[PDF] Top 20 Role of the microtubule-associated protein ATIP3 in cell migration and breast cancer metastasis
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Role of the microtubule-associated protein ATIP3 in cell migration and breast cancer metastasis
... Metastatic cancer cells were injected intracardiacally into the bloodstream of nude mice to reca- pitulate the late, rate-limiting, steps of the metastatic process, and ... Voir le document complet
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Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer
... Abstract Breast cancer is the most common malignancy in women ...over the past decade, this disease remains a public health problem. In the light of precision ... Voir le document complet
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Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
... conditions, the exponentially modified protein abundance index (emPAI) was used as a semi- quantitative ...a protein was considered as differentially expressed when (i) it was detected in one ... Voir le document complet
44
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy
... localization of CD44 in MDA-MB-231 and MDA-MB-231 MSC ...blot and immunofluorescence analyses in- dicated that the interaction of MSCs with cancer cells caused a ... Voir le document complet
7
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
... Indeed the expression of integrin α4/β1 correlates with the development of metastases and is negatively associated with disease-free and overall survival [ 49 ...Moreover, ... Voir le document complet
26
Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice
... characterized the cellular composition of primary tumours in order to understand how chronic CRD can affect the dissemination and metastatic potential of mammary cancer ... Voir le document complet
32
Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3
... Given the potent tumor suppressor effects of ATIP3, these findings may have clinical relevance in the field of ...reported in hepatocellular carcinoma [27], breast ... Voir le document complet
15
en fr ATIP3 deficiency facilitates intracellular accumulation of paclitaxel to reduce cancer cell migration and lymph node metastasis in breast cancer patients Une déficience en ATIP3 facilite l'accumulation intracellulaire de Paclitaxel pour diminuer la migration cellulaire et éradiquer les métastases lymphatiques du cancer du sein
... used in neoadjuvant treatment of breast cancer patients to reduce tumor growth and lymph node ...chemotherapy and predictive biomarkers of chemoresistance are needed. ... Voir le document complet
10
TGFBI modulates tumour hypoxia and promotes breast cancer metastasis
... doi:10.1002/1878-0261.12828 Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular ... Voir le document complet
13
Antioxydation And Cell Migration Genes Are Identified as Potential Therapeutic Targets in Basal-Like and BRCA1 Mutated Breast Cancer Cell Lines
... overexpressed in BLBC. Recently, a phase II clinical trial showed good results (57% of pathological complete response) of panitumumab combined with an anthracycline/taxane-based chemotherapy ... Voir le document complet
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en fr Role of the Thrombospondin 1 in Tumor Migration, Invasion and Metastatic Dissemination in Prostate Cancer and Breast Cancer Rôle de la thrombospondine-1 dans la migration, l’invasion et la dissémination métastatique dans les carcinomes prostatiques et mammaires
... advances in treatment, metastasis remains the most common cause of death from ...extension of survival. Based on the assumption that tumor cells continuously need oxygen ... Voir le document complet
139
The discriminant role of mechanics during cell migration
... Introduction Cell migration is a key phenomenon taking place during many biological events such as embryogenesis, bone remodelling, immune response or ...several cell phenotypes going from ... Voir le document complet
6
Non-Microtubular Localizations of Microtubule-Associated Protein 6 (MAP6)
... MAP6d1-GFP and MAP6d1-myc were ...SDS-PAGE and immunoblotted with each antibody. In the control experiments, COS-7 cells over-expressing either MAP6d1-myc or MAP6d1-GFP were lysed, and ... Voir le document complet
25
Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor
... Populations of industrialized and third world countries are commonly exposed to numerous organic contaminants or ...Several of them are persistent in the environment and ... Voir le document complet
17
Interactome-Transcriptome integration for predicting distant metastasis in breast cancer
... 2006). The Mammaprint 70-gene signature (van de Vijver et ...patients in either good or poor-prognosis ...patients, and 16 for ER-). These two signatures have an overlap of only 3 genes, which ... Voir le document complet
9
Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II.
... co-localization of STOP and tubulin staining in neurites (Figure 5A, upper left panels) whereas phosphorylated STOP staining using P2 antibody showed a diffuse staining, not co-localizing with ... Voir le document complet
20
Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling
... Arl13b-silenced and control MDA-MB-231 cells were immunostained for Vinculin to detect ...to and regulates focal adhesion size and integrin-mediated signaling in breast cancer ... Voir le document complet
18
The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling
... system the human SKBr3 breast cancer cell line, which as it was derived from a HER2-positive tumour, expresses high levels of HER2 (Fig ...6A). In these cells, HER2 is mainly ... Voir le document complet
18
Dual function of ERR alpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.
... together, the significant correlation between high ERRa and OPG in patients and the regulation of OPG by ERRa in BO2 cells provide a mechanistic basis for the ... Voir le document complet
11
The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network.
... Moreover, the dramatic alterations of the 5- HT markers in all the studied areas of STOP KO mice contrasted with the restricted changes of the dopaminergic ... Voir le document complet
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