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77. Front Cell Dev Biol. 2021 Nov 22;9:745897. doi: 10.3389/fcell.2021.745897. eCollection 2021.

A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics

Virginia M Smith 1 2, Huan Nguyen 1, John W Rumsey 2, Christopher J Long 2, Michael L Shuler 2, James J Hickman 1 2

1Hybrid Systems Lab, NanoScience Technology Center, University of Central Florida, Orlando, FL, United States.

2Hesperos, Inc., Orlando, FL, United States.

• PMID: 34881241

• PMCID: PMC8645836

• DOI: 10.3389/fcell.2021.745897

Keywords: acetylcholine receptor; autoantibodies; disease pathology; human-on-a-chip; induced pluripotent stem cells (iPSCs); microphysiological systems; myasthenia gravis; neuromuscular junction (NMJ).

78. Biomed Res Int. 2021 Dec 6;2021:5854056. doi: 10.1155/2021/5854056. eCollection 2021.

Analysis on the Clinical Effect of High-Dose Glucocorticoids Combined with Immunosuppressants on Patients with Myasthenia Gravis Undergoing Video-Assisted Thoracoscopic Surgery

Pei Liu 1, Haoyue Wang 1, Jiejie Hu 1, Xiaobin Zhai 1, Zhaoming Ge 1

1Department of Neurology, Lanzhou University Second Hospital, Lanzhou, 730030 Gansu Province, China.

• PMID: 34912892

• PMCID: PMC8668280

• DOI: 10.1155/2021/5854056

Review

79. Cureus. 2021 Nov 9;13(11):e19416. doi: 10.7759/cureus.19416. eCollection 2021 Nov.

Rituximab in the Management of Refractory Myasthenia Gravis and Variability of Its Efficacy in Anti-MuSK Positive and Anti-AChR Positive Myasthenia Gravis

Sanjiv Bastakoti 1 2 3, Saru Kunwar 1, Sujan Poudel 1, Jonathan Quinonez 4, Seema Bista 1, Navpreet Singh 1, Vivek Jha 1, Samir Ruxmohan 5, Sylvia Paesani 6, Wilson Cueva 5, Jack Michel 7

1Division of Research & Acadamic Affairs, Larkin Community Hospital, South Miami, USA.

2Internal Medicine, KIST Medical College & Teaching Hospital, Kathmandu, NPL.

3Intensive Care Unit, Metrocity Hospital and Research Center, Pokhara, NPL.

4Neurology/Osteopathic Neuromuscular Medicine, Larkin Community Hospital, South Miami, USA.

5Neurology, Larkin Community Hospital, South Miami, USA.

6Family Medicine, Larkin Community Hospital, South Miami, USA.

7Internal Medicine, Larkin Health System, South Miami, USA.

• PMID: 34909332

• PMCID: PMC8660595

• DOI: 10.7759/cureus.19416

Keywords: anti-achr antibody; monoclonal antibody; myasthenia gravis; refractory myasthenia; rituximab.

80. Sci Rep. 2021 Dec 14;11(1):23920. doi: 10.1038/s41598-021-03357-x.

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis

Tianfeng Wang 1, Si Xu 1, Huixue Zhang 1, Xiaoyu Lu 1, Shuang Li 1, Li Liu 1, Xiaotong Kong 1, Hongyu Gao 1, Xu Wang 1, Shangwei Ning 2, Jianjian Wang 3, Lihua Wang 4

1Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150081, Heilongjiang, China.

2College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.

ningsw@ems.hrbmu.edu.cn.

3Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150081, Heilongjiang, China. wangjian_427@163.com.

4Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150081, Heilongjiang, China. wanglh211@163.com.

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021)

• PMID: 34907261

• PMCID: PMC8671434

• DOI: 10.1038/s41598-021-03357-x

81. J Neurol Sci. 2021 Dec 8;432:120084. doi: 10.1016/j.jns.2021.120084. Online ahead of print.

Comparison of fixed cell-based assay to radioimmunoprecipitation assay for acetylcholine receptor antibody detection in myasthenia gravis

Ario Mirian 1, Michael W Nicolle 1, Pamela Edmond 2, Adrian Budhram 3

1Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.

2Department of Pathology and Laboratory Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada.

3Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada. Electronic address: Adrian.budhram@lhsc.on.ca.

• PMID: 34906880

• DOI: 10.1016/j.jns.2021.120084

Keywords: Acetylcholine receptor antibody; Cell-based assay; Myasthenia gravis; Radioimmunoprecipitation assay.

