En conclusion, l’identification des motifs rm1 et rm2 présents dans l’ARNr 18S a permis d’établir que leurs interactions avec les motifs m1 et m2 de la tige-boucle 3’ de snR30 sont essentielles à la synthèse de l’ARNr 18S et la viabilité cellulaire. Cette interaction
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essentielle entre snR30 et le pré-ARNr est conservée au cours de l’évolution et pourrait former une structure ARN guide/ARN cible totalement nouvelle pour les snoARN à boîtes H/ACA laissant la possibilité que bien d’autres ARN H/ACA orphelins utilisent les mêmes règles d’appariements. D’autre part, même s’il semble impossible d’exclure la possibilité que les motifs m1 et m2 de snR30 présentent une activité chaperonne, il semble qu’elle n’est pas suffisante pour remplir le rôle de snR30 dans la maturation du pré-ARNr. Nous avons donc proposé que snR30, via les motifs essentiels présents dans la région distale de la tige-boucle 3’, pourrait cibler ou recruter des facteurs essentiels au pré-ARNr en cours de maturation. La coexistence de ces deux mécanismes, coopérant ou non entre eux, pourrait aussi expliquer le rôle de snR30 dans les étapes de clivages du pré-ARNr.
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