[PDF] Top 20 Voltage-gated ion channels and gating modifier toxins.
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Voltage-gated ion channels and gating modifier toxins.
... K channels would then resemble the Na and Ca channels in having an associated subunit with a single transmembrane V V V segment and short intracellular and extracellular ...of ... Voir le document complet
17
Voltage- and cold-dependent gating of single TRPM8 ion channels
... and also provided reasonable descriptions of the single- channel kinetics and macroscopic current kinetics over a wide range of voltages ...tier and five open states on the bottom tier, with an ... Voir le document complet
24
Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
... 2003)) and then refined to a more precise model in 2011 (PDB code 2KNI, (Saez et ...loops and a compact disulfide bonded core ...spider and cone snail toxins acting on ... Voir le document complet
43
Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels
... sodium channels (Nav) are molecular targets of clinically used drugs for treatments of various diseases (epilepsy, chronic pain, cardiac arrhythmia…) and also of numerous animal and plant neuro- ... Voir le document complet
2
Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
... Acid-sensing ion channels are directly modulated by a variety of compounds of synthetic, endogenous and natural ...ASIC channels is amiloride, which is not selective but is in clinical use ... Voir le document complet
47
Toxins and Ion transfers
... ASIC3-containing channels Tissue acidosis is commonly associated with pain and is a factor found in inflammation, ischemia, fractures, haematomas, tumour development, or muscle incisions like for instance ... Voir le document complet
181
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin
... of voltage sensing has been proposed, in which the S1-S4 voltage sensor structure lies separate from the core of the channel protein along the intracellular surface of the membrane in the resting state ... Voir le document complet
27
Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas
... Nav channels are large and complex transmembrane proteins responsible for electrical excitability of cells [ 5 ...potentials and electrical conduction [ 6 ]. Nav channels are composed of a ... Voir le document complet
24
Ion Channels as Promising Therapeutic Targets for Melanoma
... 3.2 Voltage-gated potassium channels and Eag1 Voltage gated K + channels (VGKC) represent the largest ion channel ...Functional channels result from the ... Voir le document complet
33
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
... data and with known ligations in other regulatory heme proteins ...adjacent and potentially highly mobile Cap domain ...(25), and movements of the Cap domain might affect the conformations of the ... Voir le document complet
17
Differential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin
... 424 H. Le Corronc et al. / Journal of Insect Physiology 48 (2002) 419–431 Fig. 4. Pharmacological effects of fipronil on the biphasic hyperpolarization induced by pressure application (2 min duration) of 10 ⫺2 moll ⫺1 ... Voir le document complet
13
Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels
... Kir3.1 and Kir3.4 I started with a small batch of positions and introduced cysteine mutations in the wild-types ...currents and the normalized currents (with respect to the basal activity) recorded ... Voir le document complet
297
Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.
... internalization and degradation of N-type voltage-gated calcium channels: Role of the α2/δ ...morphology and is associated with the expression of a truncated α 2 δ -2 protein with ... Voir le document complet
26
Ion channels in death and differentiation of prostate cancer cells.
... malignant and non-malignant tissue specimens has been detected 81 ...(BPH) and PCa tissues is also obvious at protein level (figure ...overexpression and overactivity in circumscribed, ... Voir le document complet
31
Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels
... K2P channels. Two- pore domain potassium (K2P) channels were first identified in the genomes of yeast and ...K2P channels share this basic topology, their amino acid sequences have diverged ... Voir le document complet
14
Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis
... deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private research ... Voir le document complet
45
Acid-sensing ion channels in postoperative pain.
... ASIC3-containing channels are particularly well suited to de- tect local changes in pH associated with postoperative pain and to contribute to nociceptor sensitization: (1) they exhibit the high- est ... Voir le document complet
8
Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.
... its association with a transcription factor. It is likely that β 4 may interact with different transcription factors depending on the cell type and/or its association with other protein partners. Similarly, the ... Voir le document complet
16
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block
... France; and i Centre Hospitalier Universitaire Nantes, F-44007 Nantes, France Edited by William ...WA, and approved December 29, 2015 (received for review August 31, 2015) Dysfunction of pacemaker activity ... Voir le document complet
11
Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
... compound and its derivatives are used worldwide clinically for the relief of chronic and acute ...of voltage-gated chloride ...recordings and molecular modeling, we analyzed the action ... Voir le document complet
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