Case Reports

82. Cureus. 2021 Nov 5;13(11):e19268. doi: 10.7759/cureus.19268. eCollection 2021 Nov.

The Eldest Female Case of Myasthenia Gravis with an Unusual Presentation: Aspiration Pneumonia as the Initial Manifestation

Yuya Masuda 1 2, Teru Kumagi 1, Noriyuki Miyaue 3, Yuko Hosokawa 3, Hayato Yabe 3

1Postgraduate Medical Education Center, Ehime University Hospital, Toon, JPN.

2Postgraduate Medical Education Center, Saiseikai Matsuyama Hospital, Matsuyama, JPN.

3Neurology, Saiseikai Matsuyama Hospital, Matsuyama, JPN.

• PMID: 34900462

• PMCID: PMC8648139

• DOI: 10.7759/cureus.19268

Keywords: aspiration pneumonia; etiology; myasthenia gravis; super-elderly; unusual presentation.

83. Geburtshilfe Frauenheilkd. 2021 Dec 8;81(12):1301-1306. doi: 10.1055/a-1541-7964. eCollection 2021 Dec.

Recommendations of the AGG (Section Maternal Disease) for Myasthenia Gravis in Pregnancy Maritta Kühnert 1, Markus Schmidt 2, Bettina Kuschel 3, Ute Margaretha Schäfer-Graf 4

1Obstetrics, UFK Marburg, Marburg, Germany.

2Gynecology & Obstetrics, Sana Kliniken Duisburg GmbH, Duisburg, Germany.

3Frauenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.

4Perinatalzentrum, Klinik für Gynäkologie und Geburtshilfe, Berlin, Germany.

• PMID: 34899044

• PMCID: PMC8654508

• DOI: 10.1055/a-1541-7964

Keywords: labor; myasthenia gravis; neonatal features; pregnancy.

84. Brain Behav. 2021 Dec 12;e2451. doi: 10.1002/brb3.2451. Online ahead of print.

Illness perception characteristics and influencing factors in adult patients with myasthenia gravis in China

Le Xu 1, Xia Wang 1, Yafeng Cui 1, Yanghua Tian 1, Nong Zhou 1, Juanjuan Zhang 1, Hiaxia Ji 1, Xiumei Cheng 1, Qin Zhang 1, Qingfeng Li 1, Panpan Hu 1, Long Zhang 1

1Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

• PMID: 34898040

• DOI: 10.1002/brb3.2451

Keywords: illness perception; influencing factors; myasthenia gravis; questionnaire; variance and multivariate linear regression.

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021)

Review

85. Can J Neurol Sci. 2021 Dec 13;1-25. doi: 10.1017/cjn.2021.508. Online ahead of print.

Complement Inhibition in Myasthenia Gravis and Neuromyelitis Optica Spectrum Disorder Dubravka Dodig, Angela Genge, Daniel Selchen, Mark S Freedman

• PMID: 34895385

• DOI: 10.1017/cjn.2021.508

86. World J Surg Oncol. 2021 Dec 9;19(1):342. doi: 10.1186/s12957-021-02430-z.

Non-intubated uniportal subxiphoid thoracoscopic extended thymectomy for thymoma associated with myasthenia gravis

Zhengcheng Liu 1, Louqian Zhang 1, Weifeng Tang 1, Rusong Yang 2

1Department of Cardiovascular and Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210029, China.

2Department of Cardiovascular and Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210029, China. njyrs_md@188.com.

• PMID: 34886860

• PMCID: PMC8655993

• DOI: 10.1186/s12957-021-02430-z

Keywords: Myasthenia gravis; Non-intubated; Subxiphoid; Thymectomy; Uniport.

Review

87. Cancers (Basel). 2021 Nov 23;13(23):5887. doi: 10.3390/cancers13235887.

Difficult Decisions in Minimally Invasive Surgery of the Thymus Ankit Dhamija 1, Jahnavi Kakuturu 2, J W Awori Hayanga 2, Alper Toker 2

1Department of Cardiothoracic Surgery, Stony Brook University, Stony Brook, NY 11794, USA.

2Department of Cardiovascular and Thoracic Surgery, West Virginia University School of Medicine Morgantown, Morgantown, WV 26506, USA.

• PMID: 34884996

• PMCID: PMC8657073

• DOI: 10.3390/cancers13235887 Keywords: myasthenia gravis; surgery; thymus.

