[PDF] Top 20 Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
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Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
... cytometry Cell suspensions from LNs were stained with eBioscience Fixable Viability Dye eFluor 780 (Invitrogen) for 15 min, followed by 10 min blocking in PBS containing 5% normal mouse serum (NMS) and 2% ... Voir le document complet
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
... stem cells (MSCs) are multipotent stromal cells characterized by their ability to differentiate into cells from mesodermal tissue making them an interest- ing cell source for ... Voir le document complet
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T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way
... T cell-deficient mice ( Figures 1 B and 1E) ( Figures S2 ...A–S2D). Stromal and den- dritic cells derived from the MLNs of immuno-competent mice were shown to promote the ... Voir le document complet
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Letters to the Editor: Correspondence re R. Lapointe et al., CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells. Cancer Res 2003;63:2836–43.
... 1. Antigen processing and generation of antigen-specific CD4 ⫹ T ...T cells. Secretion of IFN- ␥ (IFN-)and interleukin 4 (IL-4) by antigen-specific CD4 ⫹ T ... Voir le document complet
3
Regulatory B Cells and Tolerance in Transplantation: From Animal Models to Human
... al. Regulatory B cells and tolerance in transplantation by anti-CD45-RB therapy requires host B cells and that tolerance is mediated through the interaction of ... Voir le document complet
9
P16-29. HIV Nef-specific T cells: Th1/CTL, Th2 and Th17 responses
... USA and 2 INSERM U841, Créteil, France * Corresponding author Background Identification of promiscuous antigenic regions is crucial for the design of an epitope-based ...the responses has been under ... Voir le document complet
2
Integrated Transcriptomic, Phenotypic, and Functional Study Reveals Tissue-Specific Immune Properties of Mesenchymal Stromal Cells
... Mesenchymal stromal cell (MSC) therapy has gained tremendous interest over the past decade, since the seminal proof of concept of its beneficial effect in steroid- resistant graft-versus-host disease ... Voir le document complet
100
Human melanoma-specific CD8 + T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo
... PBMC and metastases from cancer patients have long precluded the analysis of their direct ex vivo cytolytic ...low cell numbers, we aimed at determining the functional competence of melanoma-specific ... Voir le document complet
12
Intestinal epithelial cells instruct myeloid cell-mediated T-cell responses
... patches and mesenteric lymph nodes are sufficient to induce the expression of α4β7- integrin and CCR9 supporting imprinting the gut-homing capacity of activated T- [30] and B- ... Voir le document complet
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B cells with regulatory properties in transplantation tolerance
... blood and since CD22 is also expressed on CD138 + plasma cells, it decreases antibody production [18] ...naive and transitional B cells, to inhibit B cell activation ... Voir le document complet
15
Morphology and expression status investigations of specific surface markers on B-cell chronic lymphocytic leukemia cells
... For the publisher’s version, please access the DOI link below./ Pour consulter la version de l’éditeur, utilisez le lien DOI ci-dessous. https://doi.org/10.1002/jemt.22278 Access and use of this website and ... Voir le document complet
8
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
... °C), and then cultured alone or with 5 ng/ml of recombinant human IL-7 (AbDSerotec) for 3 h at 37 ...ice and the cell pellets resuspended in RLT buffer (Qiagen) containing 1% β mercaptoethanol in ... Voir le document complet
14
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
... Saoudi*, and Roland ...France; and 储 Centre National de la Recherche Scientifique Unite´ Mixte de Recherche 7087, Pitie´-Salpeˆtrie`re Hospital, 75013 Paris, ... Voir le document complet
7
Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization
... adhesion and molecular organization of the plasma membrane of T lymphocytes interacting with a surrogate antigen presenting cell comprising glass supported ordered arrays of antibody (α-CD3) ... Voir le document complet
30
B cells and cancer: To B or not to B?
... localization and functional orientation of T cells, is of paramount importance for controlling tumor growth and spread (Galon et ...PD-1 and PD-L1, that have revolutionized the treatment of ... Voir le document complet
18
Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis
... + regulatory T cells could be a key element of future immunotherapies for several liver diseases allowing restoring the balance between proper immune responses and ...(HBV and HCV), ... Voir le document complet
10
Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 + T cells
... H2-Ab1 H2-DMb1 cytoplasmic stress granule myelin sheath catalytic step 2 spliceosome MHC class II protein complex MHC protein complex regulation of cellular amide metabolic process positive regulation of cytokine ... Voir le document complet
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Continuous Activation of the CD122/STAT-5 Signaling Pathway during Selection of Antigen-Specific Regulatory T Cells in the Murine Thymus.
... ice and their thymus was ...dissociation and trypan blue exclusion counts, 10 6 cells were labeled with 100 m l of a mix of mAbs diluted in PBS containing 3% FCS for 30 minutes at 6–8uC in the ... Voir le document complet
9
Expansion of regulatory T cells in patients with Langerhans cell histiocytosis.
... T cell proliferation in vitro (see Figures 4B and 5C), the presence of IL10 transcripts in the lesion, and the lack of DTH response in vivo in patients with LCH (see Table ...disease and the ... Voir le document complet
12
Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis
... Systemic and locally adminis- tered IL-10 have previously been reported to have clear therapeutic potency in CIA ...dose and timing of the IL-10 treat- ...Col-Treg cells injected at the onset of ... Voir le document complet
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