74. Interact Cardiovasc Thorac Surg. 2021 Nov 18;ivab294. doi: 10.1093/icvts/ivab294. Online ahead of print.
Subxiphoid-subcostal thoracoscopic thymectomy for seropositive myasthenia offers equivalent remission rates and potentially faster recovery
Peng Cao 1, Shan Hu 1, Wensheng Qu 2, Kangle Kong 1, Peng Han 1, Jiaqi Yue 1, Yu Deng 1, Xiangning Fu 1, Fan Li 1, Bo Zhao 1
• 1Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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• 2Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• PMID: 34792156
• DOI: 10.1093/icvts/ivab294
Keywords: Myasthenia gravis; Prognostic factor; Subxiphoid-subcostal; Thoracoscopic surgery; Thymectomy.
Review
75. Front Immunol. 2021 Nov 1;12:777606. doi: 10.3389/fimmu.2021.777606. eCollection 2021.
Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems Haixia Li 1, Shan Liu 1, Jinming Han 2 3, Shengxian Li 4, Xiaoyan Gao 1, Meng Wang 1, Jie Zhu 1 5, Tao Jin 1
• 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
• 2Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
• 3Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.
• 4Department of Urology, The First Hospital of Jilin University, Changchun, China.
• 5Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital, Solna, Sweden.
• PMID: 34790205
• PMCID: PMC8591135
• DOI: 10.3389/fimmu.2021.777606
Keywords: Guillain-Barré syndrome; Myasthenia gravis; inhibitors; multiple sclerosis; neuroimmune diseases; neuromyelitis optica spectrum disorder; toll-like receptors.
76. J Neuroinflammation. 2021 Nov 17;18(1):270. doi: 10.1186/s12974-021-02311-y.
Altered expression of fragile X mental retardation-1 (FMR1) in the thymus in autoimmune myasthenia gravis
Scott Thomas # 1, Odessa-Maud Fayet # 1, Frédérique Truffault 1, Elie Fadel 2, Bastien Provost 2, Abderaouf Hamza 3, Sonia Berrih-Aknin 1, Jean-Paul Bonnefont 3, Rozen Le Panse 4
• 1Sorbonne University, INSERM, Institute of Myology, Center of Research in Myology, F-75013, Paris, France.
• 2Marie Lannelongue Hospital, Paris-Sud University, Le Plessis-Robinson, France.
• 3Université de Paris, Institut Imagine UMR1163, Hôpital Universitaire Necker-Enfants Malades, AP-HP, Paris, France.
• 4Sorbonne University, INSERM, Institute of Myology, Center of Research in Myology, F-75013, Paris, France.
rozen.lepanse@upmc.fr.
#Contributed equally.
• PMID: 34789272
• PMCID: PMC8597299
• DOI: 10.1186/s12974-021-02311-y
Keywords: Autoimmunity; CTCF; FMR1; Fragile X syndromes; Inflammatory cytokines; Max; Myasthenia gravis; Thymic epithelial cells; Thymus.
77. Nutr Clin Pract. 2021 Nov 16. doi: 10.1002/ncp.10800. Online ahead of print.
High-dose vitamin C therapy for symptomatic deficiency in a patient with myasthenia gravis and Crohn's disease
Jill Murphree 1, Diana Wells Mulherin 2, Colleen Morton 3, Dawn Adams 4
• 1Nutrition Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• 2Clinical Pharmacy Specialist, Pharmacy Clinical Programs, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• 3Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• 4Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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• PMID: 34784069
• DOI: 10.1002/ncp.10800
Keywords: Crohn's disease; bleeding; ecchymosis; petechiae; scurvy; vitamin C; vitamin deficiency.
78. Neuromuscul Disord. 2021 Aug 20;S0960-8966(21)00612-X. Online ahead of print.
Predictors of outcome in patients with myasthenic crisis undergoing non-invasive mechanical ventilation: A retrospective 20 year longitudinal cohort study from a single Italian center
Erika Iori 1, Marco Mazzoli 1, Alessandra Ariatti 1, Elisabetta Bastia 2, Virginia Agnoletto 2, Manuela Gozzi 3, Alessandro Marchioni 4, Giuliana Galassi 5
• 1Department of Biomedical, Metabolic and Neural Sciences University Hospital, Modena, Italy.
