23 Expression of ErbBs in human cancers 42
24 Different functions of nuclear EGFR 42
25 First steps of human myoblast differentiation 45
26 From muscle dissociation to myoblast differentiation 46
27 Proliferation and differentiation of myoblasts 47
28 RNAi mechanism 49
29 Model of the whole-cell patch clamp technique 50
30 Patch clamp, the whole cell configuration 51
31 Model of the Fura-2AM technique 53
32 Principle of the RTK assay 56
33 Receptor Tyrosine Kinases (RTKs) assay 58
34 Receptor Tyrosine Kinases (RTKs) assay: ErbB receptors 59 35 A/ EGFR expression at the plasma membrane ; B/ punctae of EGFR
quantification
60
36 EGFR expression 61
37 SiEGFR efficiency: EGFR expression 62
38 SiEGFR efficiency: EGFR expression at the membrane 63
39 siEGFR: effect on proliferation 64
40 Myoblast proliferation relies on the presence of EGF 65
41 siEGFR: effect on Kir2.1 hyperpolarization 66
42 siEGFR: effect on hyperpolarization-linked SOCE 67 43 siEGFR: effect on muscle specific proteins expression (5 days) 69 44 siEGFR: effect on muscle specific proteins expression (2 days) 70 45 siEGFR: chronological expression of muscle specific proteins 71
115
46 siEGFR: effect in differentiation conditions 72
47 EGFR-EGFP transfection 73
48 Vitamin K3 effects 74
49 Cell cycle arrest does not induce myoblast differentiation 75
50 Role of EGF on EGFR expression 76
51 Role of EGFR ligands (EGF, HB-EGF, TGFα) on EGFR expression 77 52 Role of EGFR ligands (EGF, HB-EGF, TGFα) on MEF2 expression 78
53 Effect of BAPTA-AM on EGFR expression 79
54 Effects of lysosomal inhibitors on EGFR expression and muscle specific proteins expression
81
55 Effects of proteasomal inhibitor (MG132) on EGFR expression, muscle
specific proteins expression and proliferation 83 56 Effects of proteasomal inhibitor (epoxomycin and lactacystin) on EGFR
expression, muscle specific proteins expression and proliferation 84 57 RD cells : expression of Ki67, MEF2, MEF2C, myogenin
(immuno-fluorescence)
86
58 RD cells : expression of EGFR, erbB2, MEF2, myogenin (western blot) 87
59 Reserve cells express EGFR 88
60 Reserve cells vs. myotubes: expression of EGFR, MEF2, myogenin, troponin, STIM1, STIM2
89
116
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