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MATERIALS AND METHOD

2. Berquin Patrick, Amiens

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3. Biederman Joseph, MD; Faraone Stephen V, PhD; Monuteaux Michael C, ScD; and Grossbard Joel R, MA

How Informative Are Parent Reports of Attention-Deficit/Hyperactivity Disorder Symptoms for Assessing Outcome in Clinical Trials of Long-Acting Treatments? A Pooled Analysis of Parents’ and Teachers’ Reports

Pediatrics 2004;113;1667-1671 DOI:10.151427peds.113.6.1667 4. Greenhill Laurence

Attention-Deficit Hyperactivity Disorder: the Stimulants Child Adolesc Psychiatr Clinic North Am 1995;4:123-169

5. Markowitz John S, Pharm. D.; Straughn Arthur B, Pharm.D.; Patrick Kennerly S, Ph.D.

Advances in the Pharmacotherapy of Attention-Deficit-Hyperactivity Disorder: Focus on Methylphenidate Formulations

Pharmacotherapy Volume 23, Number 10, 2003

6. Brown Ronald T, Amler Robert W, Freeman Wendy S, Perrin James M, Stein Martin T, Feldman Heidi M, Pierce Karen, Wohlraich Mark L and the Committtee on Quality Improvement, Subcommittee on Attention-Deficit/Hyperactivity Disorder

Treatment of Attention-Deficit/Hyperactivity Disorder: Overview of the Evidence Pediatrics 2005;115;749-757

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7. Pelham William E, Gnagy Elisabeth M, Burrows-Maclean Lisa, Williams Andy, Fabiano Gregory A, Morrisey Sean M, Chronis Andrea M, Forehand Gregory L, Nguyen Celeste A, Hoffman Martin T, Lock Thomas M, Fielbelkorn Karl, Coles Erika K, Panahon Carlos J, Steiner Randi L, Meichenbaum David L, Onyango Adia N and Morse Gene D

Once-A-Day Concerta Methylphenidate Versus Three-Times-Daily Methylphenidate in Laboratory and Natural Settings

Pediatrics 2001;107:e105 DOI:10.1542/peds.107.6.e105

Conlon Charles, Pearl Phillip L, Black David O, Seymour Karen E and Newcorn Jeffrey H

A Dose-response Study of OROS Methylphenidate in Children With Attention-Deficit/Hyperactivity disorder

Pediatrics 2003;112;404-13 DOI: 10.1542/peds.112.5.e404

9. Wohlraich Mark L, Greenhill Laurence L, Pelham William, Swanson James, Wilens Timothy, Palumbo Donna, Atkins Mark, McBurnett Keith, Bukstein Oscar, August Gerald and on Behalf of the Concerta Study Group

Randomized, Controlled Trial of OROS Methylphenidate Once a day in Children With Attention Deficit/Hyperactivity disorder

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Comparison of Sustained-release and Standard Methylphenidate in the treatment of minimal brain dysfunction

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13. Sustained-release Methylphenidate: New preparations. New pharmaceutical forms: a Slight Advantage for a Small Number of Children

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14. Lopez Frank, Silva Paul, Pestreich Linda and Muniz Rafael

Comparative Efficacy of Two Once Daily Methylphenidate Formulations (Ritalin®LA and Concerta®) and Placebo in Children with Attention Deficit Hyperactivity Disorder Across the School Day

Pediatr Drugs 2003; 5 (8), 545-555

Single- and Multiple-dose Pharmacokinetics of an Oral Once-a-day Osmotic Controlled-release OROS (Methylphenidate HCl) Formulation

J Clin Pharmacology 2000;40(4):379-88

16. Brown Ronald T, Freeman Wendy S, Perrin James M, Stein Martin T, Amler Robert W, Feldman Heidi M, Pierce Karen and Wohlraich Mark L

Prevalence and Assessment of Attention-Deficit/Hyperactivity Disorder in Primary Care Settings Pediatrics 2001;107;e43

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17. Swanson JM, Lerner M, Williams L

More Frequent Diagnosis of Attention-Deficit/Hyperactivity Disorder N Engl J Med. 1195;333:944

18. Klassen Anne F, Miller Anton and Fine Stuart

Health-Related Quality of Life in Children and Adolescents Who Have a Diagnosis of Attention-Deficit/Hyperactivity Disorder

Pediatrics 2004,114,541-547 DOI:10.1542/peds.2004-0844

19. Chhabildas Nomita, Pennington Bruce F, Willcut Erik G.

A comparison of the Neuropsychological Profiles of the DSM IV Subtypes of ADHD Journal of Abnormal Child Psychology, Vol. 29, No. 6, December 2001, pp. 529-540 20. Spencer T, Biederman J, Wilens T

Attention-Deficit/Hyperactivity Disorder and Comorbidity Pediatr Clin North Am1999;46:915-927

21. Di Scala Carla, Leschier Ilana, Barthel Martha and Li Guohua Injuries to Children With Attention Deficit Hyperactivity Disorder Pediatrics 1998;102;1415-1421

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23. Wohlraich Mark L, MD; Wibbelsman Charles J, MD; Brown Charles J, PhD; Evans Steven W, PhD; Gotlieb Edward M; Knight John R, Ross Clarke E, Shubiner Howard H, Wender Esther and Wilens Timothy

Attention-Deficit/Hyperactivity Disorder among Adolescents: A Review of the Diagnose, Treatment, and Clinical Implications

Pediatrics 2005; 115; 1734-1746 DOI: 10.1542/peds.2004-1959

Methylphenidate and Cognitive Therapy: a Comparison of treatment Approaches with Hyperactive Boys

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27. Biederman Joseph, Heiligenstein John H, Faries Douglas E, Galilv, Dittemnn Ralf, Emslie Graham J, Kratochvil Christopher J, Laws Hary F and Schuh Kory J

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28. Bymaster Frank P, M.S., Katner Jason S, B.S., Nelson David L, Ph.D., Hemrick-Luecke Susan K, M.S., Threlkeld Penny G, M.S., Heiligstein John H, M.D., Morin S. Michelle, M.S., Gehlert Donald R, Ph.D., and Perry Kenneth W, M.S.

Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat: A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

Neuropsychopharmacology 2002-Vol 27, N° 5

29. Biederman Joseph, Lopez Frank A, Boellner Samuel W and Chandler Mark C

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of SLI381 (Adderall XR) in Children With Attention-Deficit/hyperactivity Disorder

Pediatrics 2002;110;258-266 DOI:10.1542/peds.110.2.258

Gregory A, Onyango Adia N, Meichenbaum David L, Williams Andy, Aronoff Helen R and Steiner Randi L

A Comparison of Morning Only and Morning/Late Afternoon Adderall to Morning-Only, Twice-Daily, Three Times-Daily Methylphenidate in Children with Attention-Deficit/Hyperactivity Disorder Pediatrics 1999;104;1300-1311

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31. Pelham William E, Aronoff Helen R, Midlam Jill K, Shapiro Cheri J, Gnagy Elisabeth M, Chronis Andrea M, Onyango Adia N, Forehand Gregory, Nguyen Anh and Waxmonsky James

A Comparison of Ritalin and Adderall: Efficacy and Time-course in Children With Attention-Deficit/Hyperactivity Disorder

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Side Effects of Methylphenidate and Dexamphetamine in Children With Attention Deficit Hyperactivity Disorder: A Double Blind, Crossover Trial

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Attention-deficit Hyperactivity Disorder: Recent Advances in Paediatric Pharmacotherapy Drugs 2010;70(1):15-40

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Attention Deficit Disorder With and Without Hyperactivity: Clinical Response to Three Dose Levels of Methylphenidate

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37. Vetter Viktoria L, MD; Ella Josephine, MD; Edckson Christopher, MD; Berger Stuart, MD; Blum Nathan, MD; Uzarh Karin, RN; Webb Catherine L,MD

Cardiovascular Monitoring of Children and Adolescents with Heart Disease Receiving Medications for Attention Deficit/Hyperactivity Disorder

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40. Spencer Thomas, Biederman Joseph and Wilens Thimothy

Growth Deficits in Children With Attention Deficit Hyperactivity Disorder Pediatrics 1998;102;501-506

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41. Sunohara Glen A, Ph.D., Malone Molly A, Ph.D., Rovet Joanne, Ph.D., Humphries Thomas, Ph.D., Roberts Wendy, M.D., and Taylor Margot J, Ph.D

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Name : First Name : Date of Birth

Date of introduction of IR : Dose of IR :

What is, according to you, the length of actin of IR ?

Compared to IR, SR seems:

- More efficient - Less efficient

- On which symptoms is it more or less efficient ?

Did teachers notice a different behaviour since introduction of SR ? If yes, which one ?

Did you notice any change in school results after introduction of SR ? If yes, which one ?

Compare SR to IR side effects - Appetite loss lunch : - Appetite loss dinner : - Sleeping disorder :

- Rebound effext afternoon : - Rebound effect evening : - Headaches :

- Abdominal pain :

Compared to IR, SR has following effects :

- more or less positive effect on attention/concentration deficit ? - more or less positive effect on impulsivity ?

- more or less positive effect on hyperactivity?

If yes, why ? If no, why ?

What does your child think about SR ?

How long has your child been under a SR trial ? What was your decision after the SR trial ?

- Keep your child under SR ? - Change dose of SR ? - A mixture of SR and IR ? - Put your child back on IR ?

Comments on SR :

Name : First Name : Date of Birth

Is ER the first medication introduced for treatment of ADHD ? If not, which treatment did he have before ?

- IR ? dose ? - SR® ? dose ? - IR + SR ? dose ?

Date of introduction of IR or SR ? Date of introduction of ER ? Actual dose of ER ?

Days of treatment of ER ? - Days of school ?

- Days of school and extrascolar activities ? - seven days a week ?

What time does your child take ER ?

Does your child have difficulties swallowing ER tablets?

After how much time does ER start acting ?

How long does ER act ?

Compared to IR or SR, does ER seem : - More efficient ?

- Less efficient ? - Same efficiency ?

What behavioural change in your child did you observe after the switch to ER?

What behavioural change in your child did teachers observe after the switch to ER?

What behavioural change did your child observe himself after the switch to ER?

Looking at behaviour, school results, relations with pairs /teachrs /family members, did ER bring any change ?

Compare side effects of ER compared to IR or SR : - Appetite loss lunch :

- Appetite loss dinner : - Sleeping disorder :

- Rebound effext afternoon : - Rebound effect evening : - Headaches :

- Abdominal pain :

Compared to IR or SR, ER is :

- more or less efficient on attention / concentration deficit ? - more or less efficient on impulsivity ?

- more or less efficient on hyperactivity ?

Are you satisfied by ER ? If yes, why ?

If no, why ?

Is your child satisfied by ER ?

How long was your child’s trial on ER ?

What did you decide after the ER trial : - Keep your child on ER ? - Change dose of ER ?

- Switch your child back to IR or SR ? - Stop any ADHD treatment ?

Comments on ER :

TABLES ET FIGURES

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