Review

88. Int J Mol Sci. 2021 Nov 30;22(23):12964. doi: 10.3390/ijms222312964.

A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

Soudeh Ghafouri-Fard 1, Tahereh Azimi 2, Bashdar Mahmud Hussen 3, Mohammad Taheri 4, Reza Jalili Khoshnoud 5

1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.

2Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.

3Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil 44001, Iraq.

4Institute of Human Genetics, Jena University Hospital, 07747 Jena, Germany.

5Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.

• PMID: 34884767

• PMCID: PMC8657981

• DOI: 10.3390/ijms222312964

Keywords: biomarkers; expression; lncRNA; miRNA; myasthenia gravis.

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021) 89. Front Neurol. 2021 Nov 22;12:790941. doi: 10.3389/fneur.2021.790941. eCollection 2021.

Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort

Jianquan Shi 1, Xiao Huan 2 3, Lei Zhou 2 3, Jianying Xi 2 3, Jie Song 2 3, Ying Wang 4, Sushan Luo 2 3, Chongbo Zhao 2 3

1Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

2Department of Neurology, Huashan Hospital Fudan University, Shanghai, China.

3National Center for Neurological Disorders, Shanghai, China.

4Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.

• PMID: 34880829

• PMCID: PMC8645996

• DOI: 10.3389/fneur.2021.790941

Keywords: autoimmune diseases; clinical characteristics; comorbidities; myasthenia gravis; percentage.

90. Dtsch Arztebl Int. 2022 Feb 4;(Forthcoming):arztebl.m2021.0353. Online ahead of print.

Pregnancy and Autoimmune Disease: Diseases of the Nervous System, Connective Tissue, and the Bowel

Waltraut Maria Merz, Rebecca Fischer-Betz, Kerstin Hellwig, Georg Lamprecht, Ulrich Gembruch

• PMID: 34874264

• DOI: 10.3238/arztebl.m2021.0353

91. Rev Neurol (Paris). 2021 Nov 27;S0035-3787(21)00768-2. Online ahead of print.

Immunoglobulin shortage: Practice modifications and clinical outcomes in a reference centre E N'kaoua 1, S Attarian 2, E Delmont 3, E Campana-Salort 3, A Verschueren 3, A-M Grapperon 3, E Mestivier 1, M Roche 4

1Assistance Publique-Hôpitaux de Marseille, Service Central des Opérations Pharmaceutiques (SCOP), Marseille, France.

2Assistance Publique-Hôpitaux de Marseille, Centre de référence des maladies neuromusculaires et SLA, Hôpital Timone, Marseille, France; Aix Marseille Univ, Inserm UMR 1251, Marseille, France. Electronic address:

shahram.attarian@ap-hm.fr.

3Assistance Publique-Hôpitaux de Marseille, Centre de référence des maladies neuromusculaires et SLA, Hôpital Timone, Marseille, France.

4Assistance Publique-Hôpitaux de Marseille, Service Central des Opérations Pharmaceutiques (SCOP), Marseille, France; Aix Marseille Univ, ICR, UMR CNRS7273, Marseille, France.

• PMID: 34872746

• DOI: 10.1016/j.neurol.2021.10.004

Keywords: Drug shortage; Dysimmune neuromuscular diseases; Intravenous immunoglobulins; Prescription drugs;

92. Medicine (Baltimore). 2021 Nov 5;100(44):e27688. doi: 10.1097/MD.0000000000027688.

Effect of Buzhong Yiqi decoction on anti-acetylcholine receptor antibody and clinical status in juvenile ocular myasthenia gravis

Jiaduo Li 1, Guoyan Qi 1, Yaling Liu 2

1Center of Treatment of Myasthenia Gravis, People's Hospital of Shijiazhuang Affiliated to Hebei Medical University, China.

2Gastroenterology Department, People's Hospital of Shijiazhuang Affiliated to Hebei Medical University, China.

• PMID: 34871253

• PMCID: PMC8568406

• DOI: 10.1097/MD.0000000000027688

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021) Case Reports

93. Eur Heart J Case Rep. 2021 Aug 18;5(11):ytab342. doi: 10.1093/ehjcr/ytab342. eCollection 2021 Nov.

A case report of immune checkpoint inhibitor-related steroid-refractory myocarditis and myasthenia gravis-like myositis treated with abatacept and mycophenolate mofetil

Mette Syberg Jespersen 1, Søren Fanø 2, Christian Stenør 3, Anne Kirstine Møller 4

1National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.

2Department of Cardiology, Copenhagen University Hospital, Herlev, Denmark.

