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[PDF] Top 20 Resistance to therapy in estrogen receptor positive and human epidermal growth factor 2 positive breast cancers: progress with latest therapeutic strategies.

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Resistance to therapy in estrogen receptor positive and human epidermal growth factor 2 positive breast cancers: progress with latest therapeutic strategies.

Resistance to therapy in estrogen receptor positive and human epidermal growth factor 2 positive breast cancers: progress with latest therapeutic strategies.

... is to evaluate this new strategy in the ...designed in the near future to test this ...Mayer and colleagues are investi- gating the combination of the α-specific PI3K inhibitor BYL719 ... Voir le document complet

21

Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

... histopathological and clinical levels [ 12 ...defined: Estrogen/Progesterone Receptor positive (ER + /PR + ), Human Epidermal growth factor Receptor 2 ... Voir le document complet

23

The human epidermal growth factor receptor 2 (HER2) in the breast cancer : from measurement to targeted treatment

The human epidermal growth factor receptor 2 (HER2) in the breast cancer : from measurement to targeted treatment

... Introduction Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor belonging to the family of epidermal growth ... Voir le document complet

334

Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.

Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.

... found in both breast and lung carcinomas than in benign and normal ...mRNAs in intraepithelial cancer areas of the lung and mammary gland indicates that TCSF mRNA ... Voir le document complet

7

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

... (A) In-cell Western assays were performed on A431 cells for eight known EGFR ...square), and 225 þ H11 (closed ...fluorescence and signal relative to that of untreated cells is plotted versus ... Voir le document complet

7

On positive functions with positive fourier transforms

On positive functions with positive fourier transforms

... −i, and thus four highly degenerate ...compatible with real functions remaining real. To span each subspace, we used a basis made of Hermite–Fourier (or “Laguerre–Fourier”) ...have to be ... Voir le document complet

17

Predictive and prognostic role of peripheral blood eosinophil count in triple negative and hormone receptor negative/HER2 positive breast cancers patients undergoing neoadjuvant treatment.

Predictive and prognostic role of peripheral blood eosinophil count in triple negative and hormone receptor negative/HER2 positive breast cancers patients undergoing neoadjuvant treatment.

... Predictive and prognostic role of peripheral blood eosinophil count in triple negative and hormone receptor negative/HER2 positive breast cancers patients undergoing ... Voir le document complet

1

Positive Pressure Fire Resistance Furnace

Positive Pressure Fire Resistance Furnace

... For a previous furnace operating at positive pressure 3 , a satisfactory burner was developed by merely terminating a I-in. long conically shaped with diameters of 1 1/4 in. at each end [r] ... Voir le document complet

8

Reducing Evolutionary Stability to Pure Strategies in Positive Semidefinite Games

Reducing Evolutionary Stability to Pure Strategies in Positive Semidefinite Games

... ESS’s/NSS’s in a game mixed or pure? By answering the second question for special classes of games, we will pave the way to answer the first ...pure strategies. For a smaller class of games, we ... Voir le document complet

7

A phase Ib dose allocation study of oral administration of lucitanib given in combination with fulvestrant in patients with estrogen receptor-positive and FGFR1-amplified or non-amplified metastatic breast cancer

A phase Ib dose allocation study of oral administration of lucitanib given in combination with fulvestrant in patients with estrogen receptor-positive and FGFR1-amplified or non-amplified metastatic breast cancer

... patients with ER+, mBC were enrolled; median age was 66 years, 50% had a PS: 0 and all had received previous endocrine ...(15 in part 1 and 3 in part 2) based on preclinical ... Voir le document complet

11

O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells.

O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells.

... cancer growth and invasion. A number of transcription factors involved in the control of cell proliferation or cell death can be regulated by O- GlcNAc ...detected in cells derived from ... Voir le document complet

18

Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma.

Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma.

... prognostic factor of breast cancer relapse and as a putative predictor of the response to ...NAT1 in the response to endocrine therapy of breast cancer must now be ... Voir le document complet

13

Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

... incubated in 6-well culture plates. Cancer cells were treated with anti-EGFR neutralizing antibody LA1 (Millipore-Upstate), tyrosine kinase inhibitors AG1478 or PD 153035 (Merck-Calbiochem), EGF (R&D ... Voir le document complet

12

Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.

Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.

... Cancer and Nutrition (EPIC) is a multi-center prospective cohort study designed to investigate the relationships between diet, nutrition and metabolic factors and cancer, consis- ting of ... Voir le document complet

13

Anti-CD3/anti-epidermal growth factor receptor-bispecific antibody retargeting of lymphocytes against human neoplastic keratinocytes in an autologous organotypic culture model

Anti-CD3/anti-epidermal growth factor receptor-bispecific antibody retargeting of lymphocytes against human neoplastic keratinocytes in an autologous organotypic culture model

... bimAb to lyse autologous HPV ⫹ keratinocytes growing in mono- layer or in organotypic culture was tested using periph- eral blood lymphocytes of patients from which the HPV ⫹ cell lines KT1 ... Voir le document complet

10

Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor

Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor

... heterodimers in primary cultured VSMCs and the activation of early signaling events by PDGF in these cells occurs through the transactivation of the EGFR via a process that is independent of PDGFR ... Voir le document complet

138

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en fr caracterization of human skin cancer stem cells: implication of Epidermal Growth Factor Receptor signaling pathway in differentiation control of epidermal stem cells Caractérisation des cellules souches cancéreuses de la peau humaine : Implication de la voie de signalisation de l'Epidermal Growth Factor Receptor dans le contrôle de la différenciation des cellules souches de l'épiderme

... La niche est un environnement réduit en oxygène. Cette réduction des ROS permet la protection des cellules souches hématopoïétiques à long terme contre le stress oxydatif (Jang YY et Sharkis SJ, Blood, 2007) et stimule ... Voir le document complet

137

RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor.

RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor.

... [41] and PR is a well-known ERa target gene with a major physiological role in cell ...mRNA and protein expression were significantly decreased as a consequence of RhoB and related ERa ... Voir le document complet

14

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

... presentation and molecular characteristics (reviewed in (1, ...infiltration, and a propensity for hypoxia and necrosis that engenders robust angiogenesis and a perennial ... Voir le document complet

19

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.

... FOXA1 and AR-related genes (UGT2B28A, ALCAM, AGR2, SPDEF and TTF3) expression using spe- cific primers and probes or Gene Expression Assays (Applied Biosystems ...control and final results ... Voir le document complet

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