• 2Division of Cardiology, Baggiovara Hospital, Modena, Italy.
• 3Department of Imaging, University Hospitals of Modena, Italy.
• 4Respiratory Disease Unit, Department of Medical and Surgical Sciences, University Hospitals of Modena, Italy.
• 5Department of Biomedical, Metabolic and Neural Sciences University Hospital, Modena, Italy. Electronic address:
giulianagalassi@alice.it.
• PMID: 34782245
• DOI: 10.1016/j.nmd.2021.08.008
Keywords: Extubation failure; Invasive ventilation; Myasthenic crisis; Non-invasive ventilation; Tracheostomy.
Published Erratum
79. J Neurol. 2021 Nov 15. doi: 10.1007/s00415-021-10896-w. Online ahead of print.
Correction to: Role of complement and potential of complement inhibitors in myasthenia gravis and neuromyelitis optica spectrum disorders: a brief review
Jayne L Chamberlain 1, Saif Huda 2, Daniel H Whittam, Marcelo Matiello 3, B Paul Morgan 4, Anu Jacob 2 5
• 1, Ruthin, UK. drjlc1000@gmail.com.
• 2Department of Neurology, The Walton Centre, Lower Lane, Liverpool, L9 7LJ, UK.
• 3Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
• 4School of Medicine, Henry Wellcome Building for Biomedical Research, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
• 5University of Liverpool, Liverpool, UK.
• PMID: 34779891
• DOI: 10.1007/s00415-021-10896-w Erratum for
Role of complement and potential of complement inhibitors in myasthenia gravis and neuromyelitis optica spectrum disorders: a brief review. Chamberlain JL, Huda S, Whittam DH, Matiello M, Morgan BP, Jacob A.J Neurol. 2021 May;268(5):1643-1664. doi: 10.1007/s00415-019-09498-4. Epub 2019 Sep 3. PMID: 31482201 Review.
80. Front Genet. 2021 Oct 28;12:756493. doi: 10.3389/fgene.2021.756493. eCollection 2021.
Immune-Related Molecular Profiling of Thymoma With Myasthenia Gravis
Jinman Zhuang 1 2 3, Maohao Guan 4, Maolin Liu 1 2 3, Yuhang Liu 1 2 3, Shuyan Yang 1 2 3, Zhijian Hu 1 2 3, Fancai Lai 4, Fei He 1 2 3
• 1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
• 2Fujian Provincial Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China.
• 3Fujian Digital Tumor Data Research Center, Fuzhou, China.
• 4Department of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
• PMID: 34777476
• PMCID: PMC8580862
• DOI: 10.3389/fgene.2021.756493
Keywords: bioinformatics; functional enrichment analysis; immune-related lncRNAs; mg; thymoma.
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81. Thorac Cancer. 2021 Nov 12. doi: 10.1111/1759-7714.14201. Online ahead of print.
LncRNA and mRNA expression associated with myasthenia gravis in patients with thymoma Ji Ke 1, Xin Du 1, Jian Cui 1, Lei Yu 1, Hui Li 2
• 1Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
• 2Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
• PMID: 34773374
• DOI: 10.1111/1759-7714.14201
Keywords: long non-coding RNA; mRNA; microarray analysis; myasthenia gravis; thymoma.
82. Int J Environ Res Public Health. 2021 Nov 4;18(21):11591. doi: 10.3390/ijerph182111591.
Development of a Model Care Pathway for Myasthenia Gravis
Anil Babu Payedimarri 1 2, Matteo Ratti 1 2, Riccardo Rescinito 1 2, Alessandra Vasile 1 2, Deborah Seys 2 3, Hervé Dumas 4, Kris Vanhaecht 2 3 5, Massimiliano Panella 1 2
• 1Department of Translational Medicine (DIMET), Università del Piemonte Orientale, 28100 Novara, Italy.
