[PDF] Top 20 The thymus and the science of Self
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The thymus and the science of Self
... course of the study, it remains unknown whether this treat- ment and other clinical trials based on insulin tolerization in- fluenced the course of T1D and protected the ... Voir le document complet
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The thymus in 2013: from a 'vestigial' organ to immunological self-tolerance and autoimmunity
... Abstract The programming of ‘neuroendocrine self’ occurs in the thymus, a cross-talk organ the emergence of which some 450 millions years ago allowed an integrated ... Voir le document complet
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The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the immune and neuroendocrine systems.
... Emergence of the thymus in evolution In all living species, the neuroendocrine and in- nate immune systems have evolved in parallel and still coexist today without any problem ... Voir le document complet
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The presentation of neuroendocrine self in the thymus: a necessity for an integrated evolution of the adaptive immune response and the neuroendocrine system.
... cells. The immune response is not autonomous but also regulated by central and peripheral nervous system, as well as by neuropeptides, vitamin D and neuroendocrine axes such as the ... Voir le document complet
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The presentation of neuroendocrine self-peptides in the thymus: An essential event for individual life and vertebrate survival
... Since the foundation of immunology at the end of the 19th century, prediction of autotoxic- ity/autoimmunity has been intimately associated with the discovery of ... Voir le document complet
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Programming of neuroendocrine self in the thymus and its defect in neuroendocrine autoimmunity
... are self-peptides synthesized in TECs, we hypoth- esized a processing of the thymic OT precursor that would be related to antigen presentation rather than classical neurosecre- ...with the ... Voir le document complet
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Cryptocrine Signaling in the Thymus Network and T Cell Education to Neuroendocrine Self-Antigens
... If a defect exists in the molecular mechanisms ruling intrathymic presentation of neuroendocrine self-antigens, self-reactive or intolerant T cells would migrate continu- ously f[r] ... Voir le document complet
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Development of a negative self-vaccine against type 1 diabetes based on central tolerogenic properties of the thymus
... TCR Self-antigens IGF-2, GAD67 In the thymus SELF-TOLERANCE TO β CELLS Clonal deletion and anergy of self-reactive T cells Generation of specific tTreg - = « Altered » self I[r] ... Voir le document complet
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A science-gateway workload archive application to the self-healing of workflow incidents
... (CDF) of characteristics of batched and non-batched submissions: BoT sizes, duration per BoT, inter-arrival time and consumed CPU ...workflow self-healing Distributed computing ... Voir le document complet
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Programing of the autoimmune diabetogenic response in the thymus during fetal and perinatal life
... cultures of human TECs, which resulted in an increase in the secretion of the cytokines IL-6, LIF, and GM-CSF in the supernatants ...were the principal target cells ... Voir le document complet
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The thymus as an obligatory intersection between the immune and neuroendocrine systems: pharmacological implications
... formulated the hypothesis that immune cells could express receptors susceptible to react against normal components of the ...that the organism should deploy specific mech- anisms to escape ... Voir le document complet
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Thymus-dependent T cell tolerance of neuroendocrine functions - Principles, reflections, and implications for tolerogenic/negative self-vaccination
... University of Li`ege, Center of Immunology (CIL), B-4000 Li`ege-Sart Tilman, Belgium A BSTRACT : Under the evolutionary pressure exerted by the emergence of adaptive immunity and ... Voir le document complet
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Characterization of the Insulin-Like Growth Factor Axis in the Human Thymus
... analyses of IGFBPs and IGF-1R mRNAs in human TEC primary cultures, Jurkat T-cell line and human liver or placenta as positive ...mg of total cellular RNA from TEC and Jurkat, and ... Voir le document complet
6
Thymus and T cells
... immunity and is responsible for the random generation of the huge diversity of immune receptors able to recognize infectious ...antigens. The emergence of this novel form ... Voir le document complet
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Thymus dysfunction in the development of type 1 diabetes and endocrine autoimmune diseases
... Centre of Immunoendocrinology, Institute of Pathology CHU-B23, B-4000 Liège-Sart Tilman, ...species and invertebrates, the foundations of the neuroendocrine and immune ... Voir le document complet
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The appearance of the thymus and the integrated evolution of adaptive immune and neuroendocrine systems
... concept and predic- tion of ‘horror autotoxicus’, novel structures and mechanisms appeared with a specific function in the setting-up of immu- nological ...self-tolerance. ... Voir le document complet
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Thyroid and the thymus
... Enrichment of T-cell repertoire with ‘forbidden’ self-reactive T cells ...selection of nTreg with specificity TSA. Bridge between self-reactive Teff and peripheral autoantigens • Role ... Voir le document complet
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Presentation of neuroendocrine self in the thymus: toward a novel type of vaccine/immunotherapy
... M), the biological meaning of lower affinities may be ...understanding of thymic physiology was gained with the demonstration that a repertoire of neuroendocrine-related, as well as ... Voir le document complet
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Thymus, central T cell self-tolerance and type 1 diabetes
... investigation of neuroendocrine genes expressed in the thymus has led to the identifi- cation of neuroendocrine ...Through the study of insulin-related gene expression in ... Voir le document complet
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The central role of the thymus in the programming of immunological tolerance to neuroendocrine self: Implications for the pathogenesis of autoimmune diseases.
... Role of the thymus in murine ...function of the ...father of Western medicine (129 – 210 AD) Thymos (Θ ψµοσ) = physical association between breath and ... Voir le document complet
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