[PDF] Top 20 The role of frameshifting and transcriptional dysregulation in spinocerebellar ataxia type-3

... transcriptional impairment could be responsible for the degeneration observed in affected fleurons, and since we have shown that in SCA3 this impairment seems to be independent of RNAPII[r] ... Voir le document complet

... Dennis, J., Wang, Q., Bolla, M.K., Swerdlow, A., Ashworth, A., Orr, N., Schoemaker, M., Ko, Y.D., Brauch, H., Hamann, U., Network, G., Andrulis, I.L., Knight, J.A., Glendon, G., Tchatchou, S., kConFab, I., Australian ... Voir le document complet

... prevents the initiation of replication [61] , or with Geminin, which targets the pre-RC component Cdt1, thus inhibiting DNA replication [62] ( ...B and Supplementary ...evaluated the ... Voir le document complet

... neurons. In adult mouse brains, PML becomes re-expressed in the cortex and ...expressed in the adult human brain, in neurons of the substantia nigra (Woulfe ... Voir le document complet

... LG18 In heterozygous plant species like Vitis, the various mar- ker pairs segregation type greatly differ in their accuracy for estimation of recombination frequency with regard to ... Voir le document complet

... stability and efficient ...to the cellular context and are mediated by sequences within the RNA ...Some of these sequences are present in all mRNAs (Figure 2), others are more ... Voir le document complet

... Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for ef[r] ... Voir le document complet

... arise in the context of social interac- tions or daily life ...problems in this domain. Nevertheless, our study is the first exploring both, social cognition and emotional ... Voir le document complet

... ovarian and prostate cancer cell lines, OvCar-3 and PC-3 cells, respectively, were stably transfected to overexpress ...cells and compared to controls, to identify OPNc ... Voir le document complet

... Key words – Eucalyptus, Wood formation, Xylem, Secondary cell wall, Lignin, MYB transcription factor, Linker histone, Hairy roots, Secondary metabolites, second-generation bioethanol....[r] ... Voir le document complet

... Maxwell and Breslow, 2004; Park et ...étude in vitro montrant que le surnageant de cellules sur- exprimant PCSK9 avait la capacité de diminuer l'expression du LDLR à la surface de cellules témoins (Cameron ... Voir le document complet

... The role of 3  UTR–protein complexes in the subcellular lo- calization of EMF proteins The 128 EMF proteins predicted to belong to at least one 3  ... Voir le document complet

... vacuoles and related myonuclear degeneration, mitochondrial pathology and cytoplasmic protein aggregates within ...LC3 and TDP43, are involved in unfolded protein response, en- doplasmic ... Voir le document complet

... scientific and human environment, and regarding this, I have been very ...lucky. The Lamaze and Johannes teams are a melting pot of people, each of them with its own little hint ... Voir le document complet

... Peón, and Terrazas ...implicated in the later stages of ...capacity and ultimately cytotoxic function) were unable to cause diabetes post monocyte depletion, and it was shown ... Voir le document complet

... adopted the orthorhombic lattice conformation (space group: P2 1 2 1 2 1 ), with two molecules of hQR2-FAD and either compound 8′ (Figure 2B) or compound 10 (Figure 2A) per asymmetric ...unit. ... Voir le document complet

... levels of XPC at the elonga- tion regions ( Figure 1 M, S1 D, and ...that the recruitment of the repair factors was specific to the transactiva- tion process, we analyzed ... Voir le document complet

... stabilizing and inhibitory regions in the KRAS 3′ UTR Since the KRAS 3′ UTR provides numerous binding motifs for many RBPs and miRNAs, we employed a series of ... Voir le document complet

... Detection of H 2 S Production Human recombinant 3-MST was produced in an ...system and purified by GenScript (USA). The catalytic activity of 3-MST was tested in ... Voir le document complet

... components of the neuromuscular ...). The majority of patients (85%) display antibodies against the acetylcholine receptor ...Moreover, in the early-onset form of ... Voir le document complet