KANG KW, CHOI SY, CHO MK,

Thrombin induces nitric-oxide synthase via Galpha12/13-coupled protein kinase C dependent I-kappa B alpha phosphorylation and JNK-mediated I-kappa B alpha degradation.

J Biol Chem 2003; 278: 17368-78.

48. B. Vallet, B. Tavernier.

Physiopathologie du choc septique consensus d’actualisation SFAR 1999, 41 congrès national d’anesthésie et de réanimation, 1999 Elsevier, Paris et SFAR. 691-703.

49. Kim WY, Hong SB.

Sepsis and acute respiratory distress syndrome: recent update. Tuberc Respir Dis (Seoul) 2016.

50. Mikkelsen ME, Shah CV, Meyer NJ,

The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis. Shock 2013.

51. Hotchkiss RS, Moldawer LL, Opal SM,

Sepsis and septic shock HHS public access. Nat Rev Dis Primers 2017.

52. Bagshaw SM, Uchino S, Bellomo R,

Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes.

Clin J Am Soc Nephrol 2007.

53. De Mendonc¸a A, Vincent JL, Suter PM,

Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score.

Intensive Care Med 2000.

54. Zarjou A, Agarwal A.

Sepsis and acute kidney injury. J Am Soc Nephrol 2011.

55. Godin M, Murray P, Mehta RL.

Clinical approach to the patient with AKI and sepsis. Semin Nephrol 2015.

56. Barbar SD, Clere-Jehl R, Bourredjem A,

Timing of renal-replacement therapyin patients with acute kidney injury and sepsis. N Engl J Med 2018.

57. Goyette RE, Key NS, Ely EW.

Hematologic changes in sepsis and their therapeutic implications. Semin Respir Crit Care Med 2004.

58. Mammen EF.

The haematological manifestations of sepsis. J Antimicrob Chemother 1998.

59. Rhodes A, Evans LE, Alhazzani W,

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med 2017.

60. Woznica EA, Inglot M, Woznica RK,

Liver dysfunction in sepsis. Adv Clin Exp Med 2018.

61. Brierre S, Kumari R, Deboisblanc BP.

The endocrine system during sepsis. Am J Med Sci 2004.

62. Marik PE, Zaloga GP.

Adrenal insufficiency during septic shock. Crit Care Med 2003.

63. Sharshar T, Blanchard A, Paillard M,

Circulating vasopressin levels in septic shock. Crit Care Med 2003.

65. Sonneville R, Verdonk F, Rauturier C,

Understanding brain dysfunction in sepsis. Ann Intensive Care 2013.

66. JP Carpentier, G Pouliquen, R Pétrognani.

Choc septique. Maladies infectieuses EMC 2001. 8-003-R-10, 13p.

67. Groupe transversal sepsis.

Prise en charge initiale des états septiques graves de

l’adulte et de l’enfant. Réanimation 16 (2007) S1–S21. 2006 Société de réanimation de langue française. Elsevier Masson

68. É. Wiel, O. Joulin, P. Pétillot, G. Lebuffe, B. Vallet.

État septique aigu (choc septique). Médecine d’urgence. EMC 2007. 25-090-A-10, 11p 69. J. M. Mautz, C. Bertan

choc septique. IN : Goulam. Les urgences edits 1995.195-201 70. Dhainaut J.F et Martin N.

Choc septique. EMC. Anesthésie Réanimation, 36-840- D10, 1998, 14p.

71. Luce JM.

Pathogenesis and management of sepsis shock. Chest 1987 ; 91 : 883-888 72. PA Nee, EP Rivers .

The end of the line for the Surviving Sepsis Campaign, but not for early goal-directed therapy. Emergency Medecine Journal 2011 ; Vol 28 No 1

73. Soummer, O. Langeron.

Conduite à tenir devant un état de choc. EMC-Médecine 2 (2005) 245–252.

74. Levy B, Sadoune LO, Gelot AM, Bollaert PE, Nabet P, Larcan A.

Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholaminetreated septic shock. Crit Care Med 2000; 28:114–9.

75. Christian Brun Buisson, Eric Roupie.

Choc septique : étiologie, physiopathologie, diagnostic, traitement. Rev. Prat (paris) 1995, 45: 1797-2007.

76. Mousavi N, Czarnecki A, Ahmadie R, Tielan Fang, Kumar K, Lytwyn M, et al ,

The utility of tissue Doppler imaging for the noninvasive determination of left ventricular filling pressures in patients with septic shock. J Intensive Care Med . 2010 May-Jun ; 25(3):163-7.

77. Cailes B, Vergnano S, Kortsalioudaki C, Heath P, Sharland M.

The current and future roles of neonatal infection surveillance programmes in combating antimicrobial resistance. Early Hum Dev . 2015 Sep 16. pii: S0378-3782(15)00176-0.

doi: 10.1016/j.earlhumdev.2015.08.012. [Epub ahead of print] Review.

78. Goldhaber SZ.

Pulmonary embolism. Lancet 2004; 363: 1295–305.

79. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee.

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;2:864–74.

80. EP Rivers, B N Guyen, S Haustad, J Ressler, A Muzzin, B Knoblich et al :

Early Goal Directed therapy in the treatment of Severe Sepsis and Septic Shock. New EnglandJournal of Medecine 2001 ; 345 : 1368-1377.

81. Dellinger RP, Levy MM, Carlet JM,

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36: 296–327.

82. Dellinger RP, Levy MM, Rhodes A,

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41: 580–637.

83. Rhodes A, Phillips G, Beale R,

The Surviving Sepsis Campaign bundles and outcome: Results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Med 2015;

41:1620–1628.

84. Ferrer R, Martin-Loeches I, Phillips G,

Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the

85. Dellinger RP, Schorr CA, Levy MM.

A Users’ Guide to the 2016 Surviving Sepsis Guidelines. Crit Care Med 2017;45: 381–385.

86. Levy MM, Evans LE, Rhodes A

The Surviving Sepsis Campaign bundle: 2018 update. Crit Care Med 46:997–1000 87. Leisman DE, Doerfler ME, Ward MF,

Survival benefit and cost savings from compliance with a simplified 3-hour sepsis bundle in a series of prospective, multisite, observational cohorts(2017). Crit Care Med 45:395–406

88. Ann. Fr.

Med. Urgence (2019) 9:197-199 DOI 10.3166/afmu-2019-0158 89. Annane D, Aegerter P, Jars-Guincestre MC, Guidet B.

Current epidemiology of septic shock. Am J Respir Crit Care Med 2003; 168: 165-72.

90. Brun-Buisson C.

Épidémiologie des états septiques graves.

Presse Med. 2006; 35: 513-20 © 2006, Masson, Pari.

91. Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K.

Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med. 2003; 31: 2332-8.

92. Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A et al.

The European Sepsis Group. Epidemiology of sepsis and infection in ICU patients from an international multicenter cohort study.

Intensive Care Med. 2002; 28: 108-21 (Erratum p. 526).

93. Alberti C, Brun-Buisson C, Goodman SV, Guidici D, Granton J, Moreno R et al.

Influence of Systemic Inflammatory Response Syndrome and Sepsis on Outcome of Critically Ill Infected patients.

Am J Respir Crit Care Med. 2003; 168: 77-84.

94. Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J.

Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004; 30: 589-96.

95. Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J.

Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med 2008;177:498-505.