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Synthesis of glucose-responsive hollow capsules

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XXIV

ièmes

Journées Scientifiques du G.T.R.V. / 24

th

Annual Meeting of the G.T.R.V.

PARIS, 7-9 Décembre 2009 / December, 7-9

th

, 2009

SYNTHESIS OF GLUCOSE RESPONSIVE HOLLOW CAPSULES

Alaimo D.

a

, Detrembleur C.

a

, Auzély-Velty R.

b

, Jérôme C.

a a

Center for Education and Research on Macromolecules (CERM), University of Liège (ULg),

Sart-Tilman B6a, 4000 Liège, Belgique.

b

Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), BP53, 38041

Grenoble cedex 9, France.

During the past decades, a large variety of micro- and nanocarriers have been developed in

order to improve efficiency, availability and toxicity profiles of drugs. In this field,

stimuli-responsive polymer multilayers have attracted great scientific interest because of the potential

applications in areas such as the controlled delivery or release of chemicals and drugs.

The objective of this work was to investigate the formation of glucose responsive hollow

microcapsules (5 microns) composed of polyelectrolyte copolymers composed of

carbohydrate-sensitive functions such as boronic acid and diols (PVOH) known for forming reversible

covalent ether bond. So, in presence of carbohydrates such as glucose, the ether bonds will be

reversibly broken and, consequently, the porosity of the glucose particles will change.

Therefore, polyelectrolyte copolymers were synthesized by control radical polymerization, i.e.

reversible addition-fragmentation chain transfer (RAFT, polyboronic acid) and cobalt-mediated

radical polymerization (CMRP, PVOH). Using these polyelectrolytes as poly anions and

poly(allylamine) (PAH) as a polycation, we undertook the formation of layer-by-layer capsules

starting with a template of CaCO3 microparticles which can be dissolve with EDTA leading to

the formation of hollow microcapsules. Dextran isothiocyanate (dextran-FITC) was used to fill

the CaCO3 micropartilces and for determied the porosity of the resulting capsules in fonction of

the glucose concentration. The sugar-dependent porosity is investigated by following the release

of encapsulated dextran-FITC by spectro-fluoroscopy.

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