[PDF] Top 20 Thymus, central T cell self-tolerance and type 1 diabetes
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Thymus, central T cell self-tolerance and type 1 diabetes
... more and more evidence that the intrathymic expression of tissue-specific self-anti- gens plays a prominent role in the establishment of immunological ...the central immunological ... Voir le document complet
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Development of a negative self-vaccine against type 1 diabetes based on central tolerogenic properties of the thymus
... TCR Self-antigens IGF-2, GAD67 In the thymus SELF-TOLERANCE TO β CELLS Clonal deletion and anergy of self-reactive T cells Generation of specific tTreg - = « Altered » self I[r] ... Voir le document complet
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Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance
... immune tolerance 兩 immunotherapy 兩 regulatory T cells 兩 Foxp3 T he treatment of human autoimmune diseases is particularly ...sclerosis, and type 1 diabetes (T1D) are mainly chronic ... Voir le document complet
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Pathophysiology of type 2 diabetes.
... of type 2 diabetic patients are over- weight, and obesity undoubtedly plays a major role in the development of the disease (1-3, ...the central subcutaneous fat depot is the major factor ... Voir le document complet
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The central role of the thymus in the programming of immunological tolerance to neuroendocrine self: Implications for the pathogenesis of autoimmune diseases.
... neuroendocrine self-peptides in the thymus (APECED/APS-1, Graves’ disease, Down syndrome, BB rat, ...‘forbidden’ self-reactive effector T cells ... Voir le document complet
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Thymic expression of neuroendocrine self-peptide precursors: role in T-cell survival and self-tolerance
... the thymus. they play an important role in embryonic development and Active immunization against the hormone X 1 implies that some antigenic ...the self-antigen X which is highly tolerated ... Voir le document complet
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Thymic crosstalk coordinates medulla organization and T-cell tolerance induction
... T-Cell Tolerance Medullary thymic epithelial cells play a privileged role in the induction of central T-cell tolerance through their ability to express a broad range of ... Voir le document complet
14
Virus infections in pathogenesis of type 1 diabetes
... the thymus (Fig. 1) A novel type of mechanism was recently identi- fied and might intervene in intimate conjunction with a bystander effect to explain the relation- ship between CVB4 infection ... Voir le document complet
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The thymus in 2013: from a 'vestigial' organ to immunological self-tolerance and autoimmunity
... the thymus and the primary role of a thymus dysfunction in the development of autoimmune endocrine ...the thymus generates naïve T cells that are self-tolerant and competent ... Voir le document complet
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Absence of protective effect of oral insulin on residual ß-cell function in type 1 diabetes
... Oral tolerance has been shown to work in some animal models of human autoimmune dis- eases [2]; recent studies have deciphered a num- ber of cellular and molecular mechanisms underlying mucosal ... Voir le document complet
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Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes.
... Humoral and cellular immune responses of T1D The discovery of autoantibodies directed against Lan- gerhans’ islet cells was a crucial step for further demon- strating the autoimmune nature of the pathogenic ... Voir le document complet
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The thymus and the science of Self
... ment and other clinical trials based on insulin tolerization in- fluenced the course of T1D and protected the residual β cells mass from the diabetogenic autoimmune response over ...novel type of ... Voir le document complet
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Role of Checkpoint Inhibitory Molecules in the development of Type 1 Diabetes
... antigens and initiates the immune reaction towards other β-cells, resulting in ongoing inflammation of islets and eventually clinical manifestations of ...DCs and macrophages uptake these ... Voir le document complet
73
Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice
... presenting cell; tolerance; Tet-ON system; antigen presentation ...iron, and carbon monoxide (CO). In contrast to the two other isoforms, HO-1 is the only one which is induced by oxidative ... Voir le document complet
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Presentation of neuroendocrine self in the thymus: toward a novel type of vaccine/immunotherapy
... neurohypophysial and tachykinin genes, another model was proposed to explain at the molecular level the paradox of thymus ...(OT) and neurokinin A (NKA) are expressed in TEC/TNC as the dominant ... Voir le document complet
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Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT cell stimulation : role of suppressive macrophages
... produce and secrete insulin and once 80– 90% of the β-cells have been destroyed, insulin production becomes insufficient, resulting in ...age and accounts for 1–5% of all diabetes ... Voir le document complet
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Thymus dysfunction in the development of type 1 diabetes and endocrine autoimmune diseases
... species and invertebrates, the foundations of the neuroendocrine and immune systems have co-existed until now without any apparent ...(BCR) and T-cell receptor (TCR) for ...structures ... Voir le document complet
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Thymus-dependent T cell tolerance of neuroendocrine functions - Principles, reflections, and implications for tolerogenic/negative self-vaccination
... NEUROENDOCRINE SELF From the investigation of the intrathymic expression of neuroendocrine- related self-peptide precursor genes, a series of specificities could be listed to define the nature of ... Voir le document complet
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Thymic neuroendocrine self-antigens. Role in T-cell development and central T-cell self-tolerance
... in diabetes-prone BB ...the thymus of 11/15 diabetes-prone BB rats, but were clearly identified in the thymus of 15/15 diabetes-resistant BB ...the diabetes-prone BB rat. The ... Voir le document complet
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Thymus and Type 1 diabetes: Where are we now?
... about thymus physiology. • T-cell differentiation in the ...of central immunological self-tolerance. • A primary thymus defect in the development of organ-specific ... Voir le document complet
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