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Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells.

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Academic year: 2021

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Figure

Fig. 1. OPN-SI are overexpressedin PCa and support tumor growth.OPN-SI expression levels were analyzedby qRT-PCR and were repre- repre-sented by fold activation in relation to the sample presenting the lowest expressing levels.GAPDH was used as a normaliza
Fig. 2. OPNc and OPNb activate tumor formation by inducing proliferation. Tumors formed by each OPN-SI PC-3 overexpressing cells, as well as empty vector were analyzed for Ki-67 positive staining
Fig. 3. MMPs and VEGF are overexpressed in PCa cells overexpressing OPNb and OPNc isoforms
Fig. 4. OPNc and OPNb stimulate cell proliferation under serum starving conditions by stimulating cell survival

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