[PDF] Top 20 Strategies used by bacterial pathogens to cross the blood–brain barrier
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Strategies used by bacterial pathogens to cross the blood–brain barrier
... with brain endothelial cells, bacteria can cross the BBB by different ways: by invading and crossing through brain endothe- lial cells (transcellular pathway), by ... Voir le document complet
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Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.
... or pathogens, lead to TJ disruption following phosphorylation and/or internalization of TJ ...over the last ten years, a number of issues will have to be addressed in the next future, ... Voir le document complet
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An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans
... was used as a marker of the BBB integrity once it does not significantly cross plasma membranes and its paracellular diffusion is hampered by existing tight ...junctions. The ... Voir le document complet
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Integration of an in vitro blood brain barrier model with organic electrochemical transistors
... Introduction The BBB is a specialized endothelial tissue which consists of a very selective barrier formed of brain microvascular endothelial cells which restrict the passage of substances ... Voir le document complet
167
Zika virus crosses an in vitro human blood brain barrier model
... can cross the intact BBB, potentially via a transcellular pathway, and infect susceptible neural cells, notably ...standing the mechanisms of neurotropic virus-mediated BBB and CNS penetration will ... Voir le document complet
10
Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics
... Modelling the BBB In vitro models that can accurately mimic the BBB in culture are crucial tools for the development of brain-permeable drugs at the pre-clinical ...facilitate ... Voir le document complet
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Emerging technologies for delivery of biotherapeutics and gene therapy across the blood–brain barrier
... posed by various anatomical and physiological barriers within the central nervous system (CNS); most notably, the blood–brain barrier ...across the BBB utilizing receptor- ... Voir le document complet
14
Chronic depletion of gonadal testosterone leads to blood–brain barrier dysfunction and inflammation in male mice
... performed by harvesting hypothalamic micro-vessels according to a method adapted from procedure described ...from the pellets with RIPA buffer containing 50 mM Tris – base (pH ... Voir le document complet
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Frequent translation strategies used by Iranian translators in subtitles to translate metaphors
... Collection The first step in this study was to gather the required ...due to certain difficulties finding a reliable source of subtitled films which conform to the norms ... Voir le document complet
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Spatially broad opening of the blood-brain barrier with an unfocused ultrasound transducer in rabbits
... Spatially broad opening of the blood-brain barrier with an unfocused ultrasound transducer in rabbits K. Beccaria a , M. S. Canney b , L. Goldwirt c , C. Fernandez c , C. Adam d , G. Autret e ... Voir le document complet
2
Ultrasound Induced Blood-brain Barrier Opening on Rodents : from Nanoparticles Delivery to a Therapy for Alzheimer’s Disease
... introduced by David E. Kuhl, Luke Chapman and Roy Edwards in the late ...in the body. The system detects pairs of gamma rays emitted indirectly by the radioactive ...tracer. ... Voir le document complet
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Molecular mechanism of ultrasound interaction with a blood brain barrier model
... of the tight junction between two cells. The results are shown in ...separated by intra- distances of ≈ ...of the trajectory with A = 400 bar shown in ...is the membranes and the ... Voir le document complet
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A novel platform for engineering blood-brain barrier-crossing bispecific biologics
... Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous ... Voir le document complet
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
... To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis[r] ... Voir le document complet
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Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens
... similarly to cancer cells reprogramming ( 7 ). This phenotype is explained by a LPS-activated hypoxia- inducible factor 1 α ...shown to increase HIF-1α gene transcription as well as HIF-1α protein ... Voir le document complet
12
Formaldehyde Stress Responses in Bacterial Pathogens
... in the presence generators of oxidative stress such as cumene hydroperoxide and the thiol oxidant diamide ( Kidd et ...tempting to hypothesize that the apparent divergence of function between ... Voir le document complet
17
Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease
... has the following capabilities, which were otherwise difficult to perform with the traditional in vitro BBB transwell models: 1) it provides a 3D microenviron- ment for cells to quantitatively ... Voir le document complet
11
Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound
... reduced the amount of ultrasound energy required to open the BBB by 100-fold ...at the frequency of ultrasound. Above a certain acoustic pressure, the previously symmetrical ... Voir le document complet
31
Interfering with outer membrane biogenesis to fight Gram-negative bacterial pathogens
... separated by the periplasmic space and a thin cell wall. The exter- nal leaflet of the OM is mainly composed of lipopolysac- charide ...Thanks to the highly compacted saturated ... Voir le document complet
6
A dynamic game approach to uninvadable strategies for biotrophic pathogens
... at the expense of a delayed onset of spore ...First, the formalism of [ 23 ] may help to rigorously prove Conjecture ...order to model the transition from one season to another [ ... Voir le document complet
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