

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Brain parcellation

From histology

To multimodal MRI

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Connectivity-based parcellation (CBP)

Neuroimaging scanner

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Type of connecti vity

Functional Co-plasticity Structural (white matter)

Data Task-based fMRI Resting state fMRI Anatomical MRI Diffusion MRI

Approach Task-based: Activation during

task

Resting-state:

Signal fluctuations at rest

Morphometry-based: Structural co-variation in the population Diffusion-based: Estimation of fiber direction Main method Meta-Analytic Connectivity Modeling (MACM) Cross-timepoint correlation in signal fluctuations (RSFC) Correlation of local GM across subjects (SC) Probabilistic diffusion tractography (PDT) 0 1 study c study a study b time voxel A voxel B 0 1 time time

How to estimate connectivity ?

Eickhoff, Yeo & Genon, 2018, Nat. Rev. Neurosci.

VBM-es' mated ' ssue values

VBM-estimated tissue value

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CBP: how ?

1) Region of Interest: Dorsal Premotor Cortex: Interface between prefrontal and primary motor

Genon et al., 2017, Cerebral Cortex

2) Connectivity matrix

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Reordered similarity matrix

Convergence between connectivity modalities

study c study a

study b

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CBPtools for different connectivity modalities:

Reuter et al., submitted

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Local microstructure VS

large-scale functional integration

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Local microstructure Connectivity markers

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Local microstructure

Ding & Van Hoesen, 2015

Lateral medial

Connectivity markers

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study c study a study b 2k 3k

Plachti et al., in press, Cerebral Cortex

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Amunts et al., 2006 Plachti et al., in press anterior

posterior

medial lateral

Local microstructure _{Connectivity markers}

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study c study a study b 2k 3k VBM-es' mated ' ssue values

Plachti et al., in press, Cerebral Cortex

Local microstructure and

Poster # T561

VBM-es' mated ' ssue values

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Take home messages

Brain parcellation

= a very wide set of methods to identify brain regions and/or networks From histology to MRI-based connectivity

To understand or to represent brain organization and data

Convergence and divergence between mapping features

CBPtool as a user-friendly tool for connectivity-based parcellation to

• Examine replicability across samples

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THANK YOU

CASIA Beijing Lingzhong Fan Düsseldorf Katrin Amunts Svenja Caspers Holger Schwender s.genon@fz-juelich.de @fzj_inm7 Simon Eickhoff

Cognitive Neuroinformatics Lab

WashU

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