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IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

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Academic year: 2021

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Fig. 2 Anti-IL-7R α mAbs induce long-term control of skin in fl ammation. a Cutaneous erythema diameters measured daily after tuberculin intradermal injection in baboons treated with a single intravenous injection with 10 mg/kg of the site-1/2b IgG1 mAb (re
Fig. 3 Anti-human IL-7R α mAbs, epitopes, and antagonist/agonist signals. a Epitope determination by Hydrogen Deuterium Exchange and Mass Spectrometry (HDX-MS)
Fig. 4 Dual agonist/antagonist (site-1) anti-IL-7R α mAbs induce transcriptional modi fi cation and activation of human leukocytes
Fig. 5 Antagonist anti-IL-7R α mAb induces antigen-speci fi c memory T cell hyporesponsiveness
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