[PDF] Top 20 pH-sensitive micellar systems for controlled drug delivery: synthesis and structural characterization by small-angle neutron scattering

... of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering ...in drug delivery ... Voir le document complet

... The pH in the neighborhood of the tumoral cells is lower than in the healthy ...a pH-sensitive sequence of poly(2-vinylpyridine) ...their drug near the cancerous cells without affecting the ... Voir le document complet

... Results
The aggregation number (and the core radius) do not change when pH varies. The size of the P 2 VP shell does not change either upon pH variation, contrarily to previous work. This could be ... Voir le document complet

... PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks ...alternatives for handling the P2VP ...experimental scattering cross sections leads to important structural ... Voir le document complet

... PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks ...analyzed by SANS and ...alternatives for handling the P2VP ...experimental scattering cross sections ... Voir le document complet

... PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks ...alternatives for handling the P2VP ...experimental scattering cross sections leads to important structural ... Voir le document complet

... Materials and methods ...(DMPC), and octadecylamine, also called stearylamine (SA), were purchased from Sigma (Aldrich, ...prepared by hydration of lipid films as described by Hope et al ... Voir le document complet

... The scattering signal at low wave vectors (q < 2 10 -2 Å -1 ) evolves in terms of shape and intensity with solvent deuteration whereas it remains constant for a given level of deuteration of the ... Voir le document complet

... relevant for a functionally related ...properties, and blocks of oppositely-charged residues are potentially able to form these biomolecular condensates under specific ...regions, and being composed ... Voir le document complet

... values for most SANS ...good for most SANS ...created by diffraction from mirror surface ...background for weak SANS signals, a limiting factor especially at high ...off-specular ... Voir le document complet

... Drug delivery systems have been developed considering various types of materials including mesoporous silica nanoparticles,[1] lipids,[2, 3] and ...magnetic and plasmonic properties, ... Voir le document complet

... inter- and intra-aggregate correlations, both hypotheses seem reasonable, and a detailed modeling of the aggregate structure and interaction would be necessary to solve this ...increases by ... Voir le document complet

... weak neutron flux on the detector area, due to the tiny collimation, the small pixel size and the inherent flux for large wavelengths is the main limita- tion of this kind of ...intensity ... Voir le document complet

... Material and methods 1 Sample preparation The synthesis of poly(styrenesulfonate) is done in several ...deuterated and deuterated versions (for contrast matching SANS ...in-situ by the ... Voir le document complet

... closing, and volumes are ...possible for scattering data analysis because their effects have to be calculated in reciprocal ...missing structural information when only the scattering ... Voir le document complet

... loading and release ...available drug that is incorporated in and only in the porous volume should be as high as possible and the release profile in time should be as progressive as possible, ... Voir le document complet

... in drug pharmaceutical research because they could be used as efficient drug delivery ...micelles by introducing disulfide bridges in the micelle core to provide higher ... Voir le document complet

... observed for small-chains alcohols, also denoted hydrotropes, which exhibit an amphiphilic character but are too small to form ordinary micelles in solution ...the structural complexity of ... Voir le document complet

... in drug pharmaceutical research because they could be used as efficient drug delivery systems 1,2 ...reservoir for the incorporation of lipophilic ...surfaces and in stabilizing ... Voir le document complet

... This fact will likely be very advantageous to the pain management application since the formulation of drug loaded into the delivery device would be exactly the same as what is[r] ... Voir le document complet