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[PDF] Top 20 Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels

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Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels

Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels

... tion of the necessary association with other subunits to form a homomeric ...Analysis of the pH sensor of ASICs is complicated by the absence of other modes of activation, such as ... Voir le document complet

8

Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

... 2 are primarily expressed in the central nervous system, while almost all subunits (except ASIC4) are expressed in sensory neurons of the peripheral nervous system(Noël et ...group of ... Voir le document complet

47

Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis

Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis

... anxiety and depression ...responses and chronic pain. Here, we investigated the role of Acid- Sensing Ion Channels 1a within the basolateral amygdala (BLA), in pain ... Voir le document complet

13

Anti-allodynic effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic migraine
in rodents

Anti-allodynic effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic migraine in rodents

... 80% of rat dural afferents trigger action potentials at ...pH7.0 and 30% at ...cephalic and extra-cephalic allodynia, which is maximal after 2 hours and inhibited by amiloride but not ... Voir le document complet

41

Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain

Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain

... Effect of i.v. Mamb-1 (0.34 nmole/mouse) and morphine ...(carrageenan 2%, 2h) determined using the von Frey ...number of paw lifts out of five mechanical stimulations with a ...Effect ... Voir le document complet

27

Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat Acid-Sensing Ion Channel 1a

Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat Acid-Sensing Ion Channel 1a

... inhibition of rASIC1a and cASIC1. A) Mamb-1 and its variants listed in descending order according to the IC 50 value on rASIC1a (boxed data from this study; other data from Mourier et ...Inhibition ... Voir le document complet

54

Acid-sensing ion channels in postoperative pain.

Acid-sensing ion channels in postoperative pain.

... ASIC3-containing channels are particularly well suited to de- tect local changes in pH associated with postoperative pain and to contribute to nociceptor sensitization: (1) they exhibit the high- est ... Voir le document complet

8

Impact of He and H relative depth distributions on the result of sequential He+ and H+ ion implantation and annealing in silicon

Impact of He and H relative depth distributions on the result of sequential He+ and H+ ion implantation and annealing in silicon

... platelets and micro-cracks. In such a case, about half of the He and H implanted fluences participate in the pressurization of the ...rest of the implanted fluen- ces is most ... Voir le document complet

11

The Dissociative Electroionization of C2H2, C2D2 and C2HD. Investigation of the [C2H(D)]+ and [H(D)]+ Dissociation Channels. The (D)H-C2H(D) binding energy.

The Dissociative Electroionization of C2H2, C2D2 and C2HD. Investigation of the [C2H(D)]+ and [H(D)]+ Dissociation Channels. The (D)H-C2H(D) binding energy.

... excitation of the C 2 H ...So and Richards [62] obtained the first excited state at ...Largo and Barrientos determined the first excitation energy to be between ...0.11 and 0.37 ... Voir le document complet

22

Ground-based remote sensing of HDO/H<sub>2</sub>O ratio profiles: introduction and validation of an innovative retrieval approach

Ground-based remote sensing of HDO/H<sub>2</sub>O ratio profiles: introduction and validation of an innovative retrieval approach

... amount, and n the number of mea- ...assumptions are correct it has no mean ...value are overesti- mated and the δD values above the a-priori value are underes- ...constraint ... Voir le document complet

19

The Dissociative Electroionization of Ammonia and Ammonia-d3. II. The H+ and H2+ Dissociation Channels.

The Dissociative Electroionization of Ammonia and Ammonia-d3. II. The H+ and H2+ Dissociation Channels.

... results and those obtained for high Ryd- berg H(Rydb.) atoms and excited H*(n) atoms ...position of the abovementioned features, the present H + and D + translational ... Voir le document complet

17

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

... Department of Physiology, Kazan State Medical University, Kazan, Russia Niflumic acid (NFA) is a member of the fenamate class of nonsteroidal anti-inflammatory ...compound and its ... Voir le document complet

18

Autism throughout genetics: Perusal of the implication of ion channels

Autism throughout genetics: Perusal of the implication of ion channels

... GRIN2B) and GABAergic (e.g., GABRA3 and GABRB3) neurotrans- mission, neuronal connection ...CNTNAP2) and ion permeabil- ity (e.g., CACNA1, CACNA2D3, and SCN1A), as well as proteins ... Voir le document complet

19

Ion Channels as Promising Therapeutic Targets for Melanoma

Ion Channels as Promising Therapeutic Targets for Melanoma

... as ion channel regulatory partners in cancer cells Targeting ion channels abnormally expressed in cancer cells represents an exciting new perspective for cancer ...these ion channels ... Voir le document complet

33

The role of ammonia in sulfuric acid ion induced nucleation

The role of ammonia in sulfuric acid ion induced nucleation

... Table 2 can not be directly used to explain the nucleation-enhancing effect of, ...concentration of each molecular species in the atmosphere through the law of mass action as shown in ...set ... Voir le document complet

10

Raman study of As outgassing and damage induced by ion implantation in Zn-doped GaAs

Raman study of As outgassing and damage induced by ion implantation in Zn-doped GaAs

... vibration of the carrier plasma which couples with the LO phonon via the macroscopic electric field to form a phonon- like LO phonon-plasmon coupling (LOPC) ...function of different carbon, 7 silicon, 8 ... Voir le document complet

5

Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

... P2X1 -/- neutrophils was not impaired under these conditions. Time-lapse videomicroscopy revealed that collagen IV-adhered P2X1 -/- neutrophils oriented better in a gradient of W- peptide but covered shorter ... Voir le document complet

1

Seasonal and interannual variations of H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; on Mars

Seasonal and interannual variations of H<sub>2</sub>O<sub>2</sub> on Mars

... time of the first H 2 O 2 detection by Clancy et ...absence of detection by TEXES in 2001 (Ls = 110°) might be due to the fact that the height of the hygropause is known to be ... Voir le document complet

3

Satellite studies of N/D-2/ emission and ion chemistry in aurorae

Satellite studies of N/D-2/ emission and ion chemistry in aurorae

... The model has been previously applied to mid-latitude calcu- lations of odd nitrogen and ion densities in the thermosphere, for comparison to satellite data [Rusch et al., 1977; Cra[r] ... Voir le document complet

6

Fast H isotope and impurity mixing in Ion-Temperature-Gradient turbulence

Fast H isotope and impurity mixing in Ion-Temperature-Gradient turbulence

... frequency and parallel dynamics ...authors are grateful for discussions with ...work of the EUROfusion Consortium and has received funding from the Euratom research and training pro- ... Voir le document complet

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