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PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells

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Academic year: 2021

Partager "PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells"

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Figure 1: Schematic illustration of the IGF-1 mRNA transcript and protein structure. The  mRNA transcript possesses a 5’UTR and leader sequence derived primarily from exons 1  or 2 depending on the mRNA subtype
Figure 2: IGF-1R mRNA structure, processing and protein structure. IGF-1R’s functional  domains  are  indicated  above  corresponding  to  numbered  exons
Figure  3:  Schematic  representation  of  IGF-1  signaling  pathways.  IGF-1  functions  as  a  high-affinity ligand for IGF-1R in the cellular membrane, leading to autophosphorylation  of  IGF-1R  and  recruitment  of  the  IRS  adaptor  proteins
Table 1: HDAC classes and localization. This figure illustrates the four HDAC classes, the  members of each class and their localization (113, 114)
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