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[PDF] Top 20 Tertiary Lymphoid Structures and B cells: Clinical impact and therapeutic modulation in cancer

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Tertiary Lymphoid Structures and B cells: Clinical impact and therapeutic modulation in cancer

Tertiary Lymphoid Structures and B cells: Clinical impact and therapeutic modulation in cancer

... as in lung ...immunity and its impact in cancers with low mutational burden is therefore of prominent ...place in the TME where the tumor-associated chronic inflammation promotes the ... Voir le document complet

32

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

... scheme and whether a potent immune response can be generated both locally and ...systemically. In this context, tumor-associated tertiary lymphoid structures (TLS) have become a ... Voir le document complet

14

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

... CA, and approved May 16, 2019 (received for review April 10, 2019) Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support ... Voir le document complet

9

B cells and cancer: To B or not to B?

B cells and cancer: To B or not to B?

... localization and functional orientation of T cells, is of paramount importance for controlling tumor growth and spread (Galon et ...PD-1 and PD-L1, that have revolutionized the treatment of ... Voir le document complet

18

Therapeutic glycoprotein production in mammalian cells

Therapeutic glycoprotein production in mammalian cells

... (TALEN) and CRISPR/Cas9 ( Durai et al., 2005; Porteus and Carroll 2005; Cabaniols et ...Sun and Zhao, 2013 ...ZFN and TALEN technologies rely on the ability to customize a DNA-binding domain ... Voir le document complet

14

Modulators and effectors of inositol hexakisphosphate activity in prostate cancer cells : from clinical prognosis to enhanced therapeutics

Modulators and effectors of inositol hexakisphosphate activity in prostate cancer cells : from clinical prognosis to enhanced therapeutics

... The author and co-authors if applicable retain copyright ownership and moral rights in this document. Neither the whole thesis or dissertation, nor substantial extracts from it, may be printed or ... Voir le document complet

316

Involvement of HIV in the distribution of dendritic cells between lymphoid organs and blood

Involvement of HIV in the distribution of dendritic cells between lymphoid organs and blood

... périartériolaires et un peu dans les zones B. Ces différences pourraient être dues à des différences intrinsèques à chaque espèce ou à un état d’activation des rates que nous avons étudié. En effet l’injection de ... Voir le document complet

234

View of Clostridium difficile infection: clinical, epidemiological and therapeutic aspects

View of Clostridium difficile infection: clinical, epidemiological and therapeutic aspects

... court et la sélection d ’entérocoques résistants à la vancomy- cine est moins fréquente par rapport au bras vancomycine (31 vs 7 %). D ’autres molécules (ramoplanine, rifaximine, nitazoxa- nide) présentent une ... Voir le document complet

11

Detecting and molecular profiling cancer cells in patients

Detecting and molecular profiling cancer cells in patients

... Twelve different ovarian cancer (OvCA) cell lines, and six benign cell lines (two mesothelial cell lines (LP9, LP3); two benign ovarian cell lines (TIOSE4,TIOSE6); primary [r] ... Voir le document complet

173

MicroRNAs, Major Players in B Cells Homeostasis and Function

MicroRNAs, Major Players in B Cells Homeostasis and Function

... B cells start to express IgD and ter- minate their differentiation into follicular (FO) or MZ B cells ( 11 , 68 ...FO B cells are currently associated with a T dependent- ... Voir le document complet

10

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID -repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID -repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages

... concentration and purity of the RNA were esti- mated by optical density ...Biosystems) and cDNA template and forward and reverse primers was ...GCATAG), and VPREB (forward primer: ... Voir le document complet

10

Chimeric antigen receptor T-cells: a new therapeutic option for relapsed/refractory B-cell malignancies and beyond

Chimeric antigen receptor T-cells: a new therapeutic option for relapsed/refractory B-cell malignancies and beyond

... administered in combination with lenalidomide and dexamethasone, refer to the SmPC for these medicinal products for additional ...administered in combination with lenalidomide and ... Voir le document complet

10

X-linked acrogigantism syndrome : Clinical Profile and Therapeutic responses

X-linked acrogigantism syndrome : Clinical Profile and Therapeutic responses

... upregulated in pituitary tumors. We conducted this study to explore the clinical, radiological, and hormonal phenotype and responses to therapy in patients with X-LAG ...X-LAG ... Voir le document complet

15

Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes

Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes

... promising therapeutic approach in the management of GB patients [ 5 , 6 ...accuracy, and a greater biological ...profile, and low doses of radiation are deposited within the entry channel of ... Voir le document complet

17

Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer

Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer

... H3K4me3 and the transcriptional regulator complex ...depicted in green, the Sin3A associated proteins are depicted in blue, and the transcription factors are depicted in ...elevation ... Voir le document complet

15

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

... strategy in the treatment of cancers The molecular mechanisms of the cancer hallmarks mentioned above are/can be targeted by specific drugs interfering with deregulated pH in cancer ... Voir le document complet

75

VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells

VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells

... VIP and PACAP are involved in the development of the nervous ...proliferation and the differentiation of neuronal precursors in vitro and in vivo, and is involved ... Voir le document complet

26

Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.: NK cells in chronic hepatitis C and hepatitis B

Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.: NK cells in chronic hepatitis C and hepatitis B

... reduction in NK cell frequency and a quantitative imbalance between CD56 bright and CD56 dim subsets were observed in chronic HCV patients as compared to HBV patients, underlining that the ... Voir le document complet

13

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

... Dykstra, B., Olthof, S., Schreuder, J., Ritsema, M., and de Haan, ...D., and Klus- mann, ...stem and progenitor cell homeostasis by shifting the balance between TGFbeta and Wnt ... Voir le document complet

16

In vivo monitoring of elastic changes during cancer development and therapeutic treatment

In vivo monitoring of elastic changes during cancer development and therapeutic treatment

... Introduction In Chapter 3, the feasibility of assessing the efficiency of a neo-adjuvant chemotherapy treatment by measuring the tumour volume and global elasticity by conventional Ultrasound (US) ... Voir le document complet

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