ANNEXES

Annexes :

Antibiotiques à tester sur l’antibiogramme de Staphylococcus aureus selon les recommandations du CA-SFM 2021

Penicillins Disk

content (µg)

1

S ≤ R > S ≥ R <

Note² Note² Note^C Note^C

Ampicillin,S. saprophyticus Note^2,3 Note^2,3 Ampicillin-sulbactam Note^1,2,3 Note^1,2,3 Note^A,C,D Note^A,C,D

Note^1,2,3 Note^1,2,3 Note^A,C,D Note^A,C,D

Amoxicillin-clavulanic acid Note^1,2,3 Note^1,2,3 Note^A,C,D Note^A,C,D Piperacillin Note^1,2,3 Note^1,2,3 Note^A,C,D Note^A,C,D

Note^1,2,3 Note^1,2,3 Note^A,C,D Note^A,C,D

Ticarcillin Note^1,2 Note^1,2 Note^A,C Note^A,C Ticarcillin-clavulanic acid Note^1,2 Note^1,2 Note^A,C Note^A,C

- - - - Note¹ Note¹ Note^A Note^A

-² -² Note^C Note^C

Oxacillin (screen only), S. pseudintermedius and S. schleiferi

NA NA 20^E 20^E

Oxacillin⁴,other staphylococci Note^A Note^A Cloxacillin Note^1,2 Note^1,2 Note^A,C Note^A,C Dicloxacillin Note^1,2 Note^1,2 Note^A,C Note^A,C Flucloxacillin Note^1,2 Note^1,2 Note^A,C Note^A,C

- - - -

Cephalosporins Disk content

(µg)

1

S ≤ R > S ≥ R <

Cefaclor² Note¹ Note¹ Note^A Note^A

Cefadroxil Note¹ Note¹ Note^A Note^A

Cefalexin Note¹ Note¹ Note^A Note^A

Cefazolin Note¹ Note¹ Note^A Note^A

Cefepime Note¹ Note¹ Note^A Note^A

Cefiderocol - - - -

Cefixime - - - -

Note¹ Note¹ Note^A Note^A Cefoxitin (screen only), S. aureus and

coagulase-negative staphylococci other than S. epidermidis

Cefoxitin (screen only), S. epidermidis Cefoxitin (screen only),

S. pseudintermedius and S. schleiferi

Note⁵ Note⁵ Note^C Note^C

Cefpodoxime Note¹ Note¹ Note^A Note^A

1⁶ 1⁶ 20^D 20^D - - - - - - - -

Ceftibuten - - - -

- - - -

Ceftriaxone² Note¹ Note¹ Note^A Note^A Note¹ Note¹ Note^A Note^A Cefuroxime oral Note¹ Note¹ Note^A Note^A

Carbapenems Disk content

(µg)

1

S ≤ R > S ≥ R <

Note¹ Note¹ Note^A Note^A Note¹ Note¹ Note^A Note^A Note¹ Note¹ Note^A Note^A Imipenem-relebactam Note¹ Note¹ Note^A Note^A Note¹ Note¹ Note^A Note^A Meropenem-vaborbactam Note¹ Note¹ Note^A Note^A

Monobactams Disk

content (µg)

S ≤ R > S ≥ R <

Aztreonam - - - -

Fluoroquinolones Disk

content (µg)

1

S ≤ R > S ≥ R <

Delafloxacin, S. aureus Note^B Note^B

Nalidixic acid (screen only) NA NA NA NA

NA NA Note² Note² Note^D Note^D

Aminoglycosides Disk content

(µg)

1

S ≤ R > S ≥ R <

IE IE

Glycopeptides and lipoglycopeptides Disk content

(µg)

1

S ≤ R > S ≥ R <

Dalbavancin² Note^A Note^A

Oritavancin², S. aureus Note^A Note^A Note^A Note^A

Note^A Note^A

Telavancin²,MRSA 0.125^3,5 0.125³ Note^A Note^A Note^A Note^A

Note^A Note^A

Macrolides, lincosamides and streptogramins

Disk content

(µg)

