A clinically used PET tubular mesh was coated with a 10 µm thick layer of PLGA, containing 40 µg of ATV per mg of mesh. The optimal release profile obtained demonstrated a fast release of 40 % of the drug over 3 days, followed by a sustained release over 40 days. The mesh was successfully coated externally with a layer of ATV-free PLCL, at the cost of an acceptable decrease of elasticity. This
CHAPTER V - Design and characterization of a perivascular PLGA coated perivascular mesh sustaining the release of atorvastatin for the prevention of restenosis.
125 mesh will be tested in an ex vivo model of human saphenous vein graft exposed to arterial pressure [12, 13]. The mesh should undergo γ-ray sterilization prior testing. The unidirectional drug release as well as the the ability of the ATV-releasing tubular prosthesis to decrease intimal hyperplasia should be further evaluated.
Credits
For this project, conception is credited to Dr. F. Delie, Dr. O. Jordan, Prof. J.-A. Haefliger, Dr. F.
Saucy and I. Mylonaki. Experimental design, data analysis and interpretation has been achieved by I. Mylonaki supervised by Dr. F. Delie, Dr O. Jordan and Prof. Allémann. Part of the data acquisition was done by and Orio Trosi, as part of his master work in pharmaceutical sciences.
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