3Department of Neurology, Copenhagen University Hospital, Herlev, Denmark.

4Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.

• PMID: 34870082

• PMCID: PMC8637790

• DOI: 10.1093/ehjcr/ytab342

Keywords: Case report; Immune checkpoint inhibitors; Immune-related adverse events; Management of immune-related myocarditis; Renal cell carcinoma; Troponin I.

94. Front Neurol. 2021 Nov 18;12:767961. doi: 10.3389/fneur.2021.767961. eCollection 2021.

Patients With Myasthenia Gravis With Acute Onset of Dyspnea: Predictors of Progression to Myasthenic Crisis and Prognosis

Yangyu Huang 1, Ying Tan 1, Jiayu Shi 1, Ke Li 1, Jingwen Yan 1, Yuzhou Guan 1

1Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

• PMID: 34867753

• PMCID: PMC8637205

• DOI: 10.3389/fneur.2021.767961

Keywords: early-onset; impending myasthenic crisis; intravenous immunoglobulin; mechanical ventilation; myasthenia gravis; myasthenic crisis; post-intervention status.

95. Front Neurol. 2021 Nov 19;12:680141. doi: 10.3389/fneur.2021.680141. eCollection 2021.

Association Between Myasthenia Gravis and Memory: A Systematic Review and Meta-Analysis Xiaoling Zhou 1 2, Yifei Zhou 3, Jianian Hua 1 2, Qun Xue 1 2

1Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.

2Medical College of Soochow University, Suzhou, China.

3Department of Gastroenterology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

• PMID: 34867702

• PMCID: PMC8640249

• DOI: 10.3389/fneur.2021.680141

Keywords: cognition; delayed recall memory; immediate recall memory; memory; meta-analysis; myasthenia gravis;

neuropsychology.

96. Rev Mal Respir. 2021 Dec 2;S0761-8425(21)00400-9. doi: 10.1016/j.rmr.2021.11.001. Online ahead of print.

[Introduction of an anticholinesterase drug in the context of myasthenia, in a severe asthmatic patient]

[Article in French]

G Ghrenassia 1, L Grassion 1, M Molimard 2, P Sanchez-Pena 3, C Raherison 4

1Service de pneumologie, hôpital Haut-Lévêque, CHU de Bordeaux, Bordeaux cedex, France.

2Service de pharmacologie médicale, CHU de Bordeaux-Université de Bordeaux-Inserm CR1219, 33076 Bordeaux cedex, France.

3Département de pharmacologie médicale, centre de pharmacovigilance, CHU de Bordeaux 33076 Bordeaux cedex, France.

4Service de pneumologie, hôpital Haut-Lévêque, CHU de Bordeaux, Bordeaux cedex, France; Service des maladies respiratoires, pôle cardiothoracique, CHU de Bordeaux, U1219 BPH Bordeaux population health research center, team: EPICENE, UMR1219; ISPED Institut de santé publique d'épidémiologie et de développement, avenue Magellan, 33604 Bordeaux, France. Electronic address: chantal.raherison@chu-bordeaux.fr.

• PMID: 34865952

• DOI: 10.1016/j.rmr.2021.11.001

Keywords: Anticholinergic; Anticholinergique; Anticholinesterase; Anticholinestérasique; Asthme sévère; Severe asthma.

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021) 97. J Neuroophthalmol. 2021 Oct 22. doi: 10.1097/WNO.0000000000001425. Online ahead of print.

Interobserver and Intra-Observer Reliability of Eyelid Tests for Ocular Myasthenia Gravis Thanchat Jienmaneechotchai 1, Supanut Apinyawasisuk, Supharat Jariyakosol, Parima Hirunwiwatkul

1Ophthalmology Department (TJ, SA, SJ, PH), King Chulalongkorn Memorial Hospital, Bangkok, Thailand; and Department of Ophthalmology (TJ, SA, SJ, PH), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

• PMID: 34860746

• DOI: 10.1097/WNO.0000000000001425

98. J Neuroophthalmol. 2021 Oct 22. doi: 10.1097/WNO.0000000000001438. Online ahead of print.

The Use of the Saccadometer to Identify Saccadic Characteristics in Myasthenia Gravis: A Pilot Study Craig Murray 1, David Newsham, Fiona Rowe, Carmel Noonan, Ian B Marsh

1University of Liverpool (CM, DN, FR), Liverpool, United kingdom; and Liverpool University Hospitals NHS Foundation Trust (CN, IM), Liverpool, United kingdom.