S ≤ R > S ≥ R <

Azithromycin Note^A Note^A

Clarithromycin Note^A Note^A

Erythromycin

Roxithromycin Note^A Note^A

Telithromycin IE IE

Clindamycin²

Quinupristin-dalfopristin

Tetracyclines Disk

content (µg)

S ≤ R > S ≥ R <

Note^A Note^A

Eravacycline, S. aureus

0.5¹ 0.5¹ 23^A 23^A

Oxazolidinones Disk

content (µg)

S ≤ R > S ≥ R <

Miscellaneous agents Disk content

(µg)

S ≤ R > S ≥ R <

Chloramphenicol

- - - - Note^A Note^A 32³ 32³ Note^A Note^A - - - -

Lefamulin, S. aureus

- -

- - - -

Antibiotiques à tester sur l’antibiogramme d’Entérobactéries BLSE et EPC selon les recommandations du CA-SFM avec leurs concentrations et diamètres critiques (CA-SFM, 2021)

Penicillins MIC breakpoints

(mg/L)

1 Disk

content (µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - -

Ampicillin¹ 10

Ampicillin-sulbactam¹ 10-10

- Note^B Note^B

Amoxicillin-clavulanic acid¹ 20-10 19-20

Amoxicillin-clavulanic acid (uncomplicated UTI only)

20-10

Piperacillin 30

16 30-6 19

Ticarcillin 75

Ticarcillin-clavulanic acid 75-10

30

- - - -

Oxacillin - - - -

Cloxacillin - - - -

Dicloxacillin - - - -

Flucloxacillin - - - -

8⁵ 8⁵ 10

Cephalosporins MIC breakpoints (mg/L)

1 Disk

content (µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Cefaclor - - - -

Cefadroxil (uncomplicated UTI only) 30

Cefalexin (uncomplicated UTI only) 30

Cefazolin (infections originating from the urinary tract), E. coli, and Klebsiella spp.

(except K. aerogenes)

30

Cefepime 30

Cefiderocol 30 18-22

Cefixime (uncomplicated UTI only) 5

5

5

Cefoxitin (screen only)⁴ Note⁴ Note⁴ 30

Cefpodoxime (uncomplicated UTI only)

10

5 22-23

10

10-4

Ceftibuten (infections originating from the urinary tract)

30

5

30-10 19-21

Ceftriaxone (indications other than meningitis)

30

Ceftriaxone (meningitis) 30

30

Carbapenems¹ MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

10 10

10

10 Imipenem-relebactam, Enterobacterales

except Morganellaceae

10-25

10

10

Meropenem-vaborbactam IP IP IP

Monobactams MIC breakpoints

(mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Aztreonam¹ 30

Fluoroquinolones MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

0.5 5 22-24

Note^A Note^A Pefloxacin (screen only)^1,2 NA

Salmonella spp.

NA 5

Delafloxacin, E. coli Note^D Note^D

5 5

Nalidixic acid (screen only) NA NA NA NA

10 5

Aminoglycosides^1,2 MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

30

30

10

10

10

10

Glycopeptides and lipoglycopeptides MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Dalbavancin - - - -

Oritavancin - - - -

- - - -

Telavancin - - - -

- - - -

Macrolides, lincosamides and streptogramins

MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Azithromycin¹ - - - -

Clarithromycin - - - -

Erythromycin - - - -

Roxithromycin - - - -

Tetracyclines MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - -

Eravacycline, E. coli 20

- - - - - - - - 15

Oxazolidinones MIC breakpoints

(mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - - - - - -

Miscellaneous agents MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Chloramphenicol 30

Note^A Note^A - - - - 200^B

200^B - - - -

Lefamulin - - - -

- - - -

100

30

- - - - - - - -

5

1.25-23.75

Antibiotiques à tester sur l’antibiogramme d’A.baumannii selon les recommandations du CA-SFM avec leurs concentrations et diamètres critiques (CA-CA-SFM, 2021)

Penicillins MIC breakpoints (mg/L)

1 Disk

content (µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - -

Ampicillin - - - -

Ampicillin-sulbactam IE IE

- - - -

Amoxicillin-clavulanic acid - - - -

Piperacillin IE IE

IE IE

Ticarcillin IE IE

Ticarcillin-clavulanic acid IE IE

- - - - - - - -

Oxacillin - - - -

Cloxacillin - - - -

Dicloxacillin - - - -

Flucloxacillin - - - -

- - - -

Cephalosporins MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Cefaclor - - - -

