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[PDF] Top 20 Gene Silencing Using Chitosan Based siRNA Delivery Systems in Cells and Animals

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Gene Silencing Using Chitosan Based siRNA Delivery Systems in Cells and Animals

Gene Silencing Using Chitosan Based siRNA Delivery Systems in Cells and Animals

... incompatibility and non-specific effects due to large quantities of free excess ...Although gene knockdown (KD) has been achieved, experimental discrepancies, differences in chitosan sources, ... Voir le document complet

329

In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery

In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery

... therapy; siRNA; gene silencing; peptide-based nanoparticles; optical imaging ...involved in cancer progression. siRNAs can enter the RNA-induced silencing complex (RISC), which ... Voir le document complet

12

Large Scale Production, Purification, and Modification of Chitosan-Based Complexes for Gene Therapy

Large Scale Production, Purification, and Modification of Chitosan-Based Complexes for Gene Therapy

... ABSTRACT Chitosan (CS) is a naturally derived cationic polysaccharide which simply self-assembles with nucleic acids (NAs) to form non-soluble polyelectrolyte ...complexes. In recent years, CS-based ... Voir le document complet

147

Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer‐by‐Layer Nanoparticles

Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer‐by‐Layer Nanoparticles

... cancer cells in culture and in animal ...toxicity in animals at the levels tested, and possessed a significant therapeutic ...survival in orthotopic lymphoma mouse ... Voir le document complet

32

Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells

Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells

... delivered siRNA is functional, we investigated if a siRNA sequence targeting the mouse GAPDH transcript delivered into EC via P-selectin lipoplexes (Psel-lipo/siRNA-GAPDH) induces silencing of ... Voir le document complet

19

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

... shown in Figure 5c, these nanoparticles were ineffective in terms of siRNA delivery to epithelial lung tumors, which were generated by the targeted mutation of Kras and p53 genes ... Voir le document complet

25

Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems

Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems

... hydrated and non-reactive form, namely the gem-diol form, is predominant in acidic aqueous ...co-solvent and additional chemical reagents remain necessary to obtain the desired and stable ... Voir le document complet

16

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

... cancer, in particular castration-resistant prostate cancer, for which there is no e fficacious treatment ...deliver siRNA to tumors in xenograft mice for successful gene silencing ... Voir le document complet

12

Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

... further in vitro experiments were led at different concentrations (from 20 to 80 μgmL −1 ) with MA+C and MAF-4+C nanoimpellers (Figure ...cancer cells under TPE (see Figure 5b) at 20 μgmL −1 ... Voir le document complet

16

Cyclodextrins in drug delivery: applications in gene and combination therapy

Cyclodextrins in drug delivery: applications in gene and combination therapy

... ABSTRACT Gene therapy is a powerful tool against genetic disorders and cancer, targeting the source of the disease rather than just treating the ...of gene delivery relied on viral vectors, ... Voir le document complet

34

Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation

Pioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation

... Inducible systems, combined with time point experiments, are a robust way to investigate pioneer activity of a given factor, but are not high-throughput and require expertise to be properly ...inducible ... Voir le document complet

23

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

... ventricle using the trizol ...RNA and PCR was performed on 1/20 of the first ...seconds and terminated by 1 cycle of 1 minute at 95 °C to obtain the dis- sociation ... Voir le document complet

7

Approches de gene silencing pour le traitement de la maladie de Huntington

Approches de gene silencing pour le traitement de la maladie de Huntington

... À ce jour, aucune différence d’efficacité n’a été obser- vée entre les ASO, siARN et les shARN pour le traitement de la maladie de Huntington. Le recul obtenu dans les différents essais cliniques réalisés avec des ... Voir le document complet

9

Organoids in domestic animals: with which stem cells?

Organoids in domestic animals: with which stem cells?

... technology in 2006 truly revolutionized the field of stem cell research [ 51 – 53 ...demonstrated in the mouse model, the concept was extended quickly to non-human primates, humans [ 54 ], and many ... Voir le document complet

10

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

... tighter siRNA-carrier as- sociation improves siRNA potency without increasing up- take also requires further ...altered in our ex- perimental setup, as the endosome-disrupting functional- ity was ... Voir le document complet

14

Designing nanoparticles for highly efficient endothelial siRNA delivery

Designing nanoparticles for highly efficient endothelial siRNA delivery

... While these delivery systems effectively targeted pulmonary endothelial cells in vivo, they required doses much higher than those required for potent hepatocyte silen[r] ... Voir le document complet

136

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

... gels and it was found able to encapsulate anticancer drugs like DOX, thus suggesting a potential use as theranostic ...FF and FFF NSs to emit photoluminescence (PL) in the blue and in ... Voir le document complet

28

Comparative Evaluation of Drone Delivery Systems in Last-Mile Delivery

Comparative Evaluation of Drone Delivery Systems in Last-Mile Delivery

... model and algorithm, we will identify and conduct a sensitivity analysis on several key parameters of the models, including drone speed and flight limit, the number of available drones, number of ... Voir le document complet

59

Cost and resource allocation in healthcare delivery systems

Cost and resource allocation in healthcare delivery systems

... We start by describing the standard single price contract (current practice) and its induced risk due demand uncertainty from both the service requester and the ser[r] ... Voir le document complet

152

Vectors and Gene Delivery to the Retina

Vectors and Gene Delivery to the Retina

... route, gene delivery vectors need to overcome certain obstacles to reach the ...ceptors and gain access to the neurosensory ...vector in close proximity to the ...vectors in the ... Voir le document complet

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