Top PDF Voltage-gated sodium channels: new targets in cancer therapy?
Voltage-gated sodium channels: new targets in cancer therapy?
... death in the world and as such represent a major problem of public ...involved in a better understanding of the etiologies of the ...improvement in the early detection of tumours in order to ...
38
Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels
... of new analgesics is ...ion channels are confined to primary afferent neurons where they likely contribute to the detection and transmission of different kinds of nociceptive ...Cav3.2 in touch/pain ...
2
Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels
... effects in different genes are associated with specific ...example, in SCN5A, LOF variants can cause Brugada syndrome, whereas GOF variants can lead to Long QT syndrome (Kroncke et ...displayed in ...
48
Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines.
... involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic ...process. In this ...
25
Voltage-gated ion channels and gating modifier toxins.
... The Voltage-Gated Ion Channels Electrical signals control contraction of muscle, secretion of hormones, sensation of the environment, processing of information in the brain, and output from ...
17
Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.
... Insect voltage-gated sodium (Na v ) channels are formed by a well-known pore-forming a -subunit encoded by para -like gene and ancillary subunits related to TipE from the mutation ...
17
Ion Channels as Promising Therapeutic Targets for Melanoma
... 3.2 Voltage-gated potassium channels and Eag1 Voltage gated K + channels (VGKC) represent the largest ion channel ...Functional channels result from the association of ...
33
Voltage-gated sodium channels assemble and gate as dimers
... displayed in a pig transgenic model a DN effect with the truncated E555X mutant channel found in a BrS ...is in accordance with our work inves- tigating a C-terminus truncated mutant (R1860fs12X) ...
15
Pyrethroids differentially alter voltage-gated sodium channels from the honeybee central olfactory neurons
... (ALNs) in cell culture. In these neurons, the voltage-dependent sodium currents are characterized by negative potential for activation, fast kinetics of activation and inactivation, and the ...
10
Intracellular galectins in cancer cells: Potential new targets for therapy (Review)
... involved in cancer was published more than 25 years ago when it was observed that they were differently regulated in normal and cancer ...galectins in cancer and excellent ...
14
Intracellular galectins in cancer cells: potential new targets for therapy (Review).
... role in cancer, considerable efforts have been directed towards the devel- opment of carbohydrate-based inhibitors that would limit the binding of galectins to glycosylated residues on cell surface ...
15
Modulation of voltage-gated potassium channels by phosphatidylinositol-4,5-bisphosphate
... ion channels in specific conformations when resolving a high- resolution ...of voltage-gated ion channels are the technical difficulties associated with the simultaneous and vectorial ...
240
Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides
... changes in some gating parameters affecting the efficiency, but not the affinity of the drug, or affect, via long-distance allosteric mechanisms the binding ...modified channels is the traditional way of ...
13
Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas
... In the softshell clam, Mya arenaria, on the eastern coast of North America, two populations were studied by Bricelj et ...accumulation in resistant populations of softshell clams exposed to Alexandrium ...
24
Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells
... event in RCCs in control conditions ...events in both control conditions or during burst firing induced by ...diffuse in the cell in order to trigger most of the exocytotic ...secretion ...
47
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
... Since in hNa V ...one. In order to keep the same expression level of the channel, we needed to keep the same total DNA quantity in all ...increase in current density when DI-S4-S5 L (+3) and ...
19
Widespread Mutations in Voltage-Gated Sodium Channel Gene of Cimex lectularius (Hemiptera: Cimicidae) Populations in Paris
... 2019, in collaboration with the public health department of Paris municipality, providing a preliminary list of potential infested locations in various geographic areas of Paris (see Figure 1 ...). ...
9
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin
... residues in voltage-sensor trapping and ß-scorpion toxin action - Mutations of the positively charged and hydrophobic amino acid residues in the IIS4 segment do not alter the binding affinity of Css ...
27
Are integrins still practicable targets for anti-cancer therapy?
... 7.5. Did We Perform the Wrong Clinical Trials? A number of clinical trials were performed for over a decade, investigating either competitive peptide-based inhibitors or monoclonal antibodies targeting specific integrins ...
30
Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding
... human voltage-gated sodium channels Na v ...1.8 in resting, active, and fast-inactivated ...binding. In sodium channels sensitive to tetrodotoxin block, the ...
10