[PDF] Top 20 Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.
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Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.
... through an important modification of tumor vasculature that appears normalized as described by Carmeliet and Jain (26, ...documented by Mazzone et al. (26) who observed that tumor ... Voir le document complet
32
Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer
... with an increased risk of cancer incidence and progression [ 65 ], this is a highly clinically relevant ...stimulates tumor cell proliferation, invasion, and angiogenesis, inhibits ... Voir le document complet
23
Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion
... reactive tumor stroma is characterized by expansion and activation of the fibroblast population, excessive production of extracellular matrix (ECM), and persistant inflammation ...their increased ... Voir le document complet
20
Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment
... prostate tumor cell invasiveness and immune cell infiltration by altering the levels of anti-angiogenic factors, ECM remodeling factors as well as chemokines, in addition to conserving chemosensitivity in ... Voir le document complet
20
Involvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators.
... transcription by estradiol and the PKC activator cholera toxin/IBMX was dependent on these ...with an estrogen-responsive 2ERE-pS2- CAT reporter, which contains two consensus EREs upstream of the ... Voir le document complet
34
Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.
... Our study also has limitations related to exposure misclassification, confounding, endpoint misclassification, and generalizability of the results. First, we cannot exclude possible misclassification bias arising from ... Voir le document complet
18
Role of plasminogen activator-plasmin system in tumor angiogenesis
... the growth factor domain at the N terminus which binds uPAR and the catalytic domain at the C ...as an inactive single-chain proenzyme (scuPA) which binds to uPAR present on many cell ...cascade by ... Voir le document complet
13
Growth of normalizing sequences in limit theorems for conservative maps
... consider normalizing sequences that can give rise to nondegenerate limit theorems for Birkhoff sums under the iteration of a conservative ...involve normalizing sequences that are polynomial, possibly with ... Voir le document complet
12
CXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis.
... therapeutics ( Foy et al., 2011; Kim and Park, 2005 ). Another example of ef ficient combined treatment is the association of HER-2 and VEGF peptide mimics, which provides greater ef ficacy than individual treat- ments on ... Voir le document complet
9
Cancer-associated adipocytes promotes breast tumor radioresistance.
... mechanism by which the majority of solid tumors respond to clinical RT [3] ...as an energy storage depot, but there is now clear evidences pointing to the fat tissue as an endocrine organ that ... Voir le document complet
6
Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity
... domain by caspases, a preliminary step required for their pro-apoptotic ...cleavage by caspase (Figure 2A, left ...indicated an additional cleavage ...vitro by caspase at Asp 1153 and Asp 1164 ... Voir le document complet
15
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures.
... NMDA receptor activation (Bredt and Snyder 1989; Garthwaite and Boulton 1995), and ii) nNOS subcellular localization within the ...NMDA receptor subunit 2B (NR2B) in the preoptic region of the hypothalamus ... Voir le document complet
30
Molecular Magnetic Resonance and Ultrasound Imaging of Tumor Angiogenesis
... achieved by improving methods for the detection and evaluation of tumors and identifying the expression levels of cell sur- face receptor such as integrins, thus permitting doctors to select the most ... Voir le document complet
10
Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect
... suggested an additive impact of DFMO with Quilamine, we investigated whether PTS activation might potentialize the Quilamine impact in our mouse ...out by combining a blockade of endogenous sources, ... Voir le document complet
35
Normalizing Chemical Reaction Networks by Confluent Structural Simplification
... obtain an unique simplified reaction network, with an unique assignment of the rates, it would be interesting to understand in more detail how they distinguish their unique result from the many others that ... Voir le document complet
17
Estrogen receptor alpha gene variants and major depressive episodes.
... the estrogen-ER complex able to influence the transcription of hundreds of genes (Chen et ...depression by examining major depressive disorder (MDD) across the entire ...in estrogen levels ... Voir le document complet
15
Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis
... Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis2. Lydie Naulé, Clarisse Marie-Luce, Caroline Parmentier, Mariangela Martini, Chris[r] ... Voir le document complet
38
Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents.
... Figure 1 - Interaction of ER α with p53 and Mdm2. (A) GST pull-down assays were carried out as described in material and methods using bacterially expressed GST, GST-Mdm2 or GST-LBD proteins to retain 35 ... Voir le document complet
38
Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.
... reversed by the antiestrogen ICI 182,780 (data not shown) could be observed after transient trans- fection of HELN cells with the ER α ...ER α and ERβ, and at this site ER β is a weaker ... Voir le document complet
12
Influence of adipocyte secretions on proliferation process and tumor angiogenesis
... more increased in the presence of Sn30 (50% ...Similarly, angiogenesis was stimulated in case of obesity since Sn30 increased proliferation (53% vs T, p ... Voir le document complet
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