Rôle de la méthylation de l'ADN au locus du gène NEGR1 dans l'obésité et le neurodéveloppement des enfants
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(93)
(94)
(95)
(96) -. ↑ Mechanical stress
(97) - Dense ECM and fibrosis. . " '%' #"&!%#$ & . ↑ ECM deposition - Collagens - Elastin . %#&'%!# - Fibronectin
(98) " /)&( % &' #" ↑ M1 ATM and CLS .$#$'#&& $#*'& accumulation. ↓ Adipocyte adaptability
(99) . Physiologic ECM remodeling (degradation > deposition). . Insulin sensitivity. +. Pathophysiologic ECM remodeling (degradation < deposition).
(100)
(101) Inflammation. .
(102) . . $ $ "
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(104)
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