Recent advances in cancer treatment by Iron Chelators
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(2) Recent advances in cancer treatment by Iron Chelators Vincent Corcéa, Sébastien G. Gouina, Stéphanie Renaudb, c, François Gaboriaub, c, David Deniauda, a. R IP T. LUNAM Université, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France b INSERM, UMR 991, CHRU Pontchaillou, 35033 Rennes, France c Université de Rennes 1, 35043 Rennes, France. Abstract. AC. C. EP. TE. D. Graphical abstract. M. AN. U. SC. The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail..
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