• 2European Pathway Association, 3000 Leuven, Belgium.
• 3Department of Public Health and Primary Care, Leuven Institute for Healthcare Policy, KU Leuven, 3000 Leuven, Belgium.
• 4UCB Pharma, 1630 Bulle, Switzerland.
• 5Department of Quality Management, University Hospitals Leuven, University of Leuven, 3000 Leuven, Belgium.
• PMID: 34770107
• PMCID: PMC8582978
• DOI: 10.3390/ijerph182111591
Keywords: care pathway; clinical pathway; core activities; critical pathway; integrated care pathway; key interventions;
model pathway; myasthenia gravis; process flow; quality indicators.
83. J Clin Med. 2021 Oct 27;10(21):4991. doi: 10.3390/jcm10214991.
Robotic vs. Transsternal Thymectomy: A Single Center Experience over 10 Years Luis Filipe Azenha 1, Robin Deckarm 1, Fabrizio Minervini 2, Patrick Dorn 1, Jon Lutz 1, Gregor Jan Kocher 1
• 1Division of General Thoracic Surgery, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
• 2Department of Thoracic Surgery, Cantonal Hospital Lucerne, 6000 Lucerne, Switzerland.
• PMID: 34768511
• PMCID: PMC8584938
• DOI: 10.3390/jcm10214991
Keywords: RATS; anterior mediastinal tumor resection; robotic; thymectomy.
Randomized Controlled Trial
84. Am J Ther. 2021 Nov-Dec 01;28(6):e631-e637. doi: 10.1097/MJT.0000000000001454.
Pharmacological Management of Myasthenia Gravis: A Century of Expert Opinions in Cecil Textbook of Medicine
Peter Manu 1, Liliana M Rogozea 2, Corina Roman-Filip 3
• 1Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
• 2Basic, Preventive and Clinical Sciences Department, Transilvania University, Brasov, Romania; and.
• 3Department of Neurology, University Lucian Blaga, Sibiu, Romania.
• PMID: 34757964
• DOI: 10.1097/MJT.0000000000001454
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Review
85. Neuromuscul Disord. 2021 Oct 8;S0960-8966(21)00668-4. doi: 10.1016/j.nmd.2021.09.013. Online ahead of print.
Effectiveness of thymectomy in juvenile myasthenia gravis and clinical characteristics associated with better outcomes
Wei Chin Ng 1, Louise Hartley 2
• 1Barts and The London School of Medicine and Dentistry, Whitechapel, London E1 2AD, United Kingdom.
• 2Department of Paediatric Neurology, The Royal London Hospital, London E1 1BB, United Kingdom.
• PMID: 34756789
• DOI: 10.1016/j.nmd.2021.09.013
Keywords: Juvenile myasthenia gravis; Myasthenia gravis; Paediatric; Thymectomy.
86. Acta Neurol Scand. 2021 Nov 8. doi: 10.1111/ane.13549. Online ahead of print.
Comorbidities in older patients with myasthenia gravis - Comparison between early- and late-onset disease
Elzbieta Klimiec-Moskal 1, Mary Quirke 2, Maria Isabel Leite 2
• 1Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
• 2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK.
• PMID: 34750811
• DOI: 10.1111/ane.13549
Keywords: Myasthenia gravis; autoimmune disease; comorbidity; early-onset myasthenia gravis; late-onset myasthenia gravis.
Published Erratum
87. Neurotherapeutics. 2021 Nov 8. doi: 10.1007/s13311-021-01144-0. Online ahead of print.
Correction to: Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: a Multicenter Retrospective Cohort Study
Huanhuan Li 1, Zhe Ruan 1, Feng Gao 2, Hongyu Zhou 3, Rongjing Guo 1, Chao Sun 1, Quan Xu 4, Qiang Lu 5, Yongan Zhou 5, Zhengwei Zhao 5, Liping Yu 6, Songdi Wu 7, Tao Lei 8, Ting Gao 1, Yonglan Tang 1, Chunhong Li 1, Feiyan Huo 1, Ying Zhu 1, Jie Sun 1, Baoli Tang 1, Min Zhang 1, Yanwu Gao 1, Xiaodan Lu 1, Zhuyi Li 9, Ting Chang 10
• 1Department of Neurology, Tangdu Hospital, the Fourth Military Medical University, 569 XinSi Road, Xi'an 710038, China.
