[PDF] Top 20 Stability of the cell dynamics in acute myeloid leukemia
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Stability of the cell dynamics in acute myeloid leukemia
... Keywords: Leukemia model, time-delay systems, positive systems, transport equations, Lyapunov method ...Introduction In order to better understand the dynamics of unhealthy ... Voir le document complet
22
Intravenous busulfan for autologous stem cell transplantation in adult patients with acute myeloid leukemia: a survey of 952 patients on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
... is the historical backbone of the busulfan+cyclophosphamide regimen for autologous stem cell ...with acute myeloid leukemia who received intravenous busulfan for ... Voir le document complet
8
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia
... Acute myeloid leukemia affects the transcriptome of human bone marrow NK cells Acute myeloid leukemia (AML) is a speci fic bone marrow disease known to be associated ... Voir le document complet
16
The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party
... frequent in the 8/10 mM-URD group (44 versus <30 %, p = 0.001). The proportions of poor cytogenet- ics were equally distributed between the three groups although cytogenetic analysis ... Voir le document complet
15
ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
... by the ALWP, in accordance with the EBMT guidelines for retrospective ...studies. The EBMT is a voluntary working group of more than 500 transplant depart- ments that are required to ... Voir le document complet
8
The stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
... supported in part by grants from the Kay Kend- all Foundation, the Leukemia Cooperative Group of the EORTC and the National Cancer Institute (grant numbers 5U10 CA11488-22 ... Voir le document complet
8
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... transformed the prognosis of this disease. In the non-promyelocytic leukemia, the discovery of key mutations this last decade led to intense efforts to improve therapeutic ... Voir le document complet
19
Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
... part of a gene set overexpressed in leukemic cells of acute T-cell leukemia/lymphoma patients [13] and to be associated with chemotherapy cross-resistance and treatment outcome ... Voir le document complet
10
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... transduction. The final transduction rate estimated was between 5% and 10% of GFP- positive ...half of the volume of each quadruplicate was pelleted and frozen down to constitute ... Voir le document complet
34
Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... Secondary acute myeloid leukemia (sAML) has been associated with inferior outcomes compared with de novo ...outcomes in sAML after allogeneic hematopoietic stem cell transplantation ... Voir le document complet
9
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
... datasets in function of their IDH1 ...lysates of MOLM14 IDH1 WT and R132H were immunoblotted with the indicated antibodies (representative of two independent ...lysates of ... Voir le document complet
35
Understanding the transcriptional control of EIF4E and its dysregulation in acute myeloid leukemia: role of NF-κB
... Beyond the control of EIF4E, our findings strongly suggest that NF-κB activity is likely heterogeneous amongst AML specimens with regard to other targeted ...promoters. In other words, the ... Voir le document complet
154
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
... that the USP7 level is elevated in several types of tumors, and that USP7 overexpression is often predictive of a poor prognosis [ 9 , 32 , 35 , 36 ...inhibitors of this enzyme have ... Voir le document complet
17
The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs
... overrepresentation of gene ontology categories in biological ...stress in apoptosis and cancer: an ...infected- cell/antibody immune complexes in the enhancement of ... Voir le document complet
10
Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3internal tandem duplication: A position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
... outcomes in 462 allografted FLT3-mutated AML patients over a median follow-up of 39 months for surviving ...median of 55 days after transplantation (range, 1-173) at a median dose of 800 ... Voir le document complet
10
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
... increase in H3K27me2/3 (Figure 20a and 20b). To investigate, the impact of knocking down JMJD3 and UTX in OCI-AML5, we tracked shJMJD3 tdTomato or shUTX GFP marked cells over several passages ... Voir le document complet
89
Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
... and the location of the insertion site within the tyrosine kinase domain [ 39 ...vival in patients receiving chemotherapy alone [ 41 – 43 ], alloHCT has been widely recommended by ... Voir le document complet
12
Impact of conditioning intensity in T-replete haplo-identical stem cell transplantation for acute leukemia: a report from the acute leukemia working party of the EBMT
... with acute myeloid (AML) or lymphoid leukemia (ALL) after RIC (n = 271) and MAC (n = ...combination of post-transplant cyclophosphamide (PT-Cy) with one calcineurin inhibitor and mycophenolate ... Voir le document complet
13
Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia
... when the Cox model was adjusted for in vivo TCD (data not ...improve the safety and efficacy of CBT. Ex vivo expansion of cord blood units [ 47 – 49 ] and co-infusion of ... Voir le document complet
12
en fr Targeting NPM1c in Acute Myeloid leukemia NPM1C, une cible dans le traitement des leucémies aigues myéloides
... apoptosis in NPM1 mutated AMLs only AML cell lines with mutated NPM1 (OCI-AML3, IMS-M2) or WT NPM1 (KG1a, ML-2, THP-1, MOLM-13, HEL) were treated with RA and/or arsenic up to 48 ...for cell cycle ... Voir le document complet
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