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The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

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Figure 1. Effect of PHD2 Haplodeficiency on Tumor Growth and Metastasis (A) Tumor growth in PyMT +/+ and PyMT +/ mice (n = 20).
Figure 2. Effect of PHD2 Haplodeficiency on Cancer-Cell-Intrinsic Invasive Properties (A and B) Representative images of PyMT +/+ and PyMT +/ cancer cell cultures.
Figure 3. Effect of PHD2 Haplodeficiency on CAF Activation and Invasion
Figure 4. Effect of PHD2 Haplodeficiency on Matrix Production and Remodeling by CAFs (A–C) Sirius red staining of PyMT +/+ (A) and PyMT +/ (B) tumors
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