• 2Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
• 3Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
• 4Department of Thoracic Surgery, Jiangxi Provincial People's Hospital Affiliated To Nanchang University, Nanchang, China.
• 5Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
• 6Department of Neurology, Xianyang First People's Hospital, Xianyang, China.
• 7Department of Neurology, Xi'an No.1 Hospital, Xi'an, China.
• 8Department of Neurology, Xi'an Fourth Hospital, Xi'an, China.
• 9Department of Neurology, Tangdu Hospital, the Fourth Military Medical University, 569 XinSi Road, Xi'an 710038, China. lizhuyiafu@163.com.
• 10Department of Neurology, Tangdu Hospital, the Fourth Military Medical University, 569 XinSi Road, Xi'an 710038, China. changting1981@163.com.
• PMID: 34750752
• DOI: 10.1007/s13311-021-01144-0 Erratum for
Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study. Li H, Ruan Z, Gao F, Zhou H, Guo R, Sun C, Xu Q, Lu Q, Zhou Y, Zhao Z, Yu L, Wu S, Lei T, Gao T, Tang Y, Li C, Huo F, Zhu Y, Sun J, Tang B, Zhang M, Gao Y, Lu X, Li Z, Chang T.Neurotherapeutics. 2021 Oct 8. doi: 10.1007/s13311-021-01129-z. Online ahead of print. PMID: 34625864
MYOBASE link : https://www.myobase.org/index.php?lvl=notice_display&id=73594
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88. Intern Med. 2021 Nov 6. doi: 10.2169/internalmedicine.8460-21. Online ahead of print.
Association of Smoking and Generalized Manifestations of Myasthenia Gravis
Yusei Miyazaki 1, Masaaki Niino 2, Ken Sakushima 3, Eri Takahashi 2, Ryoji Naganuma 1, Itaru Amino 1, Sachiko Akimoto 1, Naoya Minami 1, Ichiro Yabe 3, Seiji Kikuchi 1
• 1Departments of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
• 2Departments of Clinical Research, National Hospital Organization Hokkaido Medical Center, Japan.
• 3Department of Neurology, Hokkaido University Graduate School of Medicine, Japan.
• PMID: 34744112
• DOI: 10.2169/internalmedicine.8460-21
Keywords: Activities of daily living; age of onset; generalization; myasthenia gravis; smoking.
89. Ann Thorac Surg. 2021 Nov 1;S0003-4975(21)01832-4. Online ahead of print.
Robotic thymectomy for thymomas: a retrospective follow-up study in the Netherlands
Florit Marcuse 1, Monique Hochstenbag 2, Marc H V De Baets 3, Gerben Bootsma 4, Alexander P W M Maat 5, Janneke G Hoeijmakers 6, Marlies Keijzers 7, Myrurgia Abdul Hamid 8, Dirk De Ruysscher 9, Jos J G Maessen 10
• 1Department of Pulmonology, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: florit.marcuse@mumc.nl.
• 2Department of Pulmonology, Maastricht University Medical Center+, Maastricht, the Netherlands.
• 3School for Mental Health and Neuroscience, Maastricht University+, Maastricht, the Netherlands; Department of Cardiothoracic surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
• 4Department of Pulmonology, Zuyderland Medical Center, Heerlen, The Netherlands.
• 5Department of Cardiothoracic surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
• 6School for Mental Health and Neuroscience, Maastricht University+, Maastricht, the Netherlands; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
• 7Department of Vascular Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
• 8Department of Pathology, Maastricht University Medical Center+, Maastricht, the Netherlands.
• 9Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Center+, Maastricht, the Netherlands, GROW School for Oncology.
• 10Department of Cardiothoracic surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
• PMID: 34736927
• DOI: 10.1016/j.athoracsur.2021.09.056 Keywords: follow-up; robotic thymectomy; thymomas.