[PDF] Top 20 The Wnt/beta-catenin pathway in adrenocortical development and cancer
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The Wnt/beta-catenin pathway in adrenocortical development and cancer
... observed in the nuclei of neoplastic cells that accumulate in the adrenal cortex of gonadectomized inbred mice, suggesting that the Wnt signaling pathway may participate ... Voir le document complet
21
MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β-catenin and Wnt signaling
... is the most common pediatric liver cancer. In this malignant neoplasm, beta-catenin protein accumu- lates and increases Wnt signaling due to recurrent activating mutations ... Voir le document complet
17
WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production
... aplasia in late development, which pre- cludes analysis of postnatal adrenal function ( 46 ...differentiation and lower plasma aldosterone concentration at ...expression and cor- ticosterone ... Voir le document complet
17
Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.
... with the reorganization of the E-cad-herin/β-catenin ...breast cancer cells (MDA- MB-231, BT549 and Hs578T), which do not express E-cadherin but was not produced by noninvasive breast ... Voir le document complet
14
Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells
... emphasizing the importance of the cellular context, we observed that the transfection of TCF-4 alone led to an upregulation of the MCP-1 promoter activity in the BT549 and ... Voir le document complet
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en fr Role of cAMP/PKA and Wnt/beta-catenin signaling pathways in the occurrence of aberrant regulatory systems within the adrenal cortex Rôle des voies de signalisation AMPc/PKA et Wnt/bêta-caténine dans la formation des systèmes de régulation aberrants au sein de la corticosurrénale
... of the ZG under the influence of high ACTH levels, as previously proposed in animal models ...(14,15). The fact that 5-HT 4 R labelling was particularly intense in adrenocortical ... Voir le document complet
269
Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
... The Wnt/b-catenin pathway is essential for embryonic development and cell renewal, but its ectopic constitutive acti- vation is associated with cancer development ... Voir le document complet
16
New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?
... is the epithelial-mesenchymal transition (EMT)-like multi-step process, based on a transformation from an epithelial to a mesenchymal phenotype, promoting the invasive capacities of cancer ...of ... Voir le document complet
23
Crosstalk between Beta-Catenin and Snail in the Induction of Epithelial to Mesenchymal Transition in Hepatocarcinoma: Role of the ERK1/2 Pathway
... Activates the Wnt/β-Catenin Signaling Pathway β-catenin signaling requires stabilization of the cytoplasmic component of β-catenin, which then enters in nucleus, ... Voir le document complet
26
Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis.
... The Notch pathway is also known to be involved in the control of cell fate choice between proliferation and differenti- ation in intestinal epithelial lineages, and thus ... Voir le document complet
13
Characterization of p120-catenin, a novel RSK substrate in the Ras/MAPK signalling pathway
... the plasma membrane. SOS is best known for catalyzing the exchange of GDP for GTP bound to Ras, leading to its ...with, and promotes the dimerization, of Raf protein kinases (A-, B- ... Voir le document complet
103
Decoding Dishevelled-Mediated Wnt Signaling in Vertebrate Early Development
... to the third intracellular loop of Frizzled receptors and stabilizes Frizzled-Dvl interaction in Wnt/ß-catenin signaling (Tauriello et ...Moreover, the last 3 residues represent ... Voir le document complet
18
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
... of the TGFβ Signaling in CCA The importance of the TGFβ signaling in CCA renders this pathway a promising target for developing anti-tumor ...target the TGFβ ... Voir le document complet
18
Adrenocortical Cancer and IGF2: Is the Game Over or Our Experimental Models Limited?
... Constitutive Wnt/ -catenin pathway activation is the second most frequent molecular alteration in adrenal cor- tex tumors (reviewed in ...quencies in benign (51% [13]) ... Voir le document complet
3
en fr Convergence of the wnt, fgf and tgf-beta signaling pathways at the levels of the transcription factors smad1 and smad4 Convergence des voies de signalisation wnt, fgf et tgf-beta au niveau des facteurs de transcription smad1 et smad4.
... patterning and Wnt signaling The main determinant of the A–P axis in the early embryo is provided by Wnt signaling (Niehrs, 2004; Kiecker and Niehrs, ...A ... Voir le document complet
256
Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
... (JQ1 and I-BET151) of bromodomain and extraterminal family members block cell proliferation of leukemia cell ...with the recruitment of SEC to chromatin from key cancer-related genes such as ... Voir le document complet
11
Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
... of Wnt/βcatenin target genes in adrenocortical ...expression and that might also be Wnt/ β-catenin targets, we performed Pearson's r correlation tests with expression data sets ... Voir le document complet
10
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain
... injury and predict outcome. Also, we wish to highlight that changes to the grey matter are also evident in preterm born infants, including changes in cortical microstructure(Ball et ...2019) ... Voir le document complet
70
A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway
... Finding Wnt Inhibitors regulated by the Wnt/ β-catenin ...pathway. In the present study, we demonstrate that the destabilizers of the TCF/ β-catenin ... Voir le document complet
4
TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/beta-catenin signaling.
... here the impact of pathogens associated molecular patterns (PAMPS) on AEC remodeling during TGF-β ...ng/ml). The in- flammatory response as well as the remodeling process engaged were ...for ... Voir le document complet
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