[PDF] Top 20 Targeted Therapies in Adult B-Cell Malignancies

... novel targeted drugs such as ibrutinib and idelalisib [ 76 ...Process. In the early twentieth century, War- burg first discovered that cancer cells preferentially consume glucose and metabolize it to ... Voir le document complet

... Abstract Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent ...performed targeted deep sequencing combined with mapping of HTLV-1 proviral integration sites of 61 ... Voir le document complet

... altered in more than 80% of all PDAC patients. In PDAC, preneoplastic lesions (pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasm (MCM) and intra-ductal papillary mucinous neoplasm ... Voir le document complet

... biomarkers. In addition, the functional consequences of hot spot mutations affecting various components of the spliceosome machinery in cancers have been ...pre-mRNA in response to hot spot mutation ... Voir le document complet

... In addition to fibronectin, another ECM structural protein whose production by melanoma cells is affected by inhibitors of the MAPK pathway is type I collagen [ 12 , 92 ...increased in vitro and in ... Voir le document complet

... Lymphoma in 2015(1), despite the availability of modern immunochemotherapy regimens and the introduction of novel agents such as ibrutinib and ...improvements in the therapeutic armamentarium for ... Voir le document complet

... diseases in which CAR T-cells were ...CLL in 2011, results have been reported of CD19-targeted CAR T-cell therapy in a total of 134 CLL ...being in relapse after a large number ... Voir le document complet

... admissions in these patients, various cardiovas- cular toxicities may occur during multiple lines of chemo- therapy and targeted therapies, with progressively higher cumulative ...fied in 1950 ... Voir le document complet

... of adult articular cartilage to regenerate is ...or cell-based therapies using chondro- cytes) may lead to fi brocartilage and not restore hyaline articular cartilage in the long ...implanted ... Voir le document complet

... were adult patients (≥18 years); (ii) had de novo or sec- ondary AML or MDS; (iii) received a reduced-intensity or reduced- toxicity conditioning regimen including fludarabine, ... Voir le document complet

... inflammation- targeted therapy with anti-interleukin (IL)-1β neutralizing antibodies [ 1 ] or colchicine [ 2 , 3 ] for the prevention of recurrent events in patients recovering from an acute coronary syn- ... Voir le document complet

... changes in properties and heterogeneity during ...increase in the use of targeted therapies, including monoclonal antibodies (mAbs), in cancer ...mAbs in advanced clinical ... Voir le document complet

... biomarkers. In addition, the functional consequences of hot spot mutations affecting various components of the spliceosome machinery in cancers have been ...pre-mRNA in response to hot spot mutation ... Voir le document complet

... epitopes. In the last few decades, BsAbs have been developed within the context of cancer therapies and in particular for the treatment of hematologic B-cell ...Advances in ... Voir le document complet

... investigated in CAR-T-cell studies, but yielded varying results ...pursued in an attempt to improve response durability ...antigen in MM, because myeloma cells are mostly CD19-negative by flow ... Voir le document complet

... affected in the course of tumor progression, how the activity of circulating NK cells correlate with relapse or complications, how such an activity might be improved, and how various anticancer agents currently ... Voir le document complet

... Sustained, targeted, high-level transgene expression in primary B lymphocytes may be useful for gene ther- apy in B cell ...candidate B-lineage predominant ... Voir le document complet

... cells in MS patients Figure ...patients in relapse (A) MS patients have a significant higher frequency of T FH cells within their CSF compared to their blood ...1.56% in blood, p ... Voir le document complet

... noticed in a significant proportion of patients and predominant mode of inheritance is autosomal dominant, with some cases with an X-linked transmission 7 ... Voir le document complet

... sharing in rare genetic ...terms in RD-CONNECT) results in a higher diagnostic ...variants in the genes highlighted as part of the treatabolome project will be flagged in RD- ... Voir le document complet