• Evaluation des facteurs maternels précoces (épigenèse) dans l’ontogenèse du comportement anxieux chez la descendance.
• Etude de l’impact du stress gestationnel sur les changements de plasticité cérébrale associés à la maternité (hippocampe et bulbes olfactifs)
• Recherche des mécanismes neurobiologiques sous tendant les changements des comportements émotionnels et de la fonction mnésique lors de la maternité.
Ce projet s’inscrit dans la continuité de la collaboration établie avec le Pr Luis Miguel Garcia-Segura (CSIC, Madrid) et le Dr Margarita Perez-Martin (Université de Malagà).
Résumé :
L’accouchement et le début de l’expérience maternelle constituent une expérience à haute charge allostasique pour la mère primipare (Rosenblatt et Snowdon, 1996). La qualité du comportement maternel joue un rôle décisif pour la survie de la descendance et détermine en partie l’épigenèse de son axe du stress (Champagne et Meaney, 2006). Par ailleurs, de profonds changements des systèmes hypothalamique, mésolimbique et olfactifs ont été décrits chez la mère (Fleming et coll., 1999 ; Shingo et coll., 2003, figure 20). Bien que cette plasticité joue un rôle clefs dans le comportement maternel, elle a aussi des conséquences importantes sur d’autres fonctions, liées à ces systèmes, comme la mémoire et la motivation. Nous avons démontré récemment que l’initiation de la maternité constituait une période critique pour la fonction hippocampique (Darnaudéry et coll., 2007). Nos travaux antérieurs ont permis de mettre en évidence que le stress lors de la gestation a des conséquences durable sur la physiologie et le comportement des femelles (Darnaudéry et coll., 2004). Le but de notre projet est d’explorer le rôle des facteurs maternels lors de la lactation dans l’influence du stress maternel sur l’adaptation future de la descendance. Par ailleurs, nous examinerons les changements de la plasticité cérébrale au cours de la gestation ; et les mécanismes neurobiologiques sous-tendant les changements comportementaux associés à la maternité. Pour ce faire, nous caractériserons les changements comportementaux associés non seulement aux fonctions reproductives, mais également aux fonctions
cognitives, émotionnelles et motivationnelles chez des femelles soumises à un stress gestationnel et nous étudierons les mécanismes moléculaires et cellulaires sous-jacents, en particulier par l’étude de la plasticité cérébrale (facteurs de transcription constitutifs et inductible dans l’hippocampe et les régions mésolimbiques).
La réalisation de ce projet pourra se faire grâce au recrutement d’un étudiant en thèse.
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