HAL Id: hal-02740461
https://hal.inrae.fr/hal-02740461
Submitted on 2 Jun 2020
HAL is a multi-disciplinary open access
archive for the deposit and dissemination of
sci-entific research documents, whether they are
pub-lished or not. The documents may come from
teaching and research institutions in France or
abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est
destinée au dépôt et à la diffusion de documents
scientifiques de niveau recherche, publiés ou non,
émanant des établissements d’enseignement et de
recherche français ou étrangers, des laboratoires
publics ou privés.
Is P25 a realistic model to study the toxicity of titanium
dioxide TIO2 in the gastro-intestinal tract ?
William Dudefoi, Hélène Terrisse, Bernard Humbert, Marie-Hélène Ropers
To cite this version:
William Dudefoi, Hélène Terrisse, Bernard Humbert, Marie-Hélène Ropers. Is P25 a realistic model to
study the toxicity of titanium dioxide TIO2 in the gastro-intestinal tract ?. Nanosafe2014, Nov 2014,
Grenoble, France. 2015, Toxicology. �hal-02740461�
International Conference on Safe production and use of nanomaterials, Nanosafe 2014 November 18-20, 2014 – Grenoble, France
Session 4 TOXICOLOGY
N° 4 - TOXICOLOGY
IS P25 A REALISTIC MODEL TO STUDY THE TOXICITY OF TIO2 IN THE GASTRO-INTESTINAL TRACT?
William Dudefoi1, Hélène Terrisse2, Bernard Humbert2, Marie Hélène Ropers1, (1) INRA, UR1268 Biopolymères Interactions Assemblages, 44300 Nantes / France (2) Institut Matériaux Jean Rouxel IMN, UMR 6502 Univ Nantes – CNRS, 44322 Nantes / France
Due to its brightness and whiteness, TiO2 is used as pigments in various applications such as paints, cosmetic and food industries. In food, it is used for a long time and especially in confectionary, where it mainly constitutes the coating of sweets and chewing-gums. It is also present in some cheeses and sauces, low-fat products such as skimmed milk and ice-creams. Unfortunately it was recently discovered that food grade TiO2 exhibits a nano-sized fraction which can represent up to 36% of the particles. Due to the classification of TiO2 particles as potentially harmful for humans by inhalation, the toxicity of ingested nanoparticles of TiO2 are currently under investigation.
The toxicity of nano-sized particles of TiO2 was until now essentially investigated with the reference particles P25, which are a kind of TiO2 particles usually used for catalytic applications. To avoid any contest when TiO2 particles will be reevaluated for authorization as food grade additives, it should be checked that P25 and food grade particles are identical or at least similar. In this purpose, our work compares the physicochemical properties of P25 and food grade forms of TiO2 to decide whether P25 is a realistic model to study the toxicity of nano-sized food forms in the gastro-intestinal tract. Crystalline structures, primary particle sizes, agglomeration behaviors as a function of pH and surface reactivity, are the main properties that are compared and discussed. Some recommendations are finally addressed for further toxicological studies.
This work has been varied out in the framework of the Labex Serenade ANR-11-LABX-0064) and of the A*MIDEX project (ANR-11-IDEX-0001-02), funded by the «Investissements d’Avenir» French Government program managed by the French National Research Agency (ANR).
