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Ici, nous avons démontré la puissance d'une approche basée sur les activations ectopiques de gènes pour trouver de nouveaux facteurs

pronostiques, améliorant ainsi notre système pronostique existant, de sorte

que les patients à haut risque, en particulier ceux qui sont actuellement cachés

au sein des groupes à faible risque, puissent être identifiés dès que possible,

afin de permettre l'augmentation de la thérapie.

Références

1. Allis CD, Reinberg D, Jenuwein T (2007) Epigenetics. Cold Spring Harbor

Laboratory Press

2. Amaar YG, Tapia B, Chen ST, Baylink DJ, Mohan S (2006) Identification and

characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a

potential regulator of osteoblast cell proliferation. Am J Physiol Cell Physiol

290: C900-6

3. Aprelikova O, Pandolfi S, Tackett S, Ferreira M, Salnikow K, Ward Y, Risinger

JI, Barrett JC, Niederhuber J (2009) Melanoma antigen-11 inhibits the

hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.

Cancer Res 69: 616-24

4. Armstrong SA, Look AT (2005) Molecular genetics of acute lymphoblastic

leukemia. J Clin Oncol 23: 6306-15

5. Aspland SE, Bendall HH, Murre C (2001) The role of E2A-PBX1 in

leukemogenesis. Oncogene 20: 5708-17

6. Ayton PM, Cleary ML (2001) Molecular mechanisms of leukemogenesis

mediated by MLL fusion proteins. Oncogene 20: 5695-707

7. Bader P, Kreyenberg H, Henze GH, Eckert C, Reising M, Willasch A, Barth A,

Borkhardt A, Peters C, Handgretinger R, Sykora KW, Holter W, Kabisch H,

Klingebiel T, von Stackelberg A (2009) Prognostic value of minimal residual

disease quantification before allogeneic stem-cell transplantation in relapsed

childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J

Clin Oncol 27: 377-84

8. Bai S, Wilson EM (2008) Epidermal-growth-factor-dependent phosphorylation

and ubiquitinylation of MAGE-11 regulates its interaction with the androgen

receptor. Mol Cell Biol 28: 1947-63

9. Balduzzi A, Valsecchi MG, Uderzo C, De Lorenzo P, Klingebiel T, Peters C,

Stary J, Felice MS, Magyarosy E, Conter V, Reiter A, Messina C, Gadner H,

Schrappe M (2005) Chemotherapy versus allogeneic transplantation for

very-high-risk childhood acute lymphoblastic leukaemia in first complete

remission: comparison by genetic randomisation in an international

prospective study. Lancet 366: 635-42

10. Bassan R, Hoelzer D (2011) Modern therapy of acute lymphoblastic leukemia.

J Clin Oncol 29: 532-43

11. Basso G, Veltroni M, Valsecchi MG, Dworzak MN, Ratei R, Silvestri D,

Benetello A, Buldini B, Maglia O, Masera G, Conter V, Arico M, Biondi A,

Gaipa G (2009) Risk of relapse of childhood acute lymphoblastic leukemia is

predicted by flow cytometric measurement of residual disease on day 15 bone

marrow. J Clin Oncol 27: 5168-74

12. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg

RA (2008) An embryonic stem cell-like gene expression signature in poorly

differentiated aggressive human tumors. Nat Genet 40: 499-507

cellular identity goes awry. Dev Cell 19: 698-711

14. Bhatia S, Landier W, Shangguan M, Hageman L, Schaible AN, Carter AR,

Hanby CL, Leisenring W, Yasui Y, Kornegay NM, Mascarenhas L, Ritchey AK,

Casillas JN, Dickens DS, Meza J, Carroll WL, Relling MV, Wong FL (2012)

Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and

non-Hispanic white children with acute lymphoblastic leukemia: a report from

the children's oncology group. J Clin Oncol 30: 2094-101

15. Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, Min DJ,

Potter JW, Harvey R, Hunger SP, Seibel N, Raetz EA, Pieters R, Horstmann

MA, Relling MV, den Boer ML, Willman CL, Carroll WL (2008) Gene

expression signatures predictive of early response and outcome in high-risk

childhood acute lymphoblastic leukemia: A Children's Oncology Group Study

[corrected]. J Clin Oncol 26: 4376-84

16. Bornkamm GW (2009) Epstein-Barr virus and the pathogenesis of Burkitt's

lymphoma: more questions than answers. Int J Cancer 124: 1745-55

17. Borowitz M, Chan J (2008) T leucémie lymphoblastique / lymphome. .

Classification OMS des tumeurs des tissus hématopoïétiques et lymphoïdes,

4th edn. IARC, Lyon, pp 176-178

18. Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard M-H, Durand P, Samarut J,

Pain B, Rouault J-P (2010) Role of miR-34c microRNA in the late steps of

spermatogenesis. RNA 16: 720-31

19. Boussouar F, Jamshidikia M, Morozumi Y, Rousseaux S, Khochbin S (2013)

Malignant genome reprogramming by ATAD2. Biochim Biophys Acta in press

20. Boussouar F, Rousseaux S, Khochbin S (2008) A new insight into male

genome reprogramming by histone variants and histone code. Cell Cycle 7:

3499-502

21. Caron C, Lestrat C, Marsal S, Escoffier E, Curtet S, Virolle V, Barbry P,

Debernardi A, Brambilla C, Brambilla E, Rousseaux S, Khochbin S (2010)

Functional characterization of ATAD2 as a new cancer/testis factor and a

predictor of poor prognosis in breast and lung cancers. Oncogene 29: 5171-81

22. Carroll WL (2013) Safety in numbers: hyperdiploidy and prognosis. Blood 121:

2374-6

23. Carroll WL, Raetz EA (2012) Clinical and laboratory biology of childhood acute

lymphoblastic leukemia. J Pediatr 160: 10-8

24. Chen B, Wang YY, Shen Y, Zhang WN, He HY, Zhu YM, Chen HM, Gu CH,

Fan X, Chen JM, Cao Q, Yang G, Jiang CL, Weng XQ, Zhang XX, Xiong SM,

Shen ZX, Jiang H, Gu LJ, Chen Z, Mi JQ, Chen SJ (2012) Newly diagnosed

acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346

childhood and adult cases and their comparison with the reports from Western

countries. Leukemia 26: 1608-16

25. Ciró M, Prosperini E, Quarto M, Grazini U, Walfridsson J, McBlane F, Nucifero

P, Pacchiana G, Capra M, Christensen J, Helin K (2009) ATAD2 is a novel

cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer

Res 69: 8491-8

26. Copelan EA, McGuire EA (1995) The biology and treatment of acute

lymphoblastic leukemia in adults. Blood 85: 1151-68

27. Cortes JE, Kantarjian H, Shah NP, Bixby D, Mauro MJ, Flinn I, O'Hare T, Hu S,

Narasimhan NI, Rivera VM, Clackson T, Turner CD, Haluska FG, Druker BJ,

Deininger MW, Talpaz M (2012) Ponatinib in refractory Philadelphia

chromosome-positive leukemias. N Engl J Med 367: 2075-88

28. Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, Hu M, Liu JS, Ren B (2012)

Topological domains in mammalian genomes identified by analysis of

chromatin interactions. Nature 485: 376-80

29. Downing JR (2003) The core-binding factor leukemias: lessons learned from

murine models. Curr Opin Genet Dev 13: 48-54

30. Doyle JM, Gao J, Wang J, Yang M, Potts PR (2010) MAGE-RING protein

complexes comprise a family of E3 ubiquitin ligases. Mol Cell 39: 963-74

31. Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM,

Capdeville R, Talpaz M (2001) Activity of a specific inhibitor of the BCR-ABL

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