• PMID: 34860741

• DOI: 10.1097/WNO.0000000000001438

99. Front Genet. 2021 Nov 11;12:758041. doi: 10.3389/fgene.2021.758041. eCollection 2021.

Calculation of Similarity Between 26 Autoimmune Diseases Based on Three Measurements Including Network, Function, and Semantics

Yanjun Ding 1 2, Mintian Cui 1, Jun Qian 2, Chao Wang 1, Qi Shen 1, Hongbiao Ren 1, Liangshuang Li 1, Fengmin Zhang 2, Ruijie Zhang 1

1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

2Department of Microbiology, WU Lien-Teh Institute, Harbin Medical University, Harbin, China.

• PMID: 34858474

• PMCID: PMC8632457

• DOI: 10.3389/fgene.2021.758041

Keywords: ADs; autoimmune tautology; functional similarity; genetic susceptibility; network similarity; semantic similarity.

Case Reports

100. BMJ Case Rep. 2021 Dec 2;14(12):e246005. doi: 10.1136/bcr-2021-246005.

Post-thymectomy myasthenia gravis: a case report and systematic review of literature Louise Gurowich 1 2, Gabriel Yiin 2, Adam Maxwell 2, Alexandra Rice 3

1General Surgery, Taunton and Somerset NHS Foundation Trust, Taunton, UK louise.gurowich@nhs.net.

2Neurology, Swindon and Marlborough NHS Trust, Swindon, UK.

3Histopathology, Royal Brompton Hospital, London, UK.

• PMID: 34857591

• PMCID: PMC8640658 (available on 2023-12-02)

• DOI: 10.1136/bcr-2021-246005

Keywords: cardiothoracic surgery; endocrine cancer; neurology; neuromuscular disease.

101. Neurology. 2021 Dec 2;10.1212/WNL.0000000000013121. Online ahead of print.

Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study

Richard J Nowak 1, Christopher S Coffey 2, Jonathan M Goldstein 3, Mazen M Dimachkie 4, Michael Benatar 5, John T Kissel 6, Gil I Wolfe 7, Ted M Burns 8, Miriam L Freimer 6, Sharon Nations 9, Volkan Granit 10 5, A Gordon Smith 11, David P Richman 12, Emma Ciafaloni 13, Muhammad T Al-Lozi 14, Laura Ann Sams 15, Dianna Quan 16, Eroboghene

Ubogu 17, Brenda Pearson 2, Aditi Sharma 18 19, Jon W Yankey 2, Liz Uribe 2, Michael Shy 20, Anthony A Amato 21, Robin Conwit 22, Kevin C O'Connor 18, David A Hafler 18, Merit E Cudkowicz 23, Richard J Barohn 4 24, NeuroNEXT NN103 BeatMG Study Team

1Department of Neurology, Yale University School of Medicine, New Haven, CT richard.nowak@yale.edu.

2Clinical Trials Statistical & Data Management Center, University of Iowa, Iowa City, IA.

Bibliographie sur les maladies neuromusculaires Bibliography of neuromuscular disorders

n° 2021-12-1 du 3 au 16 décembre 2021 (December 3 to 16, 2021)

3Department of Neurology, Hospital for Special Surgery, New York, NY.

4Department of Neurology, Kansas University School of Medicine, Kansas City, KS.

5Department of Neurology, University of Miami Miller School of Medicine, Miami, FL.

6Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH.

7Department of Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY.

8Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA.

9Department of Neurology, University of Texas Southwestern Medical School, Dallas, TX.

10Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.

11Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT.

12Department of Neurology, University of California Davis School of Medicine, Sacramento, CA.

13Department of Neurology, University of Rochester School of Medicine & Dentistry, Rochester, NY.

14Department of Neurology, Washington University School of Medicine, St. Louis, MO.

15Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH.

16Department of Neurology, University of Colorado School of Medicine, Aurora, CO.

17Department of Neurology, The University of Alabama at Birmingham School of Medicine, Birmingham, AL.

18Department of Neurology, Yale University School of Medicine, New Haven, CT.

19Department of Neurology, University of Iowa, Iowa City, IA.

20Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, IA.

21Department of Neurology, Brigham and Women's Hospital, Boston, MA.

22Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Rockville, MD.

23Department of Neurology, Massachusetts General Hospital, Boston, MA.

24Department of Neurology, University of Missouri, Columbia, MO.

• PMID: 34857535

• DOI: 10.1212/WNL.0000000000013121