Cefadroxil - - - -

Cefalexin - - - -

Cefazolin - - - -

- - - - - - - -

Ceftibuten - - - -

- - - - - - - -

Ceftriaxone - - - -

- - - -

Cefuroxime oral - - - -

Carbapenems MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

10 - - - - 10

Imipenem-relebactam² 10-25

10

10 Meropenem-vaborbactam² Note² Note² Note^A Note^A

Monobactams MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Aztreonam - - - -

Fluoroquinolones MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

5

Delafloxacin IE IE

5 - - - -

Nalidixic acid (screen only) NA NA NA NA

- - - -

- - - -

Aminoglycosides MIC breakpoints (mg/L)

1 Disk

content (µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

30

30

10

10

IE IE 10

10

Glycopeptides and lipoglycopeptides

MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Dalbavancin - - - -

Oritavancin - - - -

- - - -

Telavancin - - - -

- - - -

Macrolides, lincosamides and streptogramins

MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Azithromycin - - - -

Clarithromycin - - - -

Tetracyclines MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - -

Eravacycline IE IE

IE IE - - - - IE IE

Oxazolidinones MIC breakpoints (mg/L)

Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - - - - - -

Miscellaneous agents MIC breakpoints (mg/L) Disk content

(µg)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Chloramphenicol - - - -

Note^A Note^A - - - - - - - - - - - - - - - -

Lefamulin - - - -

- - - -

- - - -

- - - -

- - - - - - - -

- - - -

1.25-23.75

Antibiotiques à tester sur l’antibiogramme de Pseudomonas aeruginosa selon les recommandations du CA-SFM avec leurs concentrations et diamètres critiques (CA-SFM, 2021)

Penicillins MIC breakpoints (mg/L)

Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

- - - -

Ampicillin - - - -

Ampicillin-sulbactam - - - -

- - - - Amoxicillin-clavulanic

acid

- - - -

Piperacillin 18-19

18-19

Ticarcillin

Ticarcillin-clavulanic acid

- - - - - - - -

Oxacillin - - - -

Cloxacillin - - - -

Dicloxacillin - - - -

Flucloxacillin - - - -

- - - -

Cephalosporins MIC breakpoints (mg/L) Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

Cefaclor - - - -

Cefadroxil - - - -

Cefalexin - - - -

Cefazolin - - - -

Cefepime

Cefiderocol, P.

aeruginosa

14-22

Cefixime - - - -

- - - -

Cefoxitin - - - -

Cefpodoxime - - - -

- - - -

16-17

Ceftibuten - - - -

IE IE IE IE

Ceftriaxone - - - -

- - - -

Cefuroxime oral - - - -

Carbapenems MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

- - - - Imipenem-relebactam,

P. aeruginosa

Meropenem-vaborbactam, P. aeruginosa

IP IP

Monobactams MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

Aztreonam

Fluoroquinolones MIC breakpoints (mg/L) Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

Delafloxacin IE IE

- - - - Nalidixic acid (screen

only)

NA NA NA NA

- - - -

Aminoglycosides^P1 MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

IE IE

IE IE

IE IE

Glycopeptides and lipoglycopeptides

MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU

Dalbavancin - - - -

Oritavancin - - - -

- - - -

Telavancin - - - -

- - - -

Macrolides, lincosamides and

streptogramins

MIC breakpoints (mg/L) Zone diameter breakpoints (mm)

S ≤ R > ATU S ≥ R < ATU

Azithromycin - - - -

Clarithromycin - - - -

Erythromycin - - - -

Roxithromycin - - - -

Telithromycin - - - -

Clindamycin - - - -

Quinupristin-dalfopristin

- - - -

Tetracyclines MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU - - - -

Eravacycline - - - -

- - - - - - - - - - - -

Oxazolidinones MIC breakpoints (mg/L)

Zone diameter breakpoints (mm) S ≤ R > ATU S ≥ R < ATU - - - -

- - - -

Dans le document Place de la tigécycline dans le traitement des infections à bactéries multirésistantes